Paroxysmal Nocturnal Hemoglobinuria PNH Confirmatory Test
Understanding Paroxysmal Nocturnal Hemoglobinuria (PNH)
Paroxysmal Nocturnal Hemoglobinuria is a rare, acquired hematopoietic stem cell disorder characterized by complement-mediated hemolysis, bone marrow failure, and thrombotic complications. This life-threatening condition results from somatic mutations in the PIG-A gene, leading to deficient glycosylphosphatidylinositol (GPI)-anchored proteins on blood cell surfaces. The PNH Confirmatory Test serves as the gold standard for diagnosing this complex hematological condition, providing critical insights for appropriate treatment strategies and patient management.
What the PNH Confirmatory Test Detects
Our advanced flow cytometry-based PNH Confirmatory Test precisely measures three key biomarkers:
- CD55 (Decay Accelerating Factor): Detects deficiency in this complement regulatory protein on cell surfaces
- CD59 (Membrane Inhibitor of Reactive Lysis): Identifies absence of this crucial membrane attack complex inhibitor
- FLAER (Fluorescent Aerolysin): Specifically binds to GPI anchors, providing superior sensitivity for detecting PNH clones
The test analyzes these markers on multiple cell lineages including red blood cells, monocytes, and granulocytes, offering comprehensive assessment of PNH clone size and distribution.
Who Should Consider PNH Testing
This confirmatory test is essential for individuals experiencing:
- Unexplained hemolytic anemia with dark or red urine, particularly upon waking
- Recurrent abdominal pain, dysphagia, or erectile dysfunction
- Unexplained thrombosis in unusual locations
- Bone marrow failure syndromes including aplastic anemia
- Persistent fatigue and weakness despite adequate rest
- Laboratory findings suggesting intravascular hemolysis
Clinical Benefits of PNH Confirmatory Testing
Early and accurate PNH diagnosis through our confirmatory test provides numerous advantages:
- Precise Diagnosis: Differentiates PNH from other hemolytic anemias with high specificity
- Treatment Guidance: Informs decisions regarding complement inhibitor therapy
- Disease Monitoring: Tracks PNH clone evolution and treatment response
- Risk Assessment: Identifies patients at higher risk for thrombotic complications
- Prognostic Information: Helps predict disease course and potential complications
Understanding Your Test Results
Your PNH Confirmatory Test results will provide detailed information about:
- PNH Clone Size: Percentage of blood cells lacking GPI-anchored proteins
- Cell Lineage Involvement: Distribution of PNH clones across different blood cell types
- Disease Classification: Helps categorize PNH as classic, PNH in the setting of another bone marrow disorder, or subclinical
Our hematology specialists will provide comprehensive interpretation and guidance based on your specific results, ensuring you understand the implications for your health management.
Test Pricing and Availability
| Test Description | Regular Price | Discount Price |
|---|---|---|
| Paroxysmal Nocturnal Hemoglobinuria PNH Confirmatory Test | $376 USD | $212 USD |
Nationwide Testing Network
We provide comprehensive PNH testing services across the United States with convenient locations in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art laboratories ensure consistent, high-quality results regardless of your location.
Take Control of Your Health Today
Don’t let unexplained symptoms compromise your quality of life. Our Paroxysmal Nocturnal Hemoglobinuria PNH Confirmatory Test offers the definitive diagnosis you need for proper treatment and management. With same-day results and expert hematology consultation available, you can make informed decisions about your healthcare journey.
Ready to schedule your test? Call our dedicated healthcare team at +1(267) 388-9828 or book your appointment online today. Take the first step toward accurate diagnosis and effective management of your hematological health.
