TGM5 Gene Peeling Skin Syndrome Type 2 NGS Genetic DNA Test
Understanding Peeling Skin Syndrome Type 2
Peeling Skin Syndrome Type 2 is a rare genetic disorder characterized by continuous peeling of the skin’s outermost layer. This condition, also known as acral peeling skin syndrome, primarily affects the hands and feet. The TGM5 gene plays a crucial role in maintaining skin integrity by encoding transglutaminase 5, an enzyme essential for proper skin cell adhesion and structural stability.
What Does the TGM5 Gene Test Measure?
Our advanced NGS Genetic DNA Test specifically analyzes the TGM5 gene to identify mutations responsible for Peeling Skin Syndrome Type 2. The test examines:
- Complete TGM5 gene sequencing using next-generation sequencing technology
- Detection of point mutations, insertions, and deletions
- Identification of pathogenic variants affecting transglutaminase 5 function
- Comprehensive analysis of all coding regions and splice sites
Who Should Consider This Genetic Test?
This test is recommended for individuals experiencing:
- Unexplained skin peeling on hands and feet
- Recurrent blistering without trauma
- Family history of similar skin conditions
- Diagnostic uncertainty regarding skin peeling disorders
- Planning for family with known TGM5 gene mutations
Clinical Symptoms Indicating Testing
- Painless peeling of skin on palms and soles
- Superficial blistering after minor friction
- Seasonal variation in symptoms
- Onset in childhood or early adulthood
- No associated inflammation or itching
Benefits of TGM5 Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous advantages:
- Accurate Diagnosis: Confirms or rules out Peeling Skin Syndrome Type 2
- Personalized Treatment: Guides appropriate dermatological management
- Genetic Counseling: Provides essential information for family planning
- Early Intervention: Enables proactive symptom management
- Peace of Mind: Resolves diagnostic uncertainty
Understanding Your Test Results
Your genetic test results will be carefully interpreted by our expert geneticists and dermatologists:
Positive Result
A positive result indicates the presence of pathogenic mutations in the TGM5 gene, confirming the diagnosis of Peeling Skin Syndrome Type 2. Our genetic counselors will provide comprehensive guidance on:
- Management strategies for skin care
- Lifestyle modifications to minimize symptoms
- Family planning considerations
- Regular dermatological follow-up recommendations
Negative Result
A negative result suggests that TGM5 gene mutations are not responsible for your symptoms. This information helps direct further diagnostic evaluation toward other potential causes of skin peeling.
Variant of Uncertain Significance
In some cases, genetic changes of unknown clinical significance may be identified. Our team will provide ongoing monitoring and may recommend additional family studies for clarification.
Test Pricing and Details
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
| Turnaround Time | 3-4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
Pre-Test Requirements
Before scheduling your test, please ensure:
- Complete clinical history documentation
- Genetic counseling session to create family pedigree chart
- Discussion of testing implications with healthcare provider
- Understanding of potential outcomes and their significance
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network of certified collection centers ensures accessible genetic testing for everyone.
Take Control of Your Genetic Health
Don’t let uncertainty about your skin condition affect your quality of life. Our TGM5 Gene Peeling Skin Syndrome Type 2 NGS Genetic DNA Test provides the clarity you need for proper diagnosis and management. With our discounted pricing and comprehensive genetic analysis, you can make informed decisions about your health and future.
Ready to schedule your test? Call our genetic specialists today at +1(267) 388-9828 or book your appointment online. Take the first step toward understanding your genetic makeup and managing your skin health effectively.
