WNK4 Gene Pseudohypoaldosteronism Type 2B NGS Genetic DNA Test
Comprehensive Genetic Analysis for Hypertension and Electrolyte Disorders
The WNK4 Gene Pseudohypoaldosteronism Type 2B NGS Genetic DNA Test represents a breakthrough in precision medicine for diagnosing and managing complex endocrine and renal disorders. This advanced genetic test specifically targets mutations in the WNK4 (With No Lysine K) gene, which plays a critical role in regulating sodium and potassium balance in the kidneys. Pseudohypoaldosteronism Type 2B, also known as Gordon’s syndrome or familial hyperkalemic hypertension, is a rare inherited condition characterized by treatment-resistant hypertension, hyperkalemia (elevated potassium levels), and metabolic acidosis.
What This Test Measures and Detects
Our state-of-the-art NGS (Next-Generation Sequencing) technology comprehensively analyzes the entire WNK4 gene to identify:
- Point mutations and single nucleotide variants
- Insertions and deletions affecting gene function
- Missense, nonsense, and frameshift mutations
- Regulatory region variations impacting gene expression
- Known pathogenic variants associated with Pseudohypoaldosteronism Type 2B
The test provides complete sequencing coverage of the WNK4 gene, ensuring high sensitivity and specificity for detecting even rare genetic variants that may contribute to this complex disorder.
Who Should Consider This Genetic Test
This specialized genetic testing is recommended for individuals presenting with:
- Early-onset or treatment-resistant hypertension
- Persistent hyperkalemia without renal impairment
- Metabolic acidosis of unknown origin
- Family history of hypertension and electrolyte disorders
- Multiple family members with similar symptoms
- Children or adolescents with unexplained hypertension
- Patients with normal renal function but abnormal electrolyte levels
- Individuals with suspected inherited kidney disorders
Clinical Benefits of WNK4 Genetic Testing
Undergoing the WNK4 Gene Pseudohypoaldosteronism Type 2B NGS Genetic DNA Test offers numerous clinical advantages:
- Accurate Diagnosis: Provides definitive genetic confirmation of Pseudohypoaldosteronism Type 2B
- Personalized Treatment: Enables targeted therapy with thiazide diuretics, which are specifically effective for this condition
- Family Planning: Offers genetic counseling opportunities for family members
- Early Intervention: Facilitates proactive management to prevent long-term complications
- Differential Diagnosis: Helps distinguish from other forms of hypertension and electrolyte disorders
- Reduced Healthcare Costs: Eliminates unnecessary diagnostic procedures and ineffective treatments
Understanding Your Test Results
Our comprehensive genetic report provides clear, actionable information:
- Positive Result: Identifies a pathogenic mutation in the WNK4 gene, confirming Pseudohypoaldosteronism Type 2B diagnosis
- Negative Result: No disease-causing mutations detected, suggesting alternative diagnoses should be considered
- Variant of Uncertain Significance (VUS): Identifies genetic changes with unclear clinical significance, requiring further evaluation
- Carrier Status: Determines if individuals carry mutations that could be passed to offspring
All positive results include detailed interpretation by our board-certified genetic counselors, who provide personalized recommendations for management and family testing.
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| WNK4 Gene Pseudohypoaldosteronism Type 2B NGS Genetic DNA Test – Discount Price | $500 |
| WNK4 Gene Pseudohypoaldosteronism Type 2B NGS Genetic DNA Test – Regular Price | $700 |
Turnaround Time: 3 to 4 Weeks
Sample Type: Blood, Extracted DNA, or One Drop Blood on FTA Card
Nationwide Testing Availability
We have conveniently located branches across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our state-of-the-art facilities ensure consistent, high-quality testing services nationwide.
Pre-Test Requirements
Before scheduling your test, please ensure you have:
- Complete clinical history of the patient
- Scheduled genetic counseling session to create a detailed family pedigree
- Documentation of symptoms and previous diagnostic evaluations
- Insurance information and physician referral if required
Take Control of Your Health Today
Don’t let unexplained hypertension and electrolyte imbalances compromise your quality of life. The WNK4 Gene Pseudohypoaldosteronism Type 2B NGS Genetic DNA Test provides the answers you need for effective treatment and long-term health management. Our expert team is ready to guide you through the testing process and help you understand your results.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic test or speak with our genetic counseling team. Take the first step toward personalized medical care and definitive diagnosis.
