Synovial Sarcoma SS18 FISH Test
Understanding Synovial Sarcoma and the SS18 Genetic Marker
Synovial sarcoma is a rare but aggressive type of soft tissue cancer that primarily affects young adults, accounting for approximately 5-10% of all soft tissue sarcomas. The Synovial Sarcoma SS18 FISH Test represents a breakthrough in molecular diagnostics, specifically designed to detect the characteristic genetic abnormality that defines this malignancy.
This test plays a crucial role in modern oncology by providing definitive diagnostic confirmation when synovial sarcoma is suspected. Unlike traditional diagnostic methods that rely solely on microscopic examination, the SS18 FISH test offers molecular-level precision, enabling healthcare providers to make more informed treatment decisions and improve patient outcomes.
What the SS18 FISH Test Detects
The Synovial Sarcoma SS18 FISH Test specifically identifies the SS18-SSX gene fusion, which occurs in over 95% of synovial sarcoma cases. This chromosomal translocation involves the fusion of the SS18 gene on chromosome 18 with either the SSX1, SSX2, or SSX4 gene on the X chromosome.
Key Detection Capabilities:
- SS18-SSX1 gene fusion (most common variant)
- SS18-SSX2 gene fusion
- SS18-SSX4 gene fusion
- Presence of characteristic chromosomal translocations
- Confirmation of synovial sarcoma diagnosis
Who Should Consider This Test
This specialized genetic test is recommended for individuals presenting with specific clinical scenarios and symptoms that raise suspicion for synovial sarcoma.
Clinical Indications Include:
- Patients with deep-seated soft tissue masses, particularly in extremities
- Young adults (ages 15-40) with suspicious tumors
- Individuals with masses near joints, especially knees
- Patients with rapidly growing soft tissue tumors
- Those with biopsy results suggesting spindle cell morphology
- Cases where differential diagnosis includes other soft tissue sarcomas
Symptoms That May Warrant Testing:
- Persistent painless swelling or lumps
- Deep tissue masses that feel firm or fixed
- Tumors that gradually increase in size
- Limited range of motion near affected areas
- Neurological symptoms if tumors compress nerves
Benefits of Synovial Sarcoma SS18 Testing
Choosing the SS18 FISH test provides multiple advantages for both patients and healthcare providers in managing this complex malignancy.
Diagnostic Precision:
- 99% accuracy in detecting SS18-SSX gene fusions
- Definitive differentiation from other soft tissue tumors
- Reduced diagnostic uncertainty and misdiagnosis
- Molecular confirmation of synovial sarcoma subtype
Clinical Management Advantages:
- Guides appropriate treatment selection
- Helps determine prognosis and disease course
- Supports eligibility for targeted therapies
- Facilitates accurate staging and monitoring
- Enables personalized treatment approaches
Understanding Your Test Results
Interpreting your Synovial Sarcoma SS18 FISH test results requires professional medical guidance, but understanding the basic outcomes can help you prepare for discussions with your healthcare team.
Possible Results Include:
- Positive for SS18-SSX Fusion: Confirms synovial sarcoma diagnosis, indicating the presence of the characteristic genetic abnormality
- Negative for SS18-SSX Fusion: Suggests alternative diagnoses, though rare synovial sarcoma variants may not be detected
- Inconclusive Results: May require additional testing or sample re-evaluation
Next Steps Based on Results:
- Positive results typically lead to comprehensive treatment planning
- Negative results may prompt consideration of other sarcoma types
- All results should be discussed with your oncology specialist
- Results contribute to multidisciplinary tumor board discussions
Test Information and Pricing
| Test Component | Details |
|---|---|
| Test Name | Synovial Sarcoma SS18 FISH Test |
| Regular Price | $300 USD |
| Discount Price | $226 USD |
| Turnaround Time | 7-8 days |
| Sample Type | Tumor tissue |
| Test Components | Paraffin embedded tissue blocks |
| Testing Method | Fluorescence In Situ Hybridization (FISH) |
Pre-Test Instructions and Requirements
The Synovial Sarcoma SS18 FISH Test requires specific preparation and documentation to ensure accurate results and proper billing.
Essential Requirements:
- Doctor’s prescription is required for this test
- Prescription exceptions apply for surgical cases, pregnancy, and international travel planning
- Properly preserved tumor tissue samples
- Complete patient demographic information
- Relevant clinical history and imaging reports
Nationwide Availability and Booking
GGC DNA provides comprehensive genetic testing services across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose.
Our state-of-the-art laboratories employ cutting-edge FISH technology and maintain the highest standards of accuracy and reliability. Each test is performed by certified genetic technologists and reviewed by board-certified molecular pathologists.
Ready to Schedule Your Test?
Take the first step toward accurate diagnosis and personalized treatment. Our genetic counseling team is available to answer your questions and guide you through the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to book your Synovial Sarcoma SS18 FISH Test.
Early and accurate diagnosis is crucial for optimal outcomes in synovial sarcoma management. Trust GGC DNA for precise genetic testing that empowers you and your healthcare team with the information needed to make informed treatment decisions.
