POMC Gene Obesity Early-Onset Susceptibility NGS Genetic DNA Test
Understanding POMC Gene Obesity and Genetic Predisposition
The POMC Gene Obesity Early-Onset Susceptibility NGS Genetic DNA Test represents a breakthrough in personalized medicine for individuals concerned about genetic predisposition to severe obesity. This advanced diagnostic tool examines the proopiomelanocortin (POMC) gene, which plays a critical role in regulating appetite, energy balance, and body weight through the production of melanocyte-stimulating hormones and other neuropeptides.
Genetic mutations in the POMC gene can lead to disruptions in the hypothalamic-pituitary-adrenal axis, resulting in early-onset obesity that often begins in infancy or childhood. Understanding your genetic makeup through this test provides valuable insights that can guide preventive strategies and personalized treatment approaches for weight management.
What the Test Measures and Detects
Our comprehensive NGS Genetic DNA Test specifically analyzes:
- Complete sequencing of the POMC gene using Next-Generation Sequencing technology
- Detection of point mutations, insertions, deletions, and copy number variations
- Identification of known pathogenic variants associated with early-onset obesity
- Assessment of genetic variants that may affect melanocortin receptor signaling
- Evaluation of mutations impacting alpha-MSH and beta-endorphin production
The test utilizes state-of-the-art NGS methodology to provide comprehensive coverage of the POMC gene region, ensuring high accuracy and reliability in detecting clinically significant genetic variations.
Who Should Consider This Test
Clinical Indications and Symptoms
This genetic test is particularly recommended for individuals experiencing:
- Early-onset obesity beginning in infancy or childhood
- Family history of severe obesity across multiple generations
- Hyperphagia (excessive hunger) that is difficult to control
- Red pigmentation of hair and fair skin (in some POMC deficiency cases)
- Adrenal insufficiency symptoms alongside obesity
- Unexplained rapid weight gain despite normal caloric intake
- Children with obesity developing before age 5
- Individuals with obesity resistant to conventional weight loss methods
Benefits of Taking the POMC Gene Test
Understanding your genetic predisposition to obesity offers numerous advantages:
- Early Intervention Opportunities: Identify genetic risk factors before severe obesity develops
- Personalized Treatment Plans: Tailor dietary and exercise regimens based on genetic profile
- Family Planning Guidance: Understand inheritance patterns for future family planning
- Targeted Medical Management: Guide appropriate pharmacological interventions when necessary
- Psychological Benefits: Reduce guilt and stigma by understanding biological factors
- Comprehensive Health Assessment: Identify associated endocrine disorders early
Understanding Your Test Results
Interpretation Guidance
Your test results will be carefully interpreted by our genetic specialists:
- Positive Result: Indicates the presence of pathogenic POMC gene mutations associated with early-onset obesity susceptibility. This result provides valuable information for proactive management and family counseling.
- Negative Result: No known pathogenic mutations detected in the POMC gene. However, obesity can result from multiple genetic and environmental factors.
- Variant of Uncertain Significance (VUS): Some genetic changes may have unknown clinical significance. Our genetic counselors will provide guidance on monitoring and follow-up.
All results include comprehensive genetic counseling to help you understand the implications for your health and family members.
Test Information and Pricing
| Test Component | Details |
|---|---|
| Test Name | POMC Gene Obesity Early-Onset Susceptibility NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements and Preparation
Before undergoing testing, we require:
- Complete clinical history of the patient including obesity onset and progression
- Genetic counseling session to create a detailed family pedigree chart
- Documentation of family members affected by early-onset obesity
- Review of associated endocrine and metabolic conditions
Nationwide Availability and Booking
We have diagnostic centers conveniently located across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network ensures accessible genetic testing services regardless of your location.
Take the first step toward understanding your genetic predisposition to obesity. Book your POMC Gene Obesity Early-Onset Susceptibility NGS Genetic DNA Test today by calling our genetic specialists at +1(267) 388-9828 or schedule your appointment online.
Our team of genetic counselors and endocrinology specialists are available to answer your questions and guide you through the testing process. Early detection and understanding of genetic factors can significantly impact long-term health outcomes and quality of life.
