NTRK1 NTRK2 NTRK3 Fusion Test: Comprehensive Genetic Cancer Analysis
Understanding NTRK Gene Fusion Testing
The NTRK1 NTRK2 NTRK3 Fusion Test represents a breakthrough in precision oncology, offering comprehensive genetic analysis of neurotrophic tyrosine receptor kinase genes. These genes play a critical role in normal nervous system development and function, but when they become fused with other genes, they can drive cancer growth and progression. Our advanced testing methodology provides crucial information that can guide targeted therapy decisions for patients with various solid tumors.
What the Test Measures and Detects
This specialized test utilizes Fluorescence In Situ Hybridization (FISH) technology to identify specific genetic rearrangements involving:
- NTRK1 gene fusions – Located on chromosome 1q21-q22
- NTRK2 gene fusions – Found on chromosome 9q22.1
- NTRK3 gene fusions – Positioned on chromosome 15q25.3
The test analyzes paraffin-embedded tumor tissue blocks to detect these genetic abnormalities, which are known to be drivers in multiple cancer types. When NTRK genes fuse with partner genes, they create constitutively active TRK fusion proteins that promote uncontrolled cell growth and tumor development.
Who Should Consider This Test
This genetic testing is particularly important for patients with:
- Pediatric solid tumors including infantile fibrosarcoma and congenital mesoblastic nephroma
- Secretory breast carcinoma and mammary analog secretory carcinoma
- Thyroid cancer, particularly papillary thyroid carcinoma
- Gastrointestinal stromal tumors (GIST)
- Various sarcomas and brain tumors
- Patients with advanced or metastatic cancers where standard treatments have failed
- Individuals seeking personalized treatment options based on genetic profiling
Benefits of NTRK Fusion Testing
Undergoing NTRK gene fusion testing provides numerous advantages:
- Targeted Therapy Guidance: Identifies patients who may benefit from FDA-approved TRK inhibitors like larotrectinib and entrectinib
- Treatment Personalization: Enables oncologists to tailor treatment plans based on specific genetic abnormalities
- Improved Outcomes: Patients with NTRK fusions often show remarkable responses to targeted therapies
- Comprehensive Analysis: Simultaneously tests all three NTRK genes for complete genetic profiling
- Clinical Trial Eligibility: May qualify patients for specific clinical trials and advanced treatment protocols
Understanding Your Test Results
Your NTRK fusion test results will provide clear information about your genetic profile:
- Positive Result: Indicates the presence of NTRK gene fusion, making you a candidate for targeted TRK inhibitor therapy
- Negative Result: No NTRK gene fusions detected, suggesting alternative treatment approaches may be more appropriate
- Inconclusive Result: May require additional testing or sample collection for definitive analysis
Our genetic counselors and oncology specialists will help you understand your results and discuss next steps in your treatment journey. The typical turnaround time for results is 7-8 days from sample receipt.
Test Pricing Information
| Test Name | Regular Price | Discount Price |
|---|---|---|
| NTRK1 NTRK2 NTRK3 Fusion Test | $900 USD | $676 USD |
Convenient Testing Locations Across the USA
We have established testing facilities in all major metropolitan areas throughout the United States, including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, Charlotte, San Francisco, Indianapolis, Seattle, Denver, Washington DC, Boston, El Paso, Nashville, Detroit, Oklahoma City, Portland, Las Vegas, Memphis, Louisville, Baltimore, and Milwaukee. Our nationwide network ensures accessible genetic testing services for patients across the country.
Book Your NTRK Fusion Test Today
Take the next step in your cancer treatment journey with comprehensive genetic testing. Our specialized NTRK1 NTRK2 NTRK3 Fusion Test provides critical information that can transform your treatment approach. Contact us today to schedule your test and discuss your options with our genetic specialists.
Call or WhatsApp: +1(267) 388-9828
Important Note: This test requires a doctor’s prescription for most cases. Prescription requirements do not apply for surgery cases, pregnancy-related testing, or individuals planning international travel. Our genetic counselors are available to assist with any questions about testing requirements and insurance coverage.
