PROKR2 Gene Hypogonadotropic Hypogonadism Type 3 with or without Anosmia NGS Genetic DNA Test
Understanding PROKR2 Gene Hypogonadotropic Hypogonadism
Hypogonadotropic hypogonadism type 3 is a rare genetic condition characterized by impaired production or action of gonadotropin-releasing hormone (GnRH), which is essential for normal sexual development and reproductive function. The PROKR2 gene plays a crucial role in the migration of GnRH neurons during embryonic development, and mutations in this gene can disrupt this critical process, leading to hormonal deficiencies.
What Does This Test Measure?
Our advanced NGS Genetic DNA Test specifically analyzes the PROKR2 gene for mutations associated with:
- Complete sequencing of the PROKR2 gene coding regions
- Detection of point mutations, insertions, and deletions
- Identification of variants affecting GnRH neuron migration
- Assessment of genetic risk for hypogonadotropic hypogonadism
- Evaluation of anosmia-related genetic markers
Who Should Consider This Test?
This genetic test is recommended for individuals experiencing:
- Delayed or absent puberty beyond age 14 in females and 15 in males
- Infertility issues with unknown causes
- Complete or partial loss of smell (anosmia or hyposmia)
- Family history of hypogonadotropic hypogonadism
- Unexplained hormonal imbalances affecting reproductive health
- Children with suspected congenital hormonal disorders
Clinical Symptoms and Indications
Patients with PROKR2 gene mutations typically present with:
- Absent or delayed secondary sexual characteristics
- Primary amenorrhea in females
- Micropenis or cryptorchidism in males
- Reduced libido and sexual function
- Infertility despite normal anatomy
- Associated anosmia in approximately 60% of cases
Benefits of PROKR2 Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous advantages:
- Accurate Diagnosis: Confirms genetic basis for hormonal disorders
- Personalized Treatment: Enables targeted hormonal therapy
- Family Planning: Provides genetic counseling for future generations
- Early Intervention: Allows for timely management of symptoms
- Peace of Mind: Resolves uncertainty about underlying causes
- Comprehensive Care: Integrates with endocrinology and genetics specialists
Understanding Your Test Results
Our genetic counselors will help you interpret your results:
- Positive Result: Indicates a pathogenic mutation in the PROKR2 gene, confirming the genetic diagnosis of hypogonadotropic hypogonadism type 3
- Negative Result: No mutations detected in the PROKR2 gene, though other genetic or non-genetic causes should be considered
- Variant of Uncertain Significance: Identifies genetic changes whose clinical significance is currently unknown, requiring further evaluation
- Carrier Status: Determines if you carry one copy of a mutated gene, which may be important for family planning
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | PROKR2 Gene Hypogonadotropic Hypogonadism Type 3 with or without Anosmia NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next Generation Sequencing (NGS) Technology |
Pre-Test Requirements
Before scheduling your test, please ensure:
- Complete clinical history documentation
- Genetic counseling session to create family pedigree chart
- Discussion of potential implications with healthcare provider
- Understanding of insurance coverage and out-of-pocket costs
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network of certified genetic counselors and endocrinology specialists ensures you receive comprehensive care regardless of your location.
Take the Next Step Toward Diagnosis
If you or a family member are experiencing symptoms of hypogonadotropic hypogonadism or anosmia, don’t wait to get answers. Our advanced PROKR2 genetic testing provides the clarity needed for proper diagnosis and treatment planning.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your test. Our knowledgeable staff is ready to assist you with insurance verification, appointment scheduling, and answering any questions about the testing process.
Early genetic diagnosis can significantly improve quality of life and treatment outcomes. Take control of your reproductive health with our state-of-the-art PROKR2 genetic testing services.
