UNC13D Gene Hemophagocytic Lymphohistiocytosis Type 3 NGS Genetic DNA Test
Comprehensive Genetic Testing for Life-Threatening Immune Disorders
The UNC13D Gene Hemophagocytic Lymphohistiocytosis Type 3 NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for rare immune system disorders. Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition where the immune system becomes dangerously overactive, attacking the body’s own tissues and organs. Type 3 HLH specifically results from mutations in the UNC13D gene, which plays a critical role in regulating immune cell function and preventing uncontrolled immune responses.
What This Advanced Genetic Test Detects
Our state-of-the-art NGS (Next-Generation Sequencing) technology comprehensively analyzes the UNC13D gene to identify pathogenic variants that disrupt normal immune system function. The test specifically detects:
- Point mutations, insertions, and deletions in the UNC13D gene
- Genetic variants affecting protein function in immune cell regulation
- Inheritance patterns for familial HLH Type 3
- Carrier status for at-risk family members
- Novel mutations associated with immune dysregulation
Who Should Consider UNC13D Genetic Testing
This genetic test is particularly important for individuals presenting with symptoms suggestive of hemophagocytic lymphohistiocytosis or those with a family history of immune disorders. Consider testing if you or your child experiences:
- Persistent unexplained fevers lasting more than 7 days
- Enlarged spleen (splenomegaly) or liver (hepatomegaly)
- Abnormal blood cell counts including cytopenias
- Neurological symptoms such as seizures or altered mental status
- Skin rashes or other dermatological manifestations
- Family history of HLH or early childhood immune disorders
- Recurrent infections with unusual severity
- Elevated inflammatory markers without clear infection source
Significant Benefits of Early Genetic Diagnosis
Early detection through UNC13D genetic testing provides numerous critical advantages for patients and families:
- Timely Treatment Initiation: Enables prompt start of life-saving therapies including immunosuppression
- Family Planning Guidance: Provides essential information for genetic counseling and reproductive decisions
- Preventive Monitoring: Allows for proactive surveillance of at-risk family members
- Treatment Personalization: Guides targeted therapeutic approaches based on genetic findings
- Improved Prognosis: Early intervention significantly enhances long-term outcomes and survival rates
- Reduced Diagnostic Uncertainty: Provides definitive answers after extensive medical evaluations
Understanding Your Test Results
Our comprehensive genetic counseling service helps you interpret your UNC13D test results with clarity and confidence:
- Positive Result: Indicates presence of pathogenic UNC13D mutations confirming HLH Type 3 diagnosis, requiring immediate specialist consultation
- Negative Result: Suggests absence of detectable UNC13D mutations, though other genetic or acquired forms of HLH may require evaluation
- Variant of Uncertain Significance: Identifies genetic changes with unknown clinical impact, necessitating ongoing research and family studies
- Carrier Status: Reveals individuals with one mutated copy who typically don’t develop disease but can pass the mutation to children
Test Pricing and Service Details
| Service | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
Nationwide Accessibility and Expert Support
We maintain comprehensive testing facilities across the United States, with specialized centers in New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and all major metropolitan areas. Our team includes board-certified geneticists, immunologists, and genetic counselors who provide personalized support throughout your testing journey.
Before testing, we require clinical history documentation and conduct a thorough genetic counseling session to create a detailed family pedigree chart. This comprehensive approach ensures we capture essential familial patterns and provide the most accurate genetic assessment possible.
Take Action for Your Health Today
Don’t let uncertainty about immune system disorders compromise your health or your family’s wellbeing. Early genetic testing for UNC13D mutations can provide life-changing clarity and guide appropriate medical management. Our expert team is ready to support you through every step of the genetic testing process.
Call or WhatsApp us now at +1(267) 388-9828 to schedule your UNC13D genetic test consultation and take the first step toward definitive diagnosis and personalized treatment planning.
With our advanced NGS technology, comprehensive genetic counseling, and nationwide accessibility, we provide the gold standard in genetic testing for hemophagocytic lymphohistiocytosis and related immune disorders. Trust our expertise to deliver accurate, timely results that empower you to make informed healthcare decisions.
