LEP Gene Obesity due to Leptin Deficiency NGS Genetic DNA Test
Comprehensive Genetic Analysis for Severe Obesity
The LEP Gene Obesity due to Leptin Deficiency NGS Genetic DNA Test represents a breakthrough in precision medicine for individuals struggling with severe, early-onset obesity. This advanced diagnostic tool utilizes next-generation sequencing technology to identify mutations in the LEP gene that disrupt leptin production, a critical hormone regulating appetite and energy balance. Leptin deficiency represents one of the most significant genetic causes of severe obesity, and accurate diagnosis through this test can transform treatment approaches and improve patient outcomes.
What This Test Measures and Detects
This comprehensive genetic test specifically targets the LEP gene located on chromosome 7q31.3, which encodes the leptin hormone. Through sophisticated NGS technology, the test analyzes:
- Complete coding regions of the LEP gene
- Exon-intron boundaries and splice site mutations
- Point mutations, insertions, and deletions affecting leptin production
- Genetic variants associated with congenital leptin deficiency
The test provides detailed information about specific genetic mutations that impair leptin signaling, leading to uncontrolled appetite and severe weight gain from early childhood.
Who Should Consider This Genetic Test
Clinical Indications and Symptoms
This test is particularly recommended for individuals presenting with:
- Severe obesity developing in infancy or early childhood
- Persistent hyperphagia (excessive hunger) despite adequate food intake
- Family history of severe obesity across multiple generations
- Normal or advanced linear growth despite extreme weight gain
- Hypogonadotropic hypogonadism in older children and adults
- Impaired immune function and recurrent infections
- Resistance to conventional weight management strategies
Benefits of Genetic Testing for Leptin Deficiency
Undergoing the LEP gene obesity test provides numerous advantages for patients and healthcare providers:
- Accurate Diagnosis: Confirms or rules out genetic leptin deficiency as the underlying cause of severe obesity
- Personalized Treatment: Enables targeted therapeutic approaches, including potential leptin replacement therapy
- Family Planning: Provides crucial information for genetic counseling and family planning decisions
- Early Intervention: Facilitates early diagnosis and intervention in affected children
- Comprehensive Understanding: Helps differentiate genetic obesity from other forms of weight-related conditions
Understanding Your Test Results
Interpretation and Clinical Implications
Your genetic test results will be carefully analyzed and interpreted by our team of genetic specialists:
- Positive Result: Identification of pathogenic mutations in the LEP gene confirms congenital leptin deficiency, opening pathways for specific treatment options
- Negative Result: Absence of LEP gene mutations suggests other genetic or environmental factors contributing to obesity
- Variant of Uncertain Significance: Some genetic changes may require additional family studies for proper interpretation
All results are accompanied by comprehensive genetic counseling to ensure proper understanding and appropriate next steps for management.
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | LEP Gene Obesity due to Leptin Deficiency NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements and Preparation
To ensure optimal testing conditions and accurate results, we require:
- Complete clinical history of the patient undergoing testing
- Genetic counseling session to document family pedigree
- Identification of family members affected by severe obesity
- Discussion of potential implications and treatment options
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network of certified genetic testing facilities ensures consistent quality and reliable results nationwide.
Take Control of Your Health Journey
Understanding the genetic basis of severe obesity can be life-changing. The LEP Gene Obesity due to Leptin Deficiency NGS Genetic DNA Test provides the clarity needed to pursue targeted treatment strategies and improve quality of life. Our team of genetic specialists and endocrinologists are committed to supporting you through every step of the testing process.
Ready to begin your genetic testing journey? Contact our genetic counseling team today at +1(267) 388-9828 or book your appointment online to schedule your comprehensive LEP gene analysis.
