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PML-RARA t(15;17)(q22;q12) Gene Rearrangement Quantitative PCR Test

Original price was: $300.Current price is: $188.

-37%

The PML-RARA t(15;17) Gene Rearrangement Quantitative PCR Test is a highly sensitive molecular diagnostic tool specifically designed to detect and quantify the characteristic genetic abnormality associated with Acute Promyelocytic Leukemia (APL). This test identifies the fusion of PML and RARA genes resulting from chromosomal translocation, which is the hallmark genetic event in APL. Using advanced Real-Time PCR technology, it provides precise quantification of the fusion transcript levels, enabling accurate diagnosis, treatment monitoring, and minimal residual disease detection. The test is crucial for patients presenting with symptoms of acute leukemia, abnormal blood counts, or bleeding tendencies. At only $188 USD, this comprehensive analysis offers vital information for guiding targeted therapy decisions and improving patient outcomes in leukemia management.

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PML-RARA t(15;17)(q22;q12) Gene Rearrangement Quantitative PCR Test

Understanding the PML-RARA Gene Rearrangement Test

The PML-RARA t(15;17) Gene Rearrangement Quantitative PCR Test represents a cornerstone in modern molecular diagnostics for Acute Promyelocytic Leukemia (APL). This sophisticated test detects the specific chromosomal translocation between chromosomes 15 and 17, which results in the fusion of the PML (Promyelocytic Leukemia) gene on chromosome 15 with the RARA (Retinoic Acid Receptor Alpha) gene on chromosome 17. This genetic abnormality is pathognomonic for APL and serves as both a diagnostic marker and therapeutic target.

What This Test Measures and Detects

This advanced quantitative PCR test specifically identifies and measures:

  • The presence of PML-RARA fusion transcripts resulting from t(15;17) translocation
  • Quantitative levels of fusion gene expression
  • Molecular evidence of Acute Promyelocytic Leukemia
  • Baseline disease burden for treatment monitoring
  • Minimal residual disease during and after therapy
  • Early signs of molecular relapse before clinical manifestation

Who Should Consider This Test?

This test is essential for individuals presenting with:

  • Symptoms of acute leukemia including fatigue, weakness, and fever
  • Unexplained bleeding or bruising tendencies
  • Abnormal complete blood count results
  • Suspected Acute Promyelocytic Leukemia based on clinical presentation
  • Patients undergoing treatment for APL requiring monitoring
  • Individuals with family history of hematological malignancies
  • Patients showing poor response to conventional leukemia treatments

Clinical Indications and Symptoms

Patients experiencing the following symptoms should consider this test:

  • Persistent fatigue and general weakness
  • Frequent infections and fever
  • Easy bruising and prolonged bleeding
  • Petechiae (small red spots under the skin)
  • Bone pain or tenderness
  • Unexplained weight loss
  • Swollen lymph nodes
  • Pale skin due to anemia

Benefits of Taking the PML-RARA Test

Choosing this advanced molecular test provides numerous clinical advantages:

  • Accurate Diagnosis: Confirms APL diagnosis with high specificity and sensitivity
  • Treatment Guidance: Enables targeted therapy with all-trans retinoic acid (ATRA)
  • Monitoring Capability: Tracks treatment response and disease progression
  • Early Relapse Detection: Identifies molecular relapse before clinical symptoms appear
  • Prognostic Information: Provides valuable data for predicting treatment outcomes
  • Therapeutic Decision Support: Guides chemotherapy and transplantation decisions
  • Peace of Mind: Offers clarity and direction in leukemia management

Understanding Your Test Results

Your PML-RARA test results will provide critical information about your leukemia status:

  • Positive Result: Indicates presence of PML-RARA fusion, confirming APL diagnosis
  • Quantitative Levels: Higher levels typically correlate with greater disease burden
  • Treatment Response: Decreasing levels indicate positive response to therapy
  • Molecular Remission: Undetectable levels suggest successful treatment
  • Relapse Warning: Reappearance or increasing levels may indicate disease recurrence
  • Clinical Correlation: Results should always be interpreted by your oncologist in clinical context

Test Pricing and Availability

Price Type Amount (USD)
Discount Price $188
Regular Price $300

Test Specifications

  • Turnaround Time: Sample collection Monday/Wednesday/Friday by 9 AM; Reports available Tuesday/Thursday/Saturday
  • Sample Type: 5 mL (3 mL minimum) whole blood from 2 Lavender Top (EDTA) tubes
  • Shipping Instructions: Ship refrigerated. DO NOT FREEZE
  • Required Documentation: Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory
  • Methodology: Real-Time PCR (Quantitative Polymerase Chain Reaction)
  • Specialty: Oncologist-recommended molecular diagnostics

Nationwide Availability

We have diagnostic branches conveniently located across all major cities in the United States, including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, San Francisco, and many more. Our network ensures accessible, high-quality molecular diagnostic services nationwide.

Take Action for Your Health

Don’t wait to get the answers you need for proper leukemia diagnosis and management. Our PML-RARA Gene Rearrangement Quantitative PCR Test provides the precise molecular information required for effective APL treatment. With our special discounted price of only $188 USD, this advanced diagnostic tool is more accessible than ever.

Book your test today by calling or WhatsApp: +1(267) 388-9828

Our dedicated team of genetic specialists and oncology experts is ready to assist you with comprehensive testing, clear result interpretation, and personalized guidance for your leukemia management journey. Early and accurate diagnosis through molecular testing can significantly impact treatment success and long-term outcomes in Acute Promyelocytic Leukemia.

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