SCN1B Gene Brugada Syndrome Type 5 NGS Genetic DNA Test
Understanding SCN1B Gene Brugada Syndrome Type 5
Brugada syndrome represents a significant inherited cardiac arrhythmia disorder characterized by distinctive electrocardiographic abnormalities and increased risk of sudden cardiac death. The SCN1B gene mutation specifically causes Brugada syndrome type 5, a rare but potentially fatal condition affecting the heart’s electrical system. This genetic variant disrupts sodium channel function in cardiac cells, leading to abnormal heart rhythms that can trigger life-threatening ventricular arrhythmias.
What This Test Measures and Detects
The SCN1B Gene Brugada Syndrome Type 5 NGS Genetic DNA Test employs cutting-edge Next-Generation Sequencing technology to comprehensively analyze the SCN1B gene for pathogenic mutations. This advanced testing methodology enables:
- Complete sequencing of the SCN1B gene coding regions
- Detection of point mutations, insertions, and deletions
- Identification of novel genetic variants associated with cardiac arrhythmia
- High-resolution analysis of sodium channel gene abnormalities
- Comprehensive variant interpretation by certified genetic specialists
Who Should Consider This Genetic Test
This specialized genetic testing is recommended for individuals presenting with specific clinical indications or family history patterns:
Clinical Symptoms and Risk Factors
- Unexplained syncope or fainting episodes
- Family history of sudden cardiac death or Brugada syndrome
- Abnormal ECG findings showing ST-segment elevation in right precordial leads
- Nocturnal agonal respiration or seizure-like episodes
- Documented ventricular fibrillation or tachycardia without structural heart disease
- First-degree relatives of diagnosed Brugada syndrome patients
High-Risk Populations
- Individuals of Southeast Asian descent with higher prevalence
- Young adults with unexplained cardiac events
- Patients with drug-induced Brugada ECG patterns
- Those with fever-induced arrhythmic symptoms
Comprehensive Benefits of Genetic Testing
Undergoing SCN1B genetic testing provides numerous advantages for patients and their families:
Medical Management Benefits
- Accurate diagnosis enabling targeted treatment strategies
- Informed decisions regarding implantable cardioverter-defibrillator placement
- Personalized medication management avoiding sodium channel blockers
- Lifestyle modifications to reduce arrhythmia triggers
- Enhanced monitoring during febrile illnesses
Family Planning and Genetic Counseling
- Identification of at-risk family members through cascade testing
- Informed reproductive decision-making
- Early intervention for affected children
- Comprehensive genetic counseling support
- Development of family-specific management plans
Understanding Your Test Results
Genetic test interpretation requires professional medical expertise, but general guidance includes:
Positive Result Interpretation
- Confirmation of SCN1B gene mutation associated with Brugada syndrome type 5
- Recommendation for comprehensive cardiac evaluation
- Implementation of preventive measures and treatment protocols
- Family member testing and genetic counseling referrals
- Long-term cardiac monitoring and management planning
Negative Result Considerations
- Exclusion of SCN1B-related Brugada syndrome type 5
- Continued investigation for other genetic or acquired causes
- Assessment of other Brugada syndrome genetic subtypes
- Evaluation of non-genetic cardiac conditions
- Ongoing clinical monitoring as indicated by symptoms
Variant of Uncertain Significance
- Genetic changes with unclear clinical implications
- Recommendation for periodic re-evaluation as research advances
- Clinical correlation with patient symptoms and family history
- Consideration of additional genetic testing modalities
Test Pricing and Service Information
| Service Description | Price (USD) |
|---|---|
| SCN1B Gene Brugada Syndrome Type 5 NGS Genetic DNA Test – Discount Price | $500 |
| SCN1B Gene Brugada Syndrome Type 5 NGS Genetic DNA Test – Regular Price | $700 |
Test Specifications
- Turnaround Time: 3 to 4 Weeks
- Sample Type: Blood, Extracted DNA, or One Drop Blood on FTA Card
- Testing Methodology: Next-Generation Sequencing (NGS) Technology
- Specialty: Cardiology and Genetics
- Disease Category: Cardiovascular Disorders
Pre-Test Requirements
Prior to testing, patients should provide:
- Complete clinical history including cardiac symptoms and events
- Genetic counseling session to create detailed family pedigree
- Documentation of affected family members with cardiac conditions
- Recent ECG and cardiac evaluation results when available
Nationwide Testing Availability
General Genetics Corporation provides comprehensive SCN1B genetic testing services across the United States. Our state-of-the-art laboratories and certified genetic counselors are available in all major metropolitan areas including:
- New York City and surrounding regions
- Los Angeles and Southern California
- Chicago and Midwest territories
- Houston and Texas medical centers
- Phoenix and Southwest facilities
- Philadelphia and Northeast locations
- All other major US cities and regions
Take Action for Your Cardiac Health
Early detection of Brugada syndrome type 5 through SCN1B genetic testing can be life-saving. Don’t wait until symptoms escalate – take proactive steps toward understanding your genetic cardiac risk profile today.
Immediate Next Steps
Contact our genetic specialists to schedule your comprehensive evaluation:
- Phone: +1(267) 388-9828
- WhatsApp: +1(267) 388-9828
- Schedule genetic counseling and testing appointment
- Receive personalized pre-test guidance
- Begin your journey toward cardiac health clarity
Our dedicated team of cardiac genetic specialists is ready to provide the expert care and comprehensive testing you deserve. Call today to book your SCN1B Gene Brugada Syndrome Type 5 NGS Genetic DNA Test and take control of your cardiac health future.
