PSEN2 Gene Alzheimer Disease Type 4 NGS Genetic DNA Test
Understanding PSEN2 Gene Alzheimer Disease Type 4
The PSEN2 Gene Alzheimer Disease Type 4 NGS Genetic DNA Test represents a breakthrough in neurological genetic testing, specifically designed to identify mutations in the Presenilin 2 (PSEN2) gene. This gene plays a crucial role in the production of gamma-secretase, an enzyme essential for processing amyloid precursor protein. When mutations occur in the PSEN2 gene, they can lead to abnormal amyloid protein accumulation in the brain, significantly increasing the risk of developing early-onset Alzheimer’s disease, typically between ages 40-65.
What This Advanced Genetic Test Detects
Our comprehensive NGS-based test specifically analyzes:
- Complete sequencing of the PSEN2 gene for pathogenic variants
- Missense mutations associated with autosomal dominant Alzheimer’s disease
- Genetic markers linked to early-onset familial Alzheimer’s disease type 4
- Specific nucleotide changes affecting amyloid-beta protein processing
- Inheritance patterns of Alzheimer’s disease risk factors
Advanced NGS Technology for Precision Results
Utilizing Next-Generation Sequencing (NGS) technology, our test provides unparalleled accuracy in detecting even the most subtle genetic variations. This advanced methodology ensures comprehensive coverage of the PSEN2 gene, offering reliable results that can inform critical healthcare decisions and family planning considerations.
Who Should Consider PSEN2 Genetic Testing?
This test is particularly recommended for individuals experiencing:
- Family history of early-onset Alzheimer’s disease (before age 65)
- Multiple family members diagnosed with Alzheimer’s across generations
- Unexplained memory loss or cognitive decline in younger adults
- Planning for family and wanting to understand genetic risk factors
- Personal concerns about inherited neurological conditions
- Unexplained neurological symptoms with family history of dementia
Clinical Indications for Testing
Medical professionals typically recommend PSEN2 testing when patients present with symptoms including progressive memory impairment, language difficulties, visuospatial problems, or executive function decline, especially when these symptoms appear earlier than typical age-related cognitive changes.
Significant Benefits of Early Genetic Detection
Undergoing PSEN2 genetic testing provides numerous advantages:
- Early Risk Assessment: Identify genetic predisposition years before symptom onset
- Informed Healthcare Planning: Make proactive decisions about future care and lifestyle
- Family Planning Guidance: Understand inheritance risks for future generations
- Targeted Prevention Strategies: Implement lifestyle modifications and monitoring protocols
- Clinical Trial Eligibility: Potential access to cutting-edge Alzheimer’s research and treatments
- Psychological Preparation: Reduce uncertainty and anxiety about genetic risk
Understanding Your Test Results
Your PSEN2 genetic test results will fall into one of several categories:
Positive Result Interpretation
A positive result indicates the presence of a known pathogenic mutation in the PSEN2 gene. This suggests an increased risk for developing early-onset Alzheimer’s disease. However, it’s important to understand that genetic predisposition doesn’t guarantee disease development, and many environmental and lifestyle factors influence actual risk.
Negative Result Interpretation
A negative result means no known pathogenic mutations were detected in the PSEN2 gene. This significantly reduces the risk of developing PSEN2-related Alzheimer’s disease, though it doesn’t eliminate the possibility of developing other forms of dementia or Alzheimer’s through different genetic or environmental factors.
Variant of Uncertain Significance (VUS)
Sometimes, the test may identify genetic changes whose clinical significance isn’t yet fully understood. In such cases, ongoing research and family studies may help clarify the variant’s impact over time.
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | PSEN2 Gene Alzheimer Disease Type 4 NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements and Genetic Counseling
Before undergoing PSEN2 genetic testing, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session with our certified genetic counselors
- Development of a detailed family pedigree chart
- Discussion of potential psychological and emotional implications
- Understanding of insurance and privacy considerations
Nationwide Accessibility Across the United States
We proudly serve patients across all major metropolitan areas in the United States, with convenient testing locations in:
- New York City and surrounding tri-state area
- Los Angeles and Southern California region
- Chicago and Midwest territories
- Houston, Dallas, and Texas locations
- Phoenix, Arizona and Southwest facilities
- Philadelphia, Boston, Miami, and additional major cities
Take Control of Your Neurological Health Today
Understanding your genetic risk for Alzheimer’s disease can be a powerful step toward proactive healthcare management. Our PSEN2 Gene Alzheimer Disease Type 4 NGS Genetic DNA Test provides the comprehensive genetic information you need to make informed decisions about your neurological health and future planning.
Ready to schedule your genetic risk assessment? Contact our genetic specialists today at +1(267) 388-9828 or book your appointment online. Our team is available to answer your questions, provide detailed information about the testing process, and help you take the next step toward understanding your genetic health profile.
Don’t let uncertainty about your genetic risk for Alzheimer’s disease prevent you from taking control of your health journey. With our advanced NGS technology and expert genetic counseling support, you can gain valuable insights that may significantly impact your future health decisions and quality of life.
