Immunohistochemistry IgG4 Test: Comprehensive Diagnostic Analysis
Understanding the Immunohistochemistry IgG4 Test
The Immunohistochemistry IgG4 Test represents a cutting-edge diagnostic approach for identifying IgG4-related diseases, a group of complex autoimmune conditions that can affect multiple organ systems. This specialized laboratory technique utilizes advanced immunohistochemical staining methods to detect and quantify IgG4-positive plasma cells within tissue samples, providing crucial diagnostic information that guides treatment decisions and patient management strategies.
What Does the Immunohistochemistry IgG4 Test Measure?
This sophisticated diagnostic test specifically identifies and quantifies IgG4-positive plasma cells in tissue specimens through precise immunohistochemical staining techniques. The test measures:
- Presence and distribution of IgG4-positive plasma cells
- IgG4 to IgG ratio within tissue samples
- Pattern of inflammatory cell infiltration
- Tissue architecture changes associated with IgG4-related disease
- Storiform fibrosis characteristics
- Obliterative phlebitis patterns
Who Should Consider IgG4 Immunohistochemistry Testing?
This specialized test is recommended for individuals presenting with symptoms suggestive of IgG4-related diseases, including:
- Unexplained organ enlargement or masses
- Chronic inflammatory conditions affecting multiple organs
- Autoimmune symptoms without clear diagnosis
- Suspected IgG4-related pancreatitis, sialadenitis, or retroperitoneal fibrosis
- Patients with elevated serum IgG4 levels requiring tissue confirmation
- Individuals with treatment-resistant inflammatory conditions
Clinical Indications and Symptoms
Patients experiencing the following symptoms may benefit from IgG4 immunohistochemistry testing:
- Persistent swelling of salivary or lacrimal glands
- Unexplained pancreatic inflammation or dysfunction
- Retroperitoneal fibrosis or mediastinal involvement
- Orbital inflammation or thyroid enlargement
- Multiple organ system involvement with inflammatory features
- Autoimmune pancreatitis symptoms
Benefits of Immunohistochemistry IgG4 Testing
Choosing the Immunohistochemistry IgG4 Test provides numerous advantages for accurate diagnosis and treatment planning:
- Precise Diagnosis: Enables definitive diagnosis of IgG4-related diseases
- Treatment Guidance: Informs appropriate immunosuppressive therapy decisions
- Differential Diagnosis: Helps distinguish from malignancies and other inflammatory conditions
- Prognostic Information: Provides insights into disease severity and progression
- Monitoring Tool: Assists in evaluating treatment response and disease activity
- Comprehensive Analysis: Offers detailed tissue-level information beyond serum testing
Understanding Your Test Results
Your Immunohistochemistry IgG4 Test results will provide detailed information about IgG4-positive plasma cell presence and distribution:
- Positive Result: Indicates significant IgG4-positive plasma cell infiltration, supporting IgG4-related disease diagnosis
- Elevated IgG4/IgG Ratio: Suggests IgG4-related disease when ratio exceeds established thresholds
- Negative Result: May indicate alternative diagnoses or require additional testing
- Quantitative Assessment: Provides cell counts per high-power field for precise evaluation
- Pattern Analysis: Evaluates tissue architecture and inflammatory patterns
Interpretation Guidelines
Results are interpreted by experienced pathologists considering:
- IgG4-positive plasma cell density
- IgG4 to total IgG ratio
- Characteristic histopathological features
- Clinical correlation with patient symptoms
- Integration with serum IgG4 levels and imaging findings
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Immunohistochemistry IgG4 Test | $88 USD | $112 USD |
Turnaround Time and Sample Requirements
Our laboratory maintains efficient processing with the following timelines:
- Sample Acceptance: Daily by 6:00 PM
- Standard Tissue Block: 5 days
- Tissue Biopsy: 5 days
- Complex Tissue Samples: 7 days
Sample Collection and Submission
For accurate testing, please submit:
- Tumor tissue preserved in 10% formal-saline solution
- Formalin-fixed paraffin-embedded tissue blocks
- Ship samples at room temperature with proper packaging
- Include complete histopathology report
- Provide detailed biopsy site information
- Submit comprehensive clinical history
Nationwide Testing Availability
We proudly offer Immunohistochemistry IgG4 testing services across the United States through our extensive network of diagnostic centers. Our facilities are conveniently located in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, and numerous other cities nationwide. Each location maintains the same high standards of quality, accuracy, and professional service.
Book Your Immunohistochemistry IgG4 Test Today
Take the first step toward accurate diagnosis and effective treatment planning. Our experienced team of pathologists and laboratory specialists are ready to provide you with comprehensive IgG4 testing services. Contact us today to schedule your test or discuss your diagnostic needs with our medical professionals.
Call or WhatsApp: +1(267) 388-9828
Don’t let uncertainty about your symptoms delay proper diagnosis. The Immunohistochemistry IgG4 Test provides the clarity needed for effective treatment decisions and improved patient outcomes. Reach out to our dedicated team to learn more about this essential diagnostic tool and schedule your testing appointment at a location convenient for you.
