NR1H4 Gene Intrahepatic Cholestasis of Pregnancy NGS Genetic DNA Test
Understanding NR1H4 Gene Testing for Pregnancy Liver Health
The NR1H4 Gene Intrahepatic Cholestasis of Pregnancy NGS Genetic DNA Test represents a significant advancement in prenatal genetic screening. This specialized test focuses on identifying mutations in the NR1H4 gene, which plays a crucial role in bile acid metabolism and liver function during pregnancy. Intrahepatic cholestasis of pregnancy (ICP) is a serious liver condition that affects approximately 1-2% of pregnant women in the United States, characterized by impaired bile flow and elevated liver enzymes.
What Does This Test Measure and Detect?
This comprehensive genetic analysis utilizes Next-Generation Sequencing (NGS) technology to examine the NR1H4 gene for specific mutations associated with intrahepatic cholestasis of pregnancy. The test detects:
- Pathogenic variants in the NR1H4 gene that disrupt bile acid transport
- Genetic mutations affecting the farnesoid X receptor (FXR) function
- Variations that impair bile acid synthesis and secretion
- Genetic markers associated with increased risk of pregnancy complications
Who Should Consider This Genetic Test?
This test is particularly recommended for pregnant women experiencing specific symptoms or with relevant medical history:
- Women experiencing intense itching, especially on palms and soles, during pregnancy
- Patients with elevated liver enzymes or abnormal liver function tests during pregnancy
- Women with a family history of intrahepatic cholestasis of pregnancy
- Patients who experienced ICP in previous pregnancies
- Women with unexplained jaundice or dark urine during pregnancy
- Those with risk factors for pregnancy-related liver disorders
Clinical Benefits of NR1H4 Genetic Testing
Undergoing this genetic test provides numerous advantages for maternal and fetal health management:
- Early Risk Assessment: Identify genetic predisposition to ICP before severe symptoms develop
- Personalized Treatment Planning: Enable targeted interventions and monitoring protocols
- Improved Pregnancy Outcomes: Reduce risks of preterm birth and fetal complications
- Informed Family Planning: Provide genetic counseling for future pregnancies
- Comprehensive Care Coordination: Facilitate collaboration between obstetricians and hepatologists
Understanding Your Test Results
Our genetic counseling team provides comprehensive interpretation of your NR1H4 gene test results:
- Positive Result: Indicates the presence of NR1H4 gene mutations associated with ICP risk. This enables proactive management and specialized prenatal care.
- Negative Result: Suggests no detected mutations in the NR1H4 gene, though other factors may still contribute to liver issues during pregnancy.
- Variant of Uncertain Significance: Some genetic variations may require additional family studies or clinical correlation.
All results are accompanied by detailed explanations and recommendations from our certified genetic counselors.
Test Pricing and Availability
| Test Feature | Details |
|---|---|
| Test Name | NR1H4 Gene Intrahepatic Cholestasis of Pregnancy NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
Nationwide Testing Availability
We have conveniently located branches across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our state-of-the-art genetic testing facilities ensure consistent, high-quality results regardless of your location.
Take Control of Your Pregnancy Health Today
Don’t let uncertainty about pregnancy-related liver conditions affect your peace of mind. Our NR1H4 genetic test provides the clarity and information you need for optimal pregnancy management. Schedule your appointment today and take the first step toward comprehensive prenatal genetic screening.
Call or WhatsApp us now at +1(267) 388-9828 to book your NR1H4 Gene Intrahepatic Cholestasis of Pregnancy NGS Genetic DNA Test. Our genetic counseling team is ready to answer your questions and guide you through the testing process.
