PMS1 Gene Nonpolyposis Hereditary Colon Cancer NGS Genetic DNA Test
Comprehensive Genetic Screening for Hereditary Colon Cancer Risk
The PMS1 Gene Nonpolyposis Hereditary Colon Cancer NGS Genetic DNA Test represents a breakthrough in preventive oncology, offering individuals with family histories of colorectal cancer the opportunity to understand their genetic predisposition. This advanced diagnostic tool utilizes next-generation sequencing technology to analyze the PMS1 gene, a critical component of the DNA mismatch repair system. When mutations occur in this gene, they can lead to Lynch syndrome, significantly elevating the risk of developing colon cancer and other associated malignancies.
What Does the PMS1 Gene Test Measure?
This sophisticated genetic analysis specifically targets the PMS1 gene, which plays a vital role in maintaining genomic stability through DNA mismatch repair. The test comprehensively examines:
- Complete PMS1 gene sequencing to identify pathogenic variants
- Point mutations, insertions, and deletions affecting gene function
- Genetic alterations that disrupt DNA repair mechanisms
- Inherited mutations associated with Lynch syndrome predisposition
- Variants that increase lifetime colon cancer risk up to 80%
Who Should Consider PMS1 Genetic Testing?
This test is particularly recommended for individuals who meet any of the following criteria:
- Personal history of colorectal cancer diagnosed before age 50
- Family members with Lynch syndrome-associated cancers
- Multiple relatives across generations with colorectal or endometrial cancer
- Individuals with a known PMS1 mutation in their family
- Those with unexplained polyposis or early-onset gastrointestinal cancers
- Patients with tumors showing microsatellite instability
- Individuals seeking proactive cancer risk assessment
Clinical Benefits of PMS1 Genetic Testing
Undergoing PMS1 genetic testing provides numerous advantages for comprehensive healthcare management:
- Early Risk Identification: Detect genetic predisposition years before cancer development
- Personalized Screening: Implement targeted colonoscopy schedules based on genetic risk
- Family Planning: Make informed reproductive decisions with genetic counseling
- Preventive Interventions: Initiate appropriate surveillance and preventive measures
- Family Member Screening: Identify at-risk relatives who may benefit from testing
- Treatment Guidance: Inform surgical and therapeutic decisions if cancer develops
- Psychological Relief: Reduce uncertainty through definitive genetic information
Understanding Your Test Results
Our certified genetic counselors provide comprehensive result interpretation:
- Positive Result: Indicates a pathogenic PMS1 mutation, confirming Lynch syndrome diagnosis and necessitating enhanced cancer surveillance protocols
- Negative Result: No mutation detected in the PMS1 gene, though other genetic factors may still contribute to cancer risk
- Variant of Uncertain Significance: Identifies genetic changes with unknown clinical impact, requiring ongoing research and family studies
- Family Implications: Results have significant implications for blood relatives who may share the same genetic risk
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Turnaround Time: 3 to 4 Weeks
Sample Type: Blood, Extracted DNA, or One Drop Blood on FTA Card
Nationwide Accessibility
We maintain comprehensive testing facilities across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, San Francisco, and Charlotte. Our network ensures accessible genetic testing services regardless of your location.
Take Control of Your Genetic Health Today
Don’t leave your cancer risk to chance. The PMS1 Gene Nonpolyposis Hereditary Colon Cancer NGS Genetic DNA Test provides definitive answers about your genetic predisposition, empowering you to make informed healthcare decisions. Our team of board-certified genetic counselors and oncology specialists are ready to guide you through the testing process and help interpret your results within the context of your personal and family medical history.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your PMS1 genetic test. Early detection through genetic screening can save lives – take the first step toward proactive cancer prevention now.
