TAC3 Gene Hypogonadotropic Hypogonadism Type 10 with or without Anosmia NGS Genetic DNA Test
Understanding TAC3 Gene Hypogonadotropic Hypogonadism Type 10
Hypogonadotropic hypogonadism type 10 is a rare genetic endocrine disorder characterized by impaired production or action of gonadotropin-releasing hormone (GnRH), which is essential for normal puberty and reproductive function. The TAC3 gene encodes neurokinin B, a crucial neuropeptide involved in the regulation of GnRH secretion from the hypothalamus. Mutations in this gene disrupt the complex neuroendocrine signaling cascade necessary for proper sexual development and reproductive hormone production.
What This Test Measures and Detects
Our advanced NGS Genetic DNA Test specifically analyzes the TAC3 gene to identify pathogenic variants associated with hypogonadotropic hypogonadism type 10. The test detects:
- Point mutations, insertions, and deletions in the TAC3 gene coding regions
- Variants affecting neurokinin B production and function
- Genetic changes that disrupt GnRH pulse generator activity
- Mutations leading to impaired kisspeptin-neurokinin B-dynorphin neuronal signaling
- Both autosomal recessive inheritance patterns
Who Should Consider This Test
This genetic test is recommended for individuals presenting with:
- Delayed or absent puberty beyond age 14 in females and 15 in males
- Primary amenorrhea in females
- Micropenis or cryptorchidism in males
- Infertility with low gonadotropin levels
- Anosmia or hyposmia (complete or partial loss of smell)
- Family history of delayed puberty or reproductive disorders
- Unexplained hypogonadism with normal pituitary imaging
- Consanguineous family background with reproductive issues
Clinical Benefits of Genetic Testing
Undergoing TAC3 gene testing provides numerous clinical advantages:
- Definitive Diagnosis: Confirms genetic etiology of hypogonadotropic hypogonadism
- Personalized Treatment: Guides appropriate hormone replacement therapy
- Reproductive Planning: Informs fertility treatment options and timing
- Family Risk Assessment: Identifies carrier status and inheritance patterns
- Prognostic Information: Helps predict treatment response and long-term outcomes
- Differential Diagnosis: Distinguishes from other forms of hypogonadism
- Psychological Relief: Provides explanation for developmental concerns
Understanding Your Test Results
Your genetic test results will be carefully interpreted by our expert genetic counselors and endocrinologists:
- Positive Result: Identifies pathogenic TAC3 gene mutation confirming diagnosis of hypogonadotropic hypogonadism type 10
- Negative Result: No mutation detected in TAC3 gene, suggesting alternative causes for symptoms
- Variant of Uncertain Significance: Identifies genetic change with unclear clinical impact requiring further evaluation
- Carrier Status: Identifies individuals with one mutated copy who may pass the condition to offspring
All results include comprehensive genetic counseling to ensure complete understanding and appropriate next steps for management and family planning.
Test Pricing and Details
| Test Feature | Details |
|---|---|
| Test Name | TAC3 Gene Hypogonadotropic Hypogonadism Type 10 with or without Anosmia NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements
Before testing, we require:
- Complete clinical history of the patient
- Genetic counseling session to create detailed family pedigree
- Documentation of symptoms and previous endocrine evaluations
- Informed consent for genetic testing
Nationwide Testing Availability
We have convenient testing locations across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified genetic testing centers ensures accessible, reliable service regardless of your location.
Take Control of Your Reproductive Health
Don’t let uncertainty about your reproductive development or family planning decisions cause unnecessary stress. Our TAC3 Gene Hypogonadotropic Hypogonadism Type 10 NGS Genetic DNA Test provides the clarity and answers you need to make informed healthcare decisions. With our discounted price of $500 USD and comprehensive genetic counseling support, you can gain valuable insights into your genetic health.
Ready to schedule your genetic test? Call or WhatsApp us today at +1(267) 388-9828 to book your appointment or speak with our genetic counseling team. Take the first step toward understanding your reproductive health and planning your future with confidence.
