NR3C1 Gene Glucocorticoid Resistance Generalized NGS Genetic DNA Test
Understanding Glucocorticoid Resistance and NR3C1 Gene Testing
The NR3C1 Gene Glucocorticoid Resistance Generalized NGS Genetic DNA Test represents a breakthrough in molecular diagnostics for endocrine disorders. This comprehensive genetic analysis examines the NR3C1 gene, which encodes the glucocorticoid receptor—a critical protein responsible for mediating the effects of cortisol throughout the body. When mutations occur in this gene, patients develop glucocorticoid resistance syndrome, a rare condition characterized by impaired cortisol signaling despite normal or elevated cortisol levels.
What Does This Advanced Genetic Test Measure?
Our state-of-the-art Next-Generation Sequencing (NGS) technology comprehensively analyzes the entire NR3C1 gene to identify:
- Point mutations affecting glucocorticoid receptor function
- Insertions and deletions disrupting receptor binding domains
- Genetic variants impacting cortisol signaling pathways
- Inherited mutations causing familial glucocorticoid resistance
- Novel genetic alterations associated with hormone resistance
Who Should Consider NR3C1 Genetic Testing?
This specialized genetic test is recommended for individuals presenting with:
- Unexplained hypertension with hypokalemia (low potassium)
- Clinical features of Cushing’s syndrome without elevated cortisol
- Androgen excess symptoms in females (hirsutism, acne, menstrual irregularities)
- Family history of glucocorticoid resistance or similar endocrine disorders
- Resistance to standard glucocorticoid therapy
- Complex metabolic disorders affecting multiple organ systems
Clinical Benefits of NR3C1 Gene Analysis
Undergoing NR3C1 genetic testing provides numerous clinical advantages:
- Precise Diagnosis: Confirms genetic basis for glucocorticoid resistance
- Personalized Treatment: Guides targeted therapeutic interventions
- Family Risk Assessment: Identifies inheritance patterns and carrier status
- Prognostic Information: Helps predict disease progression and complications
- Therapeutic Monitoring: Enables treatment response evaluation
Understanding Your Test Results
Our comprehensive genetic counseling service helps interpret your NR3C1 test results:
- Positive Result: Identifies pathogenic mutation confirming diagnosis
- Variant of Uncertain Significance: Requires additional family studies
- Negative Result: Suggests alternative diagnoses may be considered
- Carrier Status: Important for family planning decisions
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Comprehensive Testing Process
Our NR3C1 genetic testing follows a meticulous protocol:
- Sample Type: Blood, Extracted DNA, or One Drop Blood on FTA Card
- Turnaround Time: 3 to 4 Weeks
- Technology: Advanced Next-Generation Sequencing (NGS)
- Pre-test Requirements: Clinical history and genetic counseling session
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network of certified genetic counselors and medical professionals ensures consistent, high-quality care regardless of location.
Take Control of Your Endocrine Health Today
Don’t let unexplained symptoms compromise your quality of life. The NR3C1 Gene Glucocorticoid Resistance Test provides definitive answers for complex endocrine disorders. Our team of genetic specialists, endocrinologists, and certified counselors are ready to guide you through every step of the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your NR3C1 genetic test. Take the first step toward personalized endocrine care and comprehensive family health management.
