PNH Comprehensive Work Up Flow Cytometry FLAER CD14 CD15 CD24 CD45 CD59 CD64 GlyA
Understanding PNH Comprehensive Diagnostic Testing
Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare, acquired blood disorder that affects the bone marrow and leads to the destruction of red blood cells. Our PNH Comprehensive Work Up represents the gold standard in diagnostic testing for this condition, utilizing advanced flow cytometry technology with FLAER (Fluorescently Labeled Aerolysin) and multiple CD markers to provide unparalleled accuracy in detecting PNH clones.
What This Advanced Test Measures
The PNH Comprehensive Work Up employs sophisticated flow cytometry analysis to detect the absence of specific proteins on blood cell surfaces. The test specifically measures:
- FLAER Binding: Detects deficiency in GPI-anchored proteins using fluorescent aerolysin
- CD59 Expression: Identifies missing complement regulatory proteins on red blood cells
- CD55 Analysis: Measures decay-accelerating factor deficiency
- Multiple Cell Line Assessment: Evaluates granulocytes, monocytes, and red blood cells simultaneously
- Clone Size Quantification: Determines the percentage of PNH-affected cells in circulation
Who Should Consider PNH Testing?
This comprehensive diagnostic test is recommended for individuals experiencing symptoms or clinical findings suggestive of PNH, including:
- Unexplained hemolytic anemia with dark urine, especially in the morning
- Recurrent abdominal pain and difficulty swallowing
- Fatigue, weakness, and shortness of breath
- History of blood clots (thrombosis) in unusual locations
- Bone marrow failure syndromes like aplastic anemia
- Unexplained low blood counts affecting multiple cell lines
- Patients with suspected hemoglobinuria or hemosiderinuria
Clinical Importance and Benefits
Early and accurate diagnosis of PNH is crucial for several reasons:
- Prevention of Life-Threatening Complications: Early detection helps prevent thrombosis, kidney failure, and pulmonary hypertension
- Targeted Treatment Planning: Results guide the use of complement inhibitors and other specific therapies
- Disease Monitoring: Regular testing helps track disease progression and treatment response
- Improved Quality of Life: Proper diagnosis leads to better symptom management and reduced complications
- Reproductive Planning: Important for women of childbearing age due to pregnancy-related risks
Understanding Your Test Results
Your PNH Comprehensive Work Up results will provide detailed information about the presence and size of PNH clones in your blood:
- Negative Result: No PNH clones detected – suggests alternative diagnoses should be considered
- Small PNH Clone: Less than 1% of cells affected – may indicate early disease or subclinical PNH
- Moderate PNH Clone: 1-10% of cells affected – requires regular monitoring and potential treatment
- Large PNH Clone: Greater than 10% of cells affected – indicates significant disease requiring immediate intervention
- Multi-lineage Involvement: Results showing PNH cells in granulocytes, monocytes, and red blood cells indicate more extensive disease
Test Pricing and Availability
| Test Name | Regular Price | Discount Price |
|---|---|---|
| PNH Comprehensive Work Up Flow Cytometry FLAER CD14 CD15 CD24 CD45 CD59 CD64 GlyA | $400 USD | $300 USD |
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our state-of-the-art laboratories ensure consistent, high-quality results regardless of location.
Take Control of Your Health Today
Don’t let unexplained symptoms compromise your quality of life. Our PNH Comprehensive Work Up provides the definitive diagnosis needed to guide appropriate treatment and prevent serious complications. With rapid 1-2 day turnaround time and convenient peripheral blood sampling, getting answers has never been easier.
Ready to schedule your test? Call our dedicated healthcare team at +1(267) 388-9828 or book your appointment online today. Take the first step toward accurate diagnosis and effective management of potential PNH.
