PCNA Proliferating Cell Nuclear Antigen Antibody Test
Understanding the PCNA Antibody Test
The PCNA Proliferating Cell Nuclear Antigen Antibody Test represents a sophisticated diagnostic approach in autoimmune disease evaluation. This specialized laboratory assessment detects antibodies directed against proliferating cell nuclear antigen (PCNA), a critical protein involved in DNA replication and cellular repair mechanisms. When the immune system mistakenly targets PCNA, it creates specific autoantibodies that serve as important biomarkers for various autoimmune conditions.
What Does the PCNA Test Measure?
This advanced diagnostic test specifically identifies and quantifies antibodies that target the proliferating cell nuclear antigen. PCNA functions as a DNA sliding clamp that plays an essential role in DNA synthesis and repair processes within rapidly dividing cells. The presence of anti-PCNA antibodies indicates an autoimmune response where the body’s immune system incorrectly identifies this vital cellular component as foreign, leading to antibody production that can be measured through sophisticated laboratory techniques.
Who Should Consider This Test?
This specialized diagnostic assessment is particularly valuable for individuals experiencing symptoms suggestive of autoimmune disorders. Consider scheduling this test if you present with:
- Unexplained joint pain and swelling that migrates between joints
- Persistent skin rashes, particularly butterfly-shaped facial rashes
- Chronic fatigue that doesn’t improve with rest
- Recurrent fevers without apparent infection
- Photosensitivity or unusual reactions to sunlight
- Unexplained hair loss or mouth sores
- Chest pain when taking deep breaths
- Kidney problems or abnormal urine tests
- Neurological symptoms including seizures or cognitive changes
Clinical Benefits of PCNA Antibody Testing
Undergoing PCNA antibody testing provides multiple clinical advantages for patients and healthcare providers:
- Early Disease Detection: Identifies autoimmune activity before significant organ damage occurs
- Differential Diagnosis: Helps distinguish between different autoimmune conditions with overlapping symptoms
- Disease Monitoring: Tracks disease progression and treatment response over time
- Personalized Treatment: Guides targeted therapeutic approaches based on specific antibody profiles
- Prognostic Information: Provides insights into potential disease course and complications
Understanding Your Test Results
Interpreting PCNA antibody test results requires professional medical expertise, but general guidance includes:
Positive Results
A positive PCNA antibody test indicates the presence of antibodies targeting proliferating cell nuclear antigen. This finding is strongly associated with systemic lupus erythematosus (SLE), particularly in cases with more severe disease manifestations. Positive results should be interpreted in the context of clinical symptoms and other laboratory findings to establish a comprehensive diagnosis.
Negative Results
A negative test result suggests the absence of detectable PCNA antibodies. However, this does not completely rule out autoimmune conditions, as antibody patterns can vary between individuals and throughout disease progression. Your rheumatologist will consider this result alongside other clinical and laboratory findings.
Quantitative Interpretation
The test provides quantitative measurements that help determine antibody levels. Higher titers often correlate with more active disease states, while fluctuating levels may indicate changing disease activity or treatment response.
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | PCNA Proliferating Cell Nuclear Antigen Antibody Test |
| Regular Price | $700 USD |
| Discount Price | $550 USD |
| Sample Type | 2 mL (1 mL min.) serum from 1 SST |
| Shipping Requirements | Ship refrigerated or frozen |
| Turnaround Time | 2-3 weeks after sample receipt |
| Testing Method | Indirect Immunofluorescence Assay |
| Required Documentation | Duly filled Test Send Out Consent Form (Form 35) |
Nationwide Testing Availability
GGC DNA maintains comprehensive testing facilities across major metropolitan areas throughout the United States. Our strategically located branches ensure convenient access to advanced autoimmune diagnostics in cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Each facility adheres to the highest standards of laboratory excellence and patient care.
Take Control of Your Health Today
Early detection of autoimmune conditions through specialized testing like the PCNA antibody assessment can significantly impact treatment outcomes and quality of life. Don’t wait for symptoms to progress – take proactive steps toward understanding your health status. Our experienced team is ready to assist you with scheduling, sample collection, and result interpretation.
Call us today at +1(267) 388-9828 to schedule your PCNA Proliferating Cell Nuclear Antigen Antibody Test and take the first step toward comprehensive autoimmune assessment.
Our dedicated healthcare professionals understand the importance of timely autoimmune diagnosis and are committed to providing you with accurate, reliable results and compassionate care throughout your diagnostic journey.
