UGT1A1 Gene Gilbert Syndrome NGS Genetic DNA Test
Comprehensive Genetic Analysis for Bilirubin Metabolism Disorders
The UGT1A1 Gene Gilbert Syndrome NGS Genetic DNA Test represents a cutting-edge diagnostic approach to identifying genetic predispositions to Gilbert syndrome, a common hereditary condition affecting bilirubin metabolism. This advanced genetic screening utilizes Next-Generation Sequencing technology to provide unparalleled accuracy in detecting mutations within the UGT1A1 gene, which plays a crucial role in the body’s ability to process bilirubin effectively.
What Does This Test Measure and Detect?
This comprehensive genetic analysis specifically targets the UGT1A1 gene, which encodes the enzyme uridine diphosphate glucuronosyltransferase 1A1. This enzyme is essential for the conjugation of bilirubin, a natural byproduct of red blood cell breakdown. The test detects:
- Common UGT1A1 gene polymorphisms, particularly the UGT1A1*28 variant
- Rare mutations affecting bilirubin conjugation efficiency
- Genetic variations that reduce enzyme activity by 30-70%
- Inherited patterns of bilirubin metabolism impairment
- Specific nucleotide changes in the promoter region of the UGT1A1 gene
Who Should Consider This Genetic Test?
This test is particularly recommended for individuals experiencing:
- Intermittent episodes of unexplained jaundice or yellowing of skin and eyes
- Persistent mild elevation of unconjugated bilirubin levels
- Family history of Gilbert syndrome or similar bilirubin metabolism issues
- Unexplained fatigue following fasting, illness, or dehydration
- Abnormal liver function tests without clear underlying cause
- Planning medication regimens that may be affected by UGT1A1 enzyme activity
- Pre-operative assessment for patients with borderline bilirubin levels
Significant Benefits of Genetic Testing
Undergoing the UGT1A1 Gene Gilbert Syndrome NGS Genetic DNA Test provides numerous advantages:
- Accurate Diagnosis: Eliminates uncertainty by providing definitive genetic confirmation
- Personalized Management: Enables tailored lifestyle and medication recommendations
- Family Planning Insights: Provides information about inheritance patterns for future generations
- Medication Safety: Identifies potential drug metabolism concerns related to UGT1A1 activity
- Peace of Mind: Reduces anxiety by explaining the cause of intermittent symptoms
- Preventive Healthcare: Facilitates proactive management of this benign condition
Understanding Your Test Results
Your genetic test results will provide clear guidance about your UGT1A1 gene status:
- Normal Result: Indicates typical UGT1A1 gene function with normal bilirubin conjugation capacity
- Heterozygous Carrier: Shows one copy of the variant gene, typically resulting in mild bilirubin elevation
- Homozygous Affected: Confirms Gilbert syndrome diagnosis with two variant copies and reduced enzyme activity
- Compound Heterozygous: Identifies different mutations on each gene copy, requiring specialized interpretation
Our genetic counseling team will provide comprehensive explanation of your results and their clinical implications during your post-test consultation.
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
Nationwide Testing Accessibility
We maintain comprehensive testing facilities across the United States, with convenient locations in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, and Philadelphia. Our state-of-the-art laboratories ensure consistent, reliable results regardless of your testing location.
Pre-Test Preparation Requirements
To ensure optimal testing accuracy, we require:
- Complete clinical history documentation
- Genetic counseling session to establish family pedigree
- Discussion of test implications and potential outcomes
- Informed consent for genetic testing procedures
Take Control of Your Genetic Health Today
Understanding your genetic predisposition to Gilbert syndrome can significantly impact your healthcare journey. With our advanced NGS technology and expert genetic analysis, you’ll receive comprehensive insights into your bilirubin metabolism capabilities. Don’t let unexplained symptoms create uncertainty – gain clarity through precise genetic testing.
Ready to schedule your UGT1A1 Gene Gilbert Syndrome NGS Genetic DNA Test? Contact our genetic specialists today at +1(267) 388-9828 or book your appointment online. Our team is prepared to guide you through the testing process and provide the answers you need for informed healthcare decisions.
