Nx Gen Sequencing Maturity Onset Diabetes of Young MODY Test
Comprehensive Genetic Analysis for Early-Onset Diabetes
The Nx Gen Sequencing Maturity Onset Diabetes of Young (MODY) Test represents a breakthrough in diabetes diagnostics, offering precise genetic identification of MODY subtypes through advanced next-generation sequencing technology. MODY is a monogenic form of diabetes characterized by autosomal dominant inheritance and typically manifests before age 25, affecting approximately 1-2% of all diabetes cases. Unlike type 1 or type 2 diabetes, MODY has distinct genetic origins that significantly impact treatment decisions and long-term management strategies.
What This Test Measures and Detects
Our comprehensive MODY genetic panel analyzes 30 critical genes associated with monogenic diabetes:
- ABCC8, AKT2, APPL1, BLK, CEL, CISD2
- EIF2AK3, FOXP3, GCK, GLIS3, GLUD1
- HADH, HNF1A, HNF1B, HNF4A, IER3IP1
- INS, INSR, KCNJ11, KLF11, MNX1
- NEUROD1, NKX2-2, NKX6-1, PAX4
- PDX1, PTF1A, RFX6, SLC2A2, WFS1, ZFP57
This extensive genetic coverage enables detection of mutations responsible for various MODY subtypes, including HNF1A-MODY (MODY 3), GCK-MODY (MODY 2), HNF4A-MODY (MODY 1), and other rare forms. The test identifies single nucleotide variants, small insertions/deletions, and copy number variations that contribute to pancreatic beta-cell dysfunction and impaired insulin secretion.
Who Should Consider MODY Genetic Testing
This test is particularly recommended for individuals presenting with:
- Diabetes diagnosis before age 25 with atypical features
- Strong family history of diabetes across multiple generations
- Mild fasting hyperglycemia without typical diabetes symptoms
- Absence of pancreatic autoantibodies and islet cell antibodies
- Resistance to standard diabetes treatments
- Presence of extra-pancreatic features (renal cysts, genital abnormalities)
- Non-obese individuals with stable mild hyperglycemia
- Patients responding unusually well to sulfonylureas
Clinical Benefits of MODY Genetic Testing
Accurate MODY diagnosis through genetic testing provides numerous clinical advantages:
- Personalized Treatment Selection: Different MODY subtypes respond differently to medications – GCK-MODY often requires no treatment, while HNF1A-MODY responds exceptionally well to sulfonylureas
- Prevention of Unnecessary Insulin Therapy: Many MODY patients can avoid lifelong insulin injections with proper genetic diagnosis
- Improved Glycemic Control: Targeted therapies based on genetic findings lead to better long-term glucose management
- Family Screening Opportunities: Enables early detection and intervention for at-risk family members
- Accurate Prognostic Information: Different MODY subtypes have varying risks for diabetes complications
- Reproductive Counseling: Provides essential information for family planning decisions
Understanding Your Test Results
Your genetic test report will provide comprehensive information about detected variants:
- Pathogenic Variants: Clearly identified mutations known to cause MODY with established clinical significance
- Likely Pathogenic Variants: Genetic changes strongly suspected to be disease-causing based on current evidence
- Variants of Uncertain Significance: Genetic alterations where clinical impact remains unclear – these may require additional family studies
- Benign/Likely Benign Variants: Genetic changes not associated with disease risk
All positive results should be discussed with a genetic counselor or endocrinologist to understand implications for treatment, surveillance, and family member testing. Negative results in the appropriate clinical context may help exclude MODY and redirect diagnostic efforts toward more common diabetes types.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $764 |
Sample Requirements and Processing
Sample Type: 4 mL (2 mL minimum) whole blood in 1 Lavender Top (EDTA) tube
Shipping Instructions: Ship refrigerated. DO NOT FREEZE
Mandatory Documentation: Duly filled Genomics Clinical Information Requisition Form (Form 20)
Turnaround Time: Sample accepted daily by 9 am; Report delivered in 30 working days
Nationwide Accessibility
We have diagnostic centers conveniently located across the United States, serving major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures accessible genetic testing services for patients nationwide.
Take Control of Your Diabetes Diagnosis
Don’t let uncertainty about your diabetes type compromise your treatment and quality of life. The Nx Gen Sequencing MODY Test provides definitive answers that can transform your diabetes management approach. Our specialized molecular diagnostics team, in collaboration with endocrinologists, ensures accurate interpretation and clinical guidance.
Ready to uncover the genetic basis of your diabetes? Contact our genetic counseling team today to schedule your test and take the first step toward personalized diabetes care.
Book Your Test Now: Call or WhatsApp +1(267) 388-9828
Our dedicated patient coordinators are available to answer your questions, assist with insurance inquiries, and help you begin your journey to precise diabetes diagnosis and optimized treatment.
