TRPC6 Gene Focal Segmental Glomerulosclerosis Type 2 NGS Genetic DNA Test
Comprehensive Genetic Testing for Inherited Kidney Disorders
The TRPC6 Gene Focal Segmental Glomerulosclerosis Type 2 NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for kidney health. This advanced test specifically targets mutations in the TRPC6 (Transient Receptor Potential Cation Channel Subfamily C Member 6) gene, which plays a crucial role in maintaining proper kidney filtration function. Focal segmental glomerulosclerosis (FSGS) is a serious kidney condition characterized by scarring in the glomeruli, the tiny filtering units of the kidneys, and Type 2 specifically relates to genetic forms of this disorder.
What This Test Measures and Detects
Our comprehensive NGS-based genetic test analyzes the complete coding region of the TRPC6 gene to identify:
- Pathogenic mutations associated with FSGS Type 2
- Missense, nonsense, and frameshift variants
- Copy number variations affecting TRPC6 function
- Single nucleotide polymorphisms with clinical significance
- Inheritance patterns for family risk assessment
The TRPC6 gene encodes a calcium-permeable cation channel that regulates calcium signaling in podocytes, specialized cells essential for maintaining the kidney’s filtration barrier. Mutations in this gene disrupt normal calcium homeostasis, leading to podocyte injury and progressive kidney damage.
Who Should Consider This Genetic Test
This test is particularly recommended for individuals experiencing:
- Unexplained proteinuria or nephrotic syndrome
- Family history of kidney disease or FSGS
- Progressive renal impairment without clear cause
- Early-onset kidney disease (before age 30)
- Resistance to standard steroid treatments
- Planning pregnancy with family history of kidney disorders
- Recurrent kidney issues across multiple generations
Clinical Benefits of TRPC6 Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous advantages:
- Early Intervention Opportunities: Identify genetic risk before significant kidney damage occurs
- Personalized Treatment Plans: Tailor medications and therapies based on genetic findings
- Family Risk Assessment: Determine inheritance patterns and relative risks
- Reproductive Planning: Make informed decisions about family planning
- Proactive Monitoring: Implement targeted surveillance for at-risk individuals
- Therapeutic Guidance: Avoid ineffective treatments and focus on evidence-based approaches
Understanding Your Test Results
Our comprehensive genetic report provides clear, actionable information:
- Positive Result: Indicates the presence of a known pathogenic mutation. This confirms genetic susceptibility to FSGS and enables proactive management strategies.
- Negative Result: No known pathogenic mutations detected. However, this doesn’t completely rule out genetic factors, as novel mutations may exist.
- Variant of Uncertain Significance (VUS): Identifies genetic changes with unknown clinical impact. These require careful interpretation and may need family studies.
- Carrier Status: Determines if you carry one copy of a mutation, which may be important for family planning decisions.
All results include detailed explanations and recommendations for next steps, including consultation with nephrology specialists and genetic counselors.
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | TRPC6 Gene Focal Segmental Glomerulosclerosis Type 2 NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements
To ensure optimal testing outcomes, we recommend:
- Complete clinical history documentation
- Genetic counseling session prior to testing
- Development of detailed family pedigree chart
- Discussion of potential implications with healthcare provider
- Informed consent process completion
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified collection centers ensures easy access to this vital genetic testing service.
Take Control of Your Kidney Health Today
Don’t wait to understand your genetic risk for kidney disorders. Our TRPC6 Gene FSGS Type 2 NGS Genetic DNA Test provides the critical information needed for proactive kidney health management. With our current discount pricing at $500 USD (regularly $700 USD), now is the perfect time to take this important step toward comprehensive health awareness.
Ready to schedule your test? Contact us today at +1(267) 388-9828 or book your appointment online. Our genetic specialists are available to answer your questions and guide you through the testing process.
