Irinotecan Toxicity Assessment UGT1A1 Genotyping Gilbert Syndrome
Understanding Your Genetic Risk for Chemotherapy Toxicity
The Irinotecan Toxicity Assessment UGT1A1 Genotyping Gilbert Syndrome test represents a breakthrough in personalized medicine, offering crucial insights into how your body processes specific medications, particularly the chemotherapy drug irinotecan. This advanced genetic analysis helps healthcare providers tailor cancer treatment plans to your unique genetic makeup, potentially preventing severe side effects and improving treatment outcomes.
What This Test Measures and Detects
This comprehensive genetic test specifically analyzes variations in the UGT1A1 gene, which encodes the enzyme responsible for metabolizing bilirubin and certain medications, including irinotecan. The test identifies:
- UGT1A1*28 and other genetic polymorphisms associated with reduced enzyme activity
- Genetic markers for Gilbert Syndrome, a common inherited condition affecting bilirubin metabolism
- Your individual risk profile for developing severe toxicity from irinotecan chemotherapy
- Genetic factors that influence drug metabolism and clearance rates
Who Should Consider This Genetic Test
This test is particularly important for individuals in the following situations:
- Cancer patients scheduled to receive irinotecan-based chemotherapy for colorectal, pancreatic, or lung cancers
- Individuals with family history of Gilbert Syndrome or unexplained jaundice
- Patients experiencing unexplained elevated bilirubin levels
- Those with previous adverse reactions to medications metabolized by UGT1A1 enzymes
- Individuals planning chemotherapy who want personalized dosing recommendations
Key Benefits of Genetic Testing
Undergoing this genetic assessment provides numerous advantages for your healthcare journey:
- Personalized Chemotherapy Dosing: Enables oncologists to adjust irinotecan doses based on your genetic profile
- Reduced Toxicity Risk: Helps prevent severe side effects like neutropenia and diarrhea
- Improved Treatment Outcomes: Optimizes chemotherapy effectiveness while minimizing complications
- Early Risk Identification: Identifies genetic predispositions before treatment begins
- Comprehensive Health Insights: Provides information about Gilbert Syndrome and bilirubin metabolism
Understanding Your Test Results
Your genetic test results will fall into one of several categories, each with specific implications for your treatment:
- Normal UGT1A1 Activity: Indicates typical metabolism of irinotecan, allowing for standard dosing protocols
- Intermediate Metabolizer: Suggests reduced enzyme activity, requiring careful dose monitoring
- Poor Metabolizer: Significantly reduced enzyme function, necessitating substantial dose reductions or alternative treatments
- Gilbert Syndrome Carrier: Identifies genetic variations associated with mild bilirubin elevation
It’s essential to discuss your results with your healthcare provider, who can interpret them in the context of your overall health and treatment plan.
Test Pricing and Availability
| Test Component | Price |
|---|---|
| Discount Price | $188 USD |
| Regular Price | $250 USD |
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our state-of-the-art laboratories ensure accurate results with a standard turnaround time of 7-8 days.
Take Control of Your Treatment Journey
Don’t leave your chemotherapy outcomes to chance. The Irinotecan Toxicity Assessment UGT1A1 Genotyping Gilbert Syndrome test provides the genetic information needed to optimize your treatment plan and minimize risks. Our experienced genetic counselors and healthcare professionals are ready to guide you through the testing process and help you understand your results.
Ready to schedule your genetic test? Contact us today at +1(267) 388-9828 to book your appointment or speak with our genetic specialists. Take the first step toward personalized cancer treatment and improved health outcomes.
Note: This test requires a doctor’s prescription for most cases. Prescription requirements may not apply for surgery preparation, pregnancy-related testing, or international travel documentation purposes.
