MSH2 Gene Colorectal Cancer Hereditary Nonpolyposis Type 1 NGS Genetic DNA Test
Comprehensive Introduction to Hereditary Cancer Screening
The MSH2 Gene Colorectal Cancer Hereditary Nonpolyposis Type 1 NGS Genetic DNA Test represents a breakthrough in preventive oncology, offering individuals with family cancer histories the opportunity to understand their genetic predisposition to Lynch syndrome. This advanced diagnostic tool utilizes cutting-edge Next-Generation Sequencing technology to analyze the MSH2 gene, a critical component of the DNA mismatch repair system. When this gene contains mutations, it significantly increases lifetime cancer risks, particularly for colorectal and endometrial cancers.
Understanding your genetic makeup provides unprecedented power in cancer prevention and early detection strategies. This test serves as a cornerstone for personalized medicine, enabling healthcare providers to develop targeted surveillance plans and preventive measures based on individual genetic profiles. The importance of this testing extends beyond individual health to family health planning, as hereditary cancer syndromes can affect multiple generations.
What This Advanced Genetic Test Detects
The MSH2 Gene Colorectal Cancer Hereditary Nonpolyposis Type 1 NGS Genetic DNA Test specifically identifies:
- Pathogenic mutations in the MSH2 gene associated with Lynch syndrome
- DNA mismatch repair deficiencies that lead to microsatellite instability
- Genetic variants that increase colorectal cancer risk by 40-80%
- Hereditary predisposition to endometrial, ovarian, gastric, and urinary tract cancers
- Autosomal dominant inheritance patterns within families
Who Should Consider MSH2 Genetic Testing?
This comprehensive genetic screening is particularly recommended for individuals who meet any of the following criteria:
Family History Indicators
- Multiple relatives with colorectal cancer across generations
- Early-onset colorectal cancer (before age 50) in family members
- Family history of Lynch syndrome-associated cancers (endometrial, ovarian, gastric)
- Multiple primary cancers in the same individual within the family
- Known MSH2 mutation carriers among blood relatives
Personal Health Factors
- Diagnosis of colorectal cancer before age 50
- Multiple Lynch syndrome-related cancers in the same person
- Abnormal tumor testing showing microsatellite instability
- Strong family cancer history without clear pattern
- Planning for cancer prevention strategies
Significant Benefits of MSH2 Genetic Testing
Undergoing MSH2 genetic testing provides numerous advantages for proactive health management:
Early Detection and Prevention
- Enables earlier and more frequent cancer screening protocols
- Facilitates preventive surgeries when medically appropriate
- Allows for lifestyle modifications to reduce cancer risk
- Provides opportunity for chemoprevention strategies
Family Health Planning
- Identifies at-risk family members for targeted screening
- Supports reproductive decision-making and family planning
- Enables cascade testing within affected families
- Provides clarity for future generations
Personalized Medical Management
- Tailors cancer surveillance schedules based on genetic risk
- Informs treatment decisions if cancer develops
- Reduces anxiety through knowledge and proactive planning
- Connects patients with specialized hereditary cancer programs
Understanding Your Genetic Test Results
Your MSH2 genetic test results will fall into one of several categories, each with specific implications for your health management:
Positive Result
A positive result indicates the presence of a pathogenic MSH2 mutation. This confirms Lynch syndrome diagnosis and significantly increases cancer risks. Management includes enhanced cancer surveillance, consideration of risk-reducing surgeries, and family testing recommendations.
Negative Result
A negative result in someone with a known family mutation indicates the individual did not inherit the familial mutation. Their cancer risk returns to population levels, though general screening recommendations still apply.
Variant of Uncertain Significance (VUS)
A VUS result means a genetic change was found, but its clinical significance is unknown. Management follows family cancer history rather than genetic results, and periodic reclassification may occur as research advances.
No Mutation Detected
When no mutation is found in someone without a known family mutation, Lynch syndrome cannot be ruled out completely. Management should be based on personal and family cancer history.
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| MSH2 Gene Colorectal Cancer Hereditary Nonpolyposis Type 1 NGS Genetic DNA Test – Discount Price | $500 |
| MSH2 Gene Colorectal Cancer Hereditary Nonpolyposis Type 1 NGS Genetic DNA Test – Regular Price | $700 |
Test Specifications
- Turnaround Time: 3 to 4 Weeks
- Sample Type: Blood, Extracted DNA, or One Drop Blood on FTA Card
- Methodology: Next-Generation Sequencing (NGS) Technology
- Specialty: Oncologist and Genetics Department
Pre-Test Requirements
Before undergoing testing, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session with our certified genetic counselors
- Development of detailed family pedigree chart
- Discussion of testing implications and potential outcomes
- Informed consent process
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, San Francisco, and many more. Our network of certified genetic counselors and healthcare providers ensures you receive comprehensive care regardless of your location.
Take Control of Your Genetic Health Today
Don’t let uncertainty about your hereditary cancer risk dictate your future. The MSH2 Gene Colorectal Cancer Hereditary Nonpolyposis Type 1 NGS Genetic DNA Test provides the clarity needed to make informed health decisions and implement effective cancer prevention strategies. Our team of genetic specialists is ready to guide you through every step of the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your test. Early detection through genetic testing could save your life and protect your family’s health for generations to come.
