Thiopurine Methyltransferase TPMT *2 *3A *3B *3C Genotyping Test
Understanding TPMT Genotyping: Your Key to Safer Medication
Thiopurine Methyltransferase (TPMT) genotyping represents a groundbreaking advancement in personalized medicine, offering crucial insights into how your body processes specific medications. This genetic test examines variations in the TPMT gene that directly impact your ability to metabolize thiopurine drugs—medications commonly prescribed for autoimmune conditions, inflammatory bowel disease, and certain types of cancer.
What Does the TPMT Genotyping Test Measure?
Our comprehensive TPMT genotyping test specifically analyzes four critical genetic variants:
- TPMT *2 variant: A single nucleotide change affecting enzyme stability
- TPMT *3A variant: The most common mutation in Caucasian populations
- TPMT *3B variant: Affects enzyme catalytic activity
- TPMT *3C variant: Common in Asian and African populations
Using advanced Sanger Sequencing technology, we precisely identify these genetic markers to determine your TPMT enzyme activity level, categorizing patients into normal metabolizers, intermediate metabolizers, or poor metabolizers.
Who Should Consider TPMT Genotyping?
This test is particularly important for individuals who:
- Are about to start thiopurine therapy (azathioprine, 6-mercaptopurine, or thioguanine)
- Have experienced unexpected side effects from thiopurine medications
- Have family members with known TPMT deficiencies
- Are being treated for autoimmune diseases like Crohn’s disease or rheumatoid arthritis
- Require immunosuppressive therapy for organ transplantation
- Are undergoing treatment for acute lymphoblastic leukemia
Clinical Benefits of TPMT Testing
Undergoing TPMT genotyping provides numerous advantages:
- Personalized Dosing: Enables healthcare providers to tailor medication dosages based on your genetic profile
- Risk Reduction: Significantly decreases the likelihood of severe bone marrow toxicity
- Improved Treatment Outcomes: Helps achieve therapeutic goals while minimizing adverse effects
- Cost-Effective Care: Prevents expensive hospitalizations due to medication complications
- Enhanced Safety: Provides peace of mind knowing your treatment is genetically appropriate
Understanding Your TPMT Genotyping Results
Your test results will fall into one of three categories:
Normal Metabolizer
Individuals with normal TPMT activity can typically tolerate standard thiopurine doses. This genetic profile indicates efficient medication metabolism and lower risk of toxicity.
Intermediate Metabolizer
Patients with intermediate enzyme activity may require reduced medication doses and closer monitoring. This genetic status suggests partial enzyme function that could lead to accumulation of active metabolites.
Poor Metabolizer
Individuals classified as poor metabolizers have significantly reduced or absent TPMT activity and are at high risk for severe, potentially life-threatening toxicity. These patients typically require substantially lower doses or alternative medications.
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | Thiopurine Methyltransferase TPMT *2 *3A *3B *3C Genotyping |
| Regular Price | $200 USD |
| Discount Price | $150 USD |
| Turnaround Time | 5-7 days |
| Sample Type | Peripheral Blood |
| Test Components | EDTA Vacutainer (2ml) |
| Testing Method | Sanger Sequencing |
Pre-Test Instructions
Thiopurine Methyltransferase (TPMT – *2, *3A, *3B, *3C) Genotyping requires a Doctor’s prescription. Please note that prescription requirements do not apply for surgery and pregnancy cases or individuals planning to travel abroad.
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified laboratories ensures consistent, high-quality testing standards nationwide.
Take Control of Your Medication Safety Today
Don’t leave your medication response to chance. TPMT genotyping provides scientifically validated information that can significantly improve your treatment experience and safety profile. Our genetic experts are ready to help you understand how your unique genetic makeup affects medication metabolism.
Ready to schedule your TPMT genotyping test? Call our dedicated healthcare team at +1(267) 388-9828 or book your appointment online today. Take the first step toward personalized, safer medication management with comprehensive genetic testing from General Genetics Corporation.
