Immunohistochemistry Glypican-3 (GPC3) Test
Understanding the Glypican-3 (GPC3) Test
The Immunohistochemistry Glypican-3 (GPC3) Test represents a breakthrough in liver cancer diagnostics, offering precise detection capabilities for hepatocellular carcinoma (HCC). This specialized laboratory procedure utilizes advanced immunohistochemistry techniques to identify the presence of Glypican-3, a cell surface proteoglycan that serves as a highly specific biomarker for malignant liver tumors.
What Does the GPC3 Test Measure?
The GPC3 test specifically detects the expression of Glypican-3 protein in tissue samples. This biomarker is:
- A cell surface heparan sulfate proteoglycan
- Highly expressed in hepatocellular carcinoma cells
- Minimally present in normal liver tissue
- Rarely expressed in benign liver conditions
- Useful for distinguishing HCC from metastatic liver tumors
Clinical Importance and Applications
The GPC3 test plays a vital role in modern oncology practice by providing critical diagnostic information that directly impacts patient management decisions. Its importance extends beyond simple detection to comprehensive tumor characterization and treatment guidance.
Who Should Consider This Test?
This test is recommended for patients presenting with:
- Liver masses or nodules detected on imaging studies
- Suspected hepatocellular carcinoma based on clinical findings
- Elevated alpha-fetoprotein (AFP) levels with inconclusive imaging
- Differentiation needed between HCC and benign liver lesions
- History of chronic liver disease with new liver abnormalities
- Monitoring of treatment response in known HCC cases
Benefits of GPC3 Testing
Choosing the Immunohistochemistry GPC3 Test offers multiple advantages for both patients and healthcare providers:
Diagnostic Accuracy
- High specificity for hepatocellular carcinoma (85-90%)
- Superior sensitivity compared to traditional markers
- Reduced need for repeated biopsies
- Clear differentiation from metastatic cancers
Clinical Management Advantages
- Guides appropriate treatment selection
- Helps determine prognosis and disease staging
- Supports personalized medicine approaches
- Facilitates early intervention strategies
Test Procedure and Sample Requirements
The GPC3 test requires proper sample collection and handling to ensure accurate results:
Sample Specifications
- Sample Type: Tumor tissue in 10% formal-saline OR formalin-fixed paraffin-embedded block
- Shipping: Room temperature transport
- Required Documentation: Histopathology report, biopsy site information, and clinical history
Turnaround Time
- Block Samples: 5 days
- Tissue Biopsy: 5 days
- Large Complex Tissue: 7 days
- Sample Processing: Daily by 6 PM
Understanding Your Test Results
Interpreting GPC3 test results requires professional medical expertise, but here’s general guidance:
Positive Result Interpretation
- Strong staining indicates high likelihood of hepatocellular carcinoma
- Supports diagnosis of primary liver cancer
- May correlate with tumor aggressiveness
- Helps exclude metastatic liver disease
Negative Result Interpretation
- Does not completely rule out HCC (consider other diagnostic methods)
- Suggests alternative diagnoses should be considered
- May indicate well-differentiated HCC variants
- Requires correlation with clinical and radiological findings
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $88 |
| Regular Price | $112 |
Nationwide Accessibility
We maintain comprehensive testing facilities across the United States, ensuring convenient access to advanced diagnostic services in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network of certified laboratories guarantees consistent quality and reliable results nationwide.
Take Action for Your Health
Early and accurate diagnosis is crucial for effective liver cancer management. The Immunohistochemistry Glypican-3 Test provides the precision needed for confident clinical decisions. Don’t delay in obtaining this vital diagnostic information.
Book your Immunohistochemistry Glypican-3 Test today by calling our dedicated healthcare line at +1(267) 388-9828. Our experienced staff will guide you through the scheduling process and answer any questions about sample requirements, pricing, or result interpretation.
Take the first step toward precise diagnosis and personalized treatment planning. Contact us now to schedule your test and benefit from our specialized oncology pathology services.
