SERPING1 Gene Hereditary Angioedema NGS Genetic DNA Test
Understanding Hereditary Angioedema and SERPING1 Gene Testing
Hereditary angioedema is a rare genetic disorder characterized by recurrent episodes of severe swelling in various body parts, including the face, extremities, gastrointestinal tract, and airways. The SERPING1 Gene Hereditary Angioedema NGS Genetic DNA Test represents a cutting-edge diagnostic approach that utilizes next-generation sequencing technology to identify mutations in the SERPING1 gene, which encodes the C1 inhibitor protein crucial for regulating inflammatory responses.
This comprehensive genetic test plays a vital role in confirming hereditary angioedema diagnosis, enabling healthcare providers to develop targeted treatment strategies and provide accurate genetic counseling for affected families. Early and accurate diagnosis through this test can significantly improve patient outcomes and quality of life.
What the Test Measures and Detects
The SERPING1 Gene Hereditary Angioedema NGS Genetic DNA Test specifically analyzes the SERPING1 gene located on chromosome 11. This advanced genetic screening detects:
- Point mutations affecting C1 inhibitor function
- Insertion and deletion mutations in the SERPING1 gene
- Missense, nonsense, and frameshift mutations
- Splice site variants affecting protein production
- Large deletions or duplications in the gene region
By identifying these specific genetic alterations, the test provides definitive evidence of hereditary angioedema type I or type II, helping distinguish this condition from other forms of angioedema with different underlying causes.
Who Should Consider This Test
Symptoms and Clinical Indications
This genetic test is recommended for individuals experiencing:
- Recurrent episodes of swelling without hives or itching
- Family history of angioedema or sudden swelling episodes
- Unexplained abdominal pain, nausea, or vomiting episodes
- Swelling of face, lips, tongue, or throat
- Limb swelling without apparent injury or allergy
- Difficulty breathing or airway obstruction episodes
- Swelling triggered by stress, trauma, or medical procedures
At-Risk Populations
- Individuals with first-degree relatives diagnosed with hereditary angioedema
- Patients with recurrent swelling episodes of unknown cause
- Those with abnormal C1 inhibitor levels or function tests
- Family members of confirmed hereditary angioedema patients
- Individuals planning pregnancy with family history of angioedema
Benefits of Taking the SERPING1 Genetic Test
Undergoing the SERPING1 Gene Hereditary Angioedema NGS Genetic DNA Test offers numerous advantages:
- Accurate Diagnosis: Provides definitive confirmation of hereditary angioedema, eliminating diagnostic uncertainty
- Personalized Treatment: Enables targeted therapy selection based on specific genetic mutation
- Family Planning: Offers crucial information for genetic counseling and reproductive decisions
- Early Intervention: Facilitates proactive management before severe episodes occur
- Reduced Healthcare Costs: Prevents unnecessary emergency room visits and inappropriate treatments
- Improved Quality of Life: Helps patients better understand and manage their condition
- Genetic Counseling Support: Provides comprehensive guidance for affected individuals and families
Understanding Your Test Results
Positive Result Interpretation
A positive result indicates the presence of a pathogenic mutation in the SERPING1 gene, confirming hereditary angioedema diagnosis. Our genetic counselors will:
- Explain the specific mutation identified and its clinical significance
- Discuss inheritance patterns and family implications
- Provide guidance on treatment options and management strategies
- Recommend testing for at-risk family members
- Offer resources for ongoing support and specialist referrals
Negative Result Interpretation
A negative result suggests no pathogenic SERPING1 mutations were detected. However, this doesn’t completely rule out hereditary angioedema, as rare mutations or other genetic causes might be present. Further evaluation may be recommended based on clinical presentation.
Variant of Uncertain Significance
If a genetic variant of uncertain significance is identified, our team will provide detailed information about the finding and recommend appropriate follow-up testing or monitoring.
Test Information and Pricing
| Test Component | Details |
|---|---|
| Test Name | SERPING1 Gene Hereditary Angioedema NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood or Extracted DNA or One drop Blood on FTA Card |
| Methodology | Next-Generation Sequencing (NGS) Technology |
| Specialty | General Physician, Genetics |
| Disease Category | Vascular Diseases |
Pre-Test Instructions and Requirements
To ensure accurate testing and comprehensive care, we require:
- Complete clinical history of the patient undergoing SERPING1 gene testing
- Genetic counseling session to create a detailed pedigree chart of affected family members
- Proper sample collection following specific guidelines
- Informed consent for genetic testing and potential implications
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, San Francisco, and many more cities nationwide.
Take Control of Your Health Today
Don’t let uncertainty about recurrent swelling episodes affect your quality of life. The SERPING1 Gene Hereditary Angioedema NGS Genetic DNA Test provides the clarity needed for proper diagnosis and management. Our experienced team of genetic specialists and counselors are ready to support you through every step of the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your test. Take the first step toward understanding your genetic health and receiving the personalized care you deserve.
Our comprehensive approach ensures you receive not only accurate genetic testing but also the education and support needed to make informed decisions about your healthcare journey.
