NTRK2 Gene Fusion Test: Comprehensive Cancer Genetic Analysis
Understanding NTRK2 Gene Fusion Testing
The NTRK2 Gene Fusion Test represents a cutting-edge advancement in precision oncology, offering crucial insights into cancer genetics that can significantly impact treatment outcomes. This specialized diagnostic tool detects specific genetic rearrangements involving the neurotrophic tyrosine receptor kinase 2 (NTRK2) gene, which plays a vital role in cancer development and progression.
NTRK2 gene fusions occur when the NTRK2 gene breaks and fuses with another gene, creating abnormal proteins that drive uncontrolled cell growth and tumor formation. These genetic alterations are found across various cancer types and represent important therapeutic targets for modern cancer treatments.
What the NTRK2 Test Measures and Detects
This comprehensive genetic analysis utilizes Fluorescence In Situ Hybridization (FISH) technology to specifically identify:
- NTRK2 gene rearrangements and fusions
- Chromosomal abnormalities involving the NTRK2 locus
- Specific genetic markers that indicate susceptibility to targeted therapies
- Biomarkers for TRK inhibitor treatments
The test analyzes paraffin-embedded tumor tissue blocks, providing a detailed genetic profile of cancer cells while preserving tissue architecture for accurate interpretation.
Who Should Consider NTRK2 Testing
This genetic test is particularly important for patients with:
- Various solid tumors, including rare cancer types
- Cancers that have shown resistance to conventional treatments
- Pediatric and adult patients with advanced malignancies
- Individuals with family history of genetic cancer syndromes
- Patients seeking personalized treatment options
- Those with tumors of unknown primary origin
Symptoms and Clinical Indications
Patients experiencing unexplained weight loss, persistent pain, unusual lumps or growths, or those with diagnosed cancers should discuss NTRK2 testing with their healthcare provider. The test is especially valuable for individuals with:
- Soft tissue sarcomas
- Pediatric solid tumors
- Salivary gland cancers
- Thyroid cancers
- Infantile fibrosarcoma
- Other rare tumor types
Benefits of NTRK2 Gene Fusion Testing
Undergoing NTRK2 genetic analysis provides numerous advantages for cancer patients:
- Personalized Treatment Planning: Identifies patients who may benefit from targeted TRK inhibitor therapies
- Improved Treatment Outcomes: Enables selection of therapies specifically designed to target NTRK2 fusion proteins
- Comprehensive Genetic Profiling: Provides detailed information about tumor genetics beyond standard pathology
- Treatment Guidance: Helps oncologists make informed decisions about therapy options
- Clinical Trial Eligibility: May qualify patients for specialized clinical trials
- Prognostic Information: Offers insights into disease progression and potential treatment responses
Understanding Your Test Results
Your NTRK2 test results will provide critical information about your cancer’s genetic profile:
Positive Result
A positive result indicates the presence of NTRK2 gene fusion, suggesting that targeted TRK inhibitor therapies may be effective. Your oncologist will discuss appropriate treatment options, including FDA-approved targeted medications specifically designed for NTRK fusion-positive cancers.
Negative Result
A negative result means no NTRK2 gene fusion was detected. This information helps guide treatment decisions toward other therapeutic approaches and may indicate the need for additional genetic testing to identify other potential targets.
Inconclusive Result
In some cases, results may be inconclusive due to sample quality or technical factors. Your healthcare provider may recommend repeat testing or alternative diagnostic approaches.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| NTRK2 Gene Fusion Test | $226 USD | $300 USD |
Test Details
- Turnaround Time: 7-8 days
- Sample Type: Tumor tissue (paraffin-embedded blocks)
- Testing Method: FISH (Fluorescence In Situ Hybridization)
- Prescription Requirements: Doctor’s prescription required (exceptions for surgery, pregnancy, and international travel planning)
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our nationwide network ensures accessible genetic testing services for patients throughout the country.
Take Control of Your Cancer Treatment Journey
The NTRK2 Gene Fusion Test represents a significant advancement in precision medicine, offering hope and targeted treatment options for cancer patients. By understanding your tumor’s genetic makeup, you and your healthcare team can make more informed decisions about your treatment path.
Ready to learn more about your genetic profile? Contact our genetic counseling team today to discuss whether NTRK2 testing is right for you. Call us at +1(267) 388-9828 or book your appointment online to take the first step toward personalized cancer care.
Our experienced oncology specialists and genetic counselors are available to answer your questions and guide you through the testing process. Don’t wait to get the genetic information that could transform your cancer treatment approach.
