WNT10A Gene Odontoonychodermal Dysplasia NGS Genetic DNA Test
Comprehensive Genetic Analysis for Rare Dermatological Conditions
The WNT10A Gene Odontoonychodermal Dysplasia NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for rare inherited disorders affecting multiple body systems. This advanced testing methodology provides crucial insights for individuals and families affected by complex genetic conditions involving skin, teeth, nails, and hair development.
What is WNT10A Gene Odontoonychodermal Dysplasia?
Odontoonychodermal dysplasia is a rare autosomal recessive genetic disorder characterized by distinctive abnormalities in tooth development (odontodysplasia), nail formation (onychodysplasia), and skin manifestations (dermatological dysplasia). The condition results from mutations in the WNT10A gene, which plays a vital role in embryonic development, tissue regeneration, and cellular signaling pathways.
What Does This Test Detect?
Our comprehensive NGS genetic test specifically targets and analyzes the WNT10A gene to identify pathogenic variants responsible for odontoonychodermal dysplasia. The test examines:
- Point mutations and single nucleotide variants in the WNT10A gene
- Small insertions and deletions affecting gene function
- Copy number variations and structural abnormalities
- All coding regions and critical regulatory elements
Using Next-Generation Sequencing technology, we achieve unparalleled accuracy in detecting even the most subtle genetic alterations that conventional testing methods might miss.
Who Should Consider This Genetic Test?
Clinical Indications and Symptoms
This test is recommended for individuals presenting with the following symptoms or clinical features:
- Dental Abnormalities: Hypodontia (missing teeth), microdontia (small teeth), enamel defects, and delayed tooth eruption
- Nail Dystrophy: Thin, brittle, or spoon-shaped nails with longitudinal ridging
- Skin Manifestations: Palmoplantar hyperkeratosis, dry skin, and follicular keratosis
- Hair Abnormalities: Sparse scalp hair, eyebrows, and eyelashes
- Family History: Individuals with affected family members or consanguineous parents
- Unexplained Syndromic Features: Patients with multiple system involvement without clear diagnosis
Key Benefits of WNT10A Genetic Testing
Comprehensive Diagnostic Advantages
- Accurate Diagnosis: Provides definitive genetic confirmation for complex clinical presentations
- Family Planning Guidance: Enables informed reproductive decisions and genetic counseling
- Personalized Management: Guides targeted treatment approaches and specialist referrals
- Early Intervention: Facilitates proactive management of associated complications
- Research Contribution: Advances understanding of rare genetic disorders
Understanding Your Test Results
Interpretation and Clinical Implications
Our comprehensive genetic report provides detailed analysis and interpretation of your WNT10A gene sequencing results:
- Positive Result: Identification of pathogenic variants confirms odontoonychodermal dysplasia diagnosis and enables targeted management strategies
- Negative Result: Absence of known pathogenic variants suggests alternative diagnoses should be considered
- Variant of Uncertain Significance: Novel genetic changes require additional family studies and clinical correlation
- Carrier Status: Identification of single pathogenic variant indicates carrier status with implications for family planning
All results are accompanied by detailed clinical interpretation and recommendations from our board-certified genetic specialists.
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Test Specifications
- Turnaround Time: 3 to 4 Weeks
- Sample Type: Blood, Extracted DNA, or One Drop Blood on FTA Card
- Technology: Next-Generation Sequencing (NGS)
- Specialty: Dermatology and Genetics
Pre-Test Requirements
To ensure optimal testing outcomes, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session with pedigree analysis
- Discussion of testing implications and potential outcomes
- Informed consent process
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified collection centers ensures accessible genetic testing services nationwide.
Take the Next Step Toward Genetic Clarity
Don’t let uncertainty about genetic conditions affect your quality of life. Our WNT10A Gene Odontoonychodermal Dysplasia NGS Genetic DNA Test provides the answers you need for informed healthcare decisions and personalized treatment planning.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic test consultation and take control of your genetic health journey.
Our dedicated team of genetic counselors and medical specialists is ready to guide you through the testing process and help you understand your results with compassion and expertise.
