PMS2 Gene Colorectal Cancer Hereditary Nonpolyposis Type 4 NGS Genetic DNA Test
Comprehensive Genetic Testing for Lynch Syndrome Risk Assessment
The PMS2 Gene Colorectal Cancer Hereditary Nonpolyposis Type 4 NGS Genetic DNA Test represents a breakthrough in personalized cancer risk assessment. This advanced genetic screening specifically targets the PMS2 gene, one of the key DNA mismatch repair genes associated with Lynch syndrome – the most common form of hereditary colorectal cancer. By identifying specific genetic mutations, this test provides individuals and families with critical information to implement proactive cancer prevention strategies and personalized medical management plans.
What Does This Test Measure and Detect?
Our comprehensive NGS (Next-Generation Sequencing) genetic test specifically analyzes the PMS2 gene for:
- Pathogenic mutations associated with Lynch syndrome
- DNA mismatch repair deficiencies
- Specific genetic variants linked to hereditary nonpolyposis colorectal cancer type 4
- Inherited cancer predisposition markers
- Genetic alterations that increase lifetime cancer risk
The test utilizes state-of-the-art NGS technology to provide 99% accuracy in detecting PMS2 gene mutations, offering reliable results for clinical decision-making and family risk assessment.
Who Should Consider This Genetic Test?
This test is particularly recommended for individuals who meet any of the following criteria:
- Personal history of colorectal cancer diagnosed before age 50
- Family history of Lynch syndrome-associated cancers (colorectal, endometrial, ovarian, gastric, urinary tract)
- Multiple primary cancers in the same individual
- Colorectal cancer with abnormal mismatch repair protein expression
- Family members of individuals with known PMS2 gene mutations
- Unexplained family clusters of gastrointestinal cancers
- Individuals with a strong family history of early-onset cancers
Key Benefits of PMS2 Genetic Testing
Undergoing PMS2 gene testing provides numerous advantages for cancer prevention and management:
- Early Risk Identification: Detect genetic predisposition before cancer develops
- Personalized Screening: Tailor cancer surveillance protocols based on genetic risk
- Family Planning Guidance: Make informed decisions about family cancer risk
- Proactive Prevention: Implement targeted prevention strategies
- Treatment Optimization: Guide appropriate cancer treatment options
- Peace of Mind: Reduce uncertainty about inherited cancer risk
Understanding Your Test Results
Your PMS2 gene test results will fall into one of several categories, each with specific implications:
- Positive Result: Indicates the presence of a pathogenic PMS2 mutation, confirming Lynch syndrome diagnosis and requiring enhanced cancer surveillance
- Negative Result: No PMS2 mutation detected, though other genetic factors may still contribute to cancer risk
- Variant of Uncertain Significance: Identifies a genetic change with unknown clinical significance requiring ongoing monitoring
- Benign Variant: Common genetic variation not associated with increased cancer risk
All results are accompanied by comprehensive genetic counseling to ensure proper understanding and appropriate next steps for medical management.
Test Information and Pricing
| Test Component | Details |
|---|---|
| Test Name | PMS2 Gene Colorectal Cancer Hereditary Nonpolyposis Type 4 NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements and Preparation
Before undergoing PMS2 genetic testing, we recommend:
- Complete clinical history documentation of the patient
- Genetic counseling session with our certified genetic counselors
- Development of a detailed pedigree chart documenting family cancer history
- Discussion of testing implications, benefits, and limitations
- Informed consent process for genetic testing
Nationwide Testing Availability
We have testing facilities conveniently located across the United States, serving major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, Charlotte, San Francisco, Indianapolis, Seattle, Denver, Washington DC, Boston, El Paso, Nashville, Detroit, Oklahoma City, Portland, Las Vegas, Memphis, Louisville, Baltimore, and Milwaukee.
Take Control of Your Genetic Health Today
Don’t wait to understand your genetic cancer risk. Our comprehensive PMS2 gene testing provides the critical information needed for proactive cancer prevention and personalized medical management. With our nationwide network of testing centers and expert genetic counseling support, you can make informed decisions about your health and your family’s future.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your PMS2 gene test. Take the first step toward personalized cancer risk management and peace of mind.
