TNFRSF13B Gene Immunodeficiency Common Variable Type 2 NGS Genetic DNA Test
Understanding TNFRSF13B Gene Immunodeficiency Testing
The TNFRSF13B Gene Immunodeficiency Common Variable Type 2 NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for primary immunodeficiency disorders. This advanced test specifically targets mutations in the TNFRSF13B gene, which encodes the transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) protein. TACI plays a critical role in B-cell maturation and antibody production, making this test essential for diagnosing Common Variable Immunodeficiency Type 2 (CVID2).
What This Test Measures and Detects
Our comprehensive NGS-based genetic analysis examines the entire coding region of the TNFRSF13B gene to identify:
- Point mutations affecting TACI protein function
- Insertion and deletion variants disrupting gene expression
- Single nucleotide polymorphisms associated with CVID2
- Copy number variations impacting immune system regulation
- Novel genetic variants with potential clinical significance
Who Should Consider This Genetic Test?
This specialized genetic test is recommended for individuals presenting with:
- Recurrent bacterial infections requiring frequent antibiotic treatment
- Chronic sinusitis, bronchitis, or pneumonia episodes
- Autoimmune manifestations including cytopenias and arthritis
- Gastrointestinal disorders such as inflammatory bowel disease
- Family history of primary immunodeficiency disorders
- Unexplained hypogammaglobulinemia or antibody deficiency
- Delayed diagnosis despite extensive immunological workup
Clinical Benefits of TNFRSF13B Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous clinical advantages:
- Accurate Diagnosis: Confirms CVID2 with molecular precision
- Personalized Treatment: Guides immunoglobulin replacement therapy decisions
- Family Planning: Enables informed reproductive choices and genetic counseling
- Prognostic Insights: Helps predict disease progression and complications
- Therapeutic Monitoring: Assists in evaluating treatment response and adjusting protocols
Understanding Your Test Results
Our comprehensive genetic report provides detailed interpretation of your TNFRSF13B gene analysis:
- Positive Result: Identifies pathogenic variants confirming CVID2 diagnosis
- Variant of Uncertain Significance: Requires additional family studies and clinical correlation
- Negative Result: Suggests alternative causes for immunodeficiency symptoms
- Carrier Status: Identifies individuals with single gene copy mutations
All results include genetic counseling recommendations and clinical management guidance from our expert immunology team.
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Nationwide Testing Availability
We proudly offer TNFRSF13B genetic testing services across the United States with convenient locations in:
- New York City and surrounding metropolitan areas
- Los Angeles and Southern California regions
- Chicago and Midwest territories
- Houston and Texas medical centers
- Phoenix and Southwest facilities
- All major urban centers and regional medical hubs
Take Control of Your Immune Health Today
Don’t let unexplained immune deficiencies compromise your quality of life. Our TNFRSF13B Gene Immunodeficiency Common Variable Type 2 NGS Genetic DNA Test provides the clarity needed for effective treatment planning and improved health outcomes. Contact our genetic counseling team at +1(267) 388-9828 to schedule your comprehensive genetic evaluation and take the first step toward personalized immune health management.
Book your appointment now and receive professional genetic counseling with your test results interpretation.
