PLCE1 Gene Nephrotic Syndrome Type 3 NGS Genetic DNA Test
Comprehensive Genetic Testing for Inherited Kidney Disorders
The PLCE1 Gene Nephrotic Syndrome Type 3 NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for inherited kidney diseases. This advanced molecular test utilizes next-generation sequencing technology to identify mutations in the PLCE1 gene, which plays a critical role in podocyte function and glomerular filtration barrier integrity. Nephrotic syndrome type 3 is an autosomal recessive disorder characterized by early-onset steroid-resistant nephrotic syndrome, often progressing to end-stage renal disease.
What This Test Measures and Detects
This comprehensive genetic analysis specifically targets the PLCE1 (Phospholipase C Epsilon 1) gene, which encodes an enzyme essential for maintaining the structural integrity of kidney podocytes. The test detects:
- Pathogenic variants and mutations in the PLCE1 gene
- Single nucleotide polymorphisms associated with nephrotic syndrome
- Copy number variations affecting gene function
- Novel genetic variants with potential clinical significance
- Inheritance patterns for family risk assessment
Who Should Consider This Test
This genetic test is recommended for individuals presenting with:
- Early-onset nephrotic syndrome (before age 5)
- Steroid-resistant nephrotic syndrome
- Family history of inherited kidney disorders
- Unexplained proteinuria and hypoalbuminemia
- Progressive renal failure without clear etiology
- Consanguineous parents with kidney disease history
- Children with congenital nephrotic syndrome
Clinical Benefits of Genetic Testing
Undergoing the PLCE1 Gene Nephrotic Syndrome Type 3 NGS Genetic DNA Test provides numerous clinical advantages:
- Accurate Diagnosis: Confirms genetic etiology of nephrotic syndrome
- Personalized Treatment: Guides targeted therapeutic approaches
- Prognostic Information: Helps predict disease progression and outcomes
- Family Planning: Provides essential information for reproductive decisions
- Early Intervention: Enables proactive management strategies
- Genetic Counseling: Supports informed decision-making for families
Understanding Your Test Results
Your genetic test results will be carefully interpreted by our expert geneticists and nephrologists:
- Positive Result: Indicates presence of pathogenic PLCE1 mutations confirming diagnosis of nephrotic syndrome type 3
- Negative Result: Suggests absence of detectable PLCE1 mutations, though other genetic causes may be considered
- Variant of Uncertain Significance: Requires additional clinical correlation and family studies
- Carrier Status: Identifies individuals with single mutation who may pass the condition to offspring
All results include comprehensive genetic counseling to ensure proper understanding and appropriate next steps.
Test Pricing Information
| Test Description | Price (USD) |
|---|---|
| PLCE1 Gene Nephrotic Syndrome Type 3 NGS Genetic DNA Test – Discount Price | $500 |
| PLCE1 Gene Nephrotic Syndrome Type 3 NGS Genetic DNA Test – Regular Price | $700 |
Nationwide Availability and Testing Process
We have diagnostic centers conveniently located across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our testing process includes:
- Sample Collection: Blood draw or extracted DNA sample at any of our facilities
- Turnaround Time: 3-4 weeks for comprehensive analysis and reporting
- Pre-test Requirements: Clinical history documentation and genetic counseling session
- Professional Support: Access to genetic counselors and nephrology specialists
Take Control of Your Kidney Health Today
Don’t let uncertainty about inherited kidney conditions affect your health decisions. The PLCE1 Gene Nephrotic Syndrome Type 3 NGS Genetic DNA Test provides the clarity you need for informed medical management and family planning. Our team of genetic specialists and nephrologists are ready to support you through every step of the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your test. Take the first step toward understanding your genetic risk and protecting your kidney health for the future.
