LRBA Gene Immunodeficiency Common Variable Type 8 NGS Genetic DNA Test
Comprehensive Genetic Testing for Immune System Disorders
The LRBA Gene Immunodeficiency Common Variable Type 8 NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for immune system disorders. This advanced test specifically targets mutations in the LRBA (Lipopolysaccharide Responsive Beige-like Anchor Protein) gene, which plays a critical role in regulating immune cell function and preventing autoimmune responses. When the LRBA gene contains pathogenic variants, it can lead to Common Variable Immunodeficiency Type 8 (CVID8), a serious condition characterized by impaired antibody production and increased susceptibility to infections.
What This Test Measures and Detects
Our comprehensive NGS-based genetic analysis examines the entire LRBA gene sequence to identify:
- Pathogenic mutations affecting LRBA protein function
- Single nucleotide variants (SNVs) and small insertions/deletions
- Copy number variations (CNVs) impacting gene dosage
- Regulatory region abnormalities affecting gene expression
- Compound heterozygous or homozygous mutations
The test utilizes state-of-the-art Next-Generation Sequencing technology, providing unparalleled accuracy in detecting even rare genetic variants that conventional testing methods might miss. This comprehensive approach ensures thorough evaluation of the LRBA gene’s integrity and function.
Who Should Consider This Genetic Test
This specialized genetic test is recommended for individuals experiencing:
- Recurrent bacterial, viral, or fungal infections requiring frequent antibiotic treatment
- Unexplained autoimmune manifestations including cytopenias, arthritis, or inflammatory bowel disease
- Family history of primary immunodeficiency disorders
- Early-onset immune dysregulation with multiple organ involvement
- Poor response to conventional immune therapies
- Developmental delays or growth abnormalities with immune component
- Chronic gastrointestinal symptoms with immune-mediated inflammation
Clinical Benefits of LRBA Genetic Testing
Undergoing LRBA gene testing provides numerous clinical advantages:
- Accurate Diagnosis: Confirms or rules out LRBA deficiency as the underlying cause of immune dysfunction
- Personalized Treatment: Guides targeted therapeutic approaches including immunosuppressive regimens
- Family Planning: Enables informed reproductive decisions through genetic counseling
- Prognostic Information: Helps predict disease progression and potential complications
- Therapeutic Monitoring: Assists in evaluating treatment efficacy and adjusting management strategies
- Early Intervention: Facilitates prompt initiation of appropriate therapies before irreversible damage occurs
Understanding Your Test Results
Our comprehensive genetic report provides detailed interpretation of your LRBA gene analysis:
- Positive Result: Identifies pathogenic mutations confirming LRBA deficiency diagnosis, requiring specialized immunology care
- Negative Result: No LRBA mutations detected, suggesting alternative causes for immune symptoms
- Variant of Uncertain Significance (VUS): Identifies genetic changes with unclear clinical impact, requiring further evaluation
- Carrier Status: Identifies individuals with single mutation copies who may pass the condition to offspring
All results include detailed clinical correlations and recommendations for follow-up care with qualified immunology specialists.
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Nationwide Testing Availability
We proudly offer comprehensive genetic testing services across the United States with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified collection centers ensures accessible testing for patients nationwide.
Take Control of Your Immune Health Today
Don’t let unexplained immune symptoms compromise your quality of life. Our LRBA Gene Immunodeficiency Common Variable Type 8 NGS Genetic DNA Test provides the clarity needed for proper diagnosis and effective treatment planning. With results available in 3-4 weeks and multiple sample collection options including blood, extracted DNA, or FTA card blood spots, getting tested has never been more convenient.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic consultation and testing appointment. Our experienced genetic counselors are ready to guide you through the testing process and help you understand your results.
