PDGFR cKIT Gastrointestinal Stromal Tumors Genetic Test
Comprehensive Introduction to GIST Genetic Testing
The PDGFR cKIT Gastrointestinal Stromal Tumors test represents a breakthrough in molecular oncology diagnostics, specifically designed to detect genetic mutations that drive the development of gastrointestinal stromal tumors (GISTs). These rare but significant tumors originate in the gastrointestinal tract and require precise genetic characterization for optimal treatment planning. Understanding the genetic profile of GISTs has revolutionized how oncologists approach treatment, moving from traditional chemotherapy to targeted therapies that specifically address the underlying molecular drivers of tumor growth.
What This Advanced Test Measures and Detects
This sophisticated genetic analysis focuses on identifying mutations in two critical genes:
- KIT Gene Mutations: Detects alterations in exons 9, 11, 13, and 17, which account for approximately 75-80% of all GIST cases
- PDGFRA Gene Mutations: Identifies mutations in exons 12, 14, and 18, responsible for 5-10% of GIST cases
- Wild-type GIST Identification: Helps identify tumors without KIT or PDGFRA mutations, which may require different treatment approaches
Clinical Significance of Detected Mutations
The specific mutation profile detected by this test provides crucial information about tumor behavior, potential response to targeted therapies, and overall prognosis. Different mutation types respond differently to various tyrosine kinase inhibitors, making this genetic information essential for personalized treatment selection.
Who Should Consider This Genetic Test
This test is particularly important for individuals experiencing:
- Unexplained abdominal pain or discomfort
- Gastrointestinal bleeding or anemia
- Palpable abdominal mass
- Unexplained weight loss or fatigue
- Nausea, vomiting, or early satiety
- Patients with newly diagnosed GISTs for treatment planning
- Individuals with family history of GIST or related syndromes
Special Considerations for Testing
The PDGFR cKIT Gastrointestinal Stromal Tumors test requires a doctor’s prescription for most cases. However, prescriptions are not applicable for surgical planning, pregnancy-related cases, or individuals planning international travel. Consultation with an oncologist or gastroenterologist is recommended to determine the appropriateness of testing.
Significant Benefits of Genetic Testing for GIST
- Personalized Treatment Selection: Identifies the most effective targeted therapies based on specific mutation profiles
- Prognostic Information: Provides insights into tumor behavior and potential clinical outcomes
- Therapy Response Prediction: Helps predict how tumors will respond to different tyrosine kinase inhibitors
- Risk Assessment: Aids in determining recurrence risk and guiding surveillance strategies
- Family Screening Guidance: May identify hereditary components in rare familial GIST cases
Understanding Your Test Results
Your genetic test results will provide detailed information about:
- Mutation Status: Clear identification of KIT or PDGFRA mutations, or wild-type status
- Specific Mutation Type: Detailed information about the exact genetic alteration detected
- Clinical Implications: How the detected mutations influence treatment options and prognosis
- Therapeutic Recommendations: Guidance on appropriate targeted therapy selection
Interpreting Negative Results
If no KIT or PDGFRA mutations are detected (wild-type GIST), this information is equally valuable as it directs physicians toward alternative diagnostic considerations and treatment approaches, including potential clinical trial eligibility.
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| Discount Price | $376 |
| Regular Price | $500 |
| Turnaround Time | 7-8 Days |
| Sample Type | Tumor Tissue (Paraffin Embedded Blocks) |
Nationwide Testing Availability
We have established testing facilities across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures that patients nationwide have access to this advanced genetic testing without the need for extensive travel.
Take Action for Your Health Today
Don’t leave your gastrointestinal health to chance. The PDGFR cKIT Gastrointestinal Stromal Tumors test provides critical information that can significantly impact your treatment journey and overall outcomes. Our experienced genetic counselors and oncology specialists are available to discuss your testing options and help you understand how this advanced genetic analysis can benefit your specific situation.
Ready to take the next step? Book your PDGFR cKIT Gastrointestinal Stromal Tumors test today by calling our dedicated healthcare line at +1(267) 388-9828 or schedule your consultation through our online booking system. Our team is standing by to assist you with scheduling, insurance questions, and any concerns you may have about the testing process.
