Immunohistochemistry Glial Fibrillary Acidic Protein GFAP Test
Understanding GFAP Immunohistochemistry Testing
The Immunohistochemistry Glial Fibrillary Acidic Protein (GFAP) Test represents a cornerstone in modern neuropathological diagnosis, providing essential insights into central nervous system tumors. This sophisticated laboratory technique utilizes specific antibodies to detect GFAP expression, a critical intermediate filament protein predominantly found in astrocytes and other glial cells. The test’s precision in identifying glial cell lineage makes it indispensable for accurate brain and spinal tumor classification.
Scientific Foundation and Clinical Significance
GFAP serves as a specific marker for cells of glial origin, particularly astrocytes. When tissue samples undergo immunohistochemical staining, the presence of GFAP helps pathologists differentiate between various tumor types, guiding treatment decisions and prognostic assessments. This test’s reliability in confirming glial tumor diagnosis has made it a standard component in comprehensive neuro-oncological evaluation protocols worldwide.
What the GFAP Test Detects and Measures
The GFAP Immunohistochemistry Test specifically identifies and quantifies the expression of glial fibrillary acidic protein within tissue specimens. This detection provides critical diagnostic information:
- Glial Cell Identification: Confirms the presence of astrocytes and other glial cell types
- Tumor Classification: Differentiates between gliomas, astrocytomas, and other CNS tumors
- Cell Lineage Determination: Helps distinguish glial tumors from metastatic cancers or other neurological conditions
- Diagnostic Confirmation: Provides definitive evidence for glioma diagnosis and grading
Who Should Consider GFAP Testing
This specialized test is recommended for patients presenting with specific clinical scenarios and symptoms:
Clinical Indications
- Patients with suspected primary brain tumors or spinal cord tumors
- Individuals experiencing unexplained neurological symptoms including:
- Persistent headaches with increasing severity
- Seizures without previous history
- Progressive neurological deficits
- Vision changes or coordination problems
- Cases requiring differentiation between primary CNS tumors and metastatic disease
- Patients with abnormal imaging findings suggesting glial tumors
- Individuals needing tumor grading and classification for treatment planning
Benefits of GFAP Immunohistochemistry Testing
Choosing GFAP testing provides numerous advantages for accurate diagnosis and optimal patient care:
- Precise Diagnosis: Enables accurate identification of glial cell tumors
- Treatment Guidance: Informs appropriate therapeutic strategies based on tumor type
- Prognostic Information: Helps predict disease course and treatment response
- Differential Diagnosis: Distinguishes between various CNS tumor types
- Comprehensive Evaluation: Complements other diagnostic modalities for complete assessment
- Early Detection: Facilitates timely intervention for better outcomes
Understanding Your GFAP Test Results
Interpreting GFAP immunohistochemistry results requires professional medical expertise, but general guidance includes:
Positive GFAP Expression
- Indicates presence of glial cell tumors such as astrocytomas or gliomas
- Supports diagnosis of primary CNS tumors of glial origin
- Helps in tumor grading and classification
Negative GFAP Expression
- Suggests absence of glial cell differentiation
- May indicate metastatic tumors, meningiomas, or other non-glial neoplasms
- Requires additional testing for comprehensive diagnosis
Interpretation Context
Results should always be interpreted in conjunction with clinical history, imaging findings, and other pathological features by qualified neuropathologists and oncologists.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $76 |
| Regular Price | $126 |
Turnaround Time
- Sample Submission: Daily by 6 PM
- Block Processing: 5 days
- Tissue Biopsy: 5 days
- Complex Tissue: 7 days
Sample Requirements
Submit tumor tissue in 10% formal-saline OR formalin-fixed paraffin-embedded block. Ship at room temperature. Essential documentation includes:
- Copy of Histopathology report
- Site of biopsy information
- Complete clinical history
Nationwide Accessibility
We maintain diagnostic centers across all major cities in the United States, ensuring convenient access to GFAP testing services. Our network includes facilities in New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose, providing comprehensive neuropathological services to patients nationwide.
Take Action for Accurate Diagnosis
Don’t leave neurological concerns unanswered. The GFAP Immunohistochemistry Test provides the clarity needed for proper diagnosis and treatment planning. Our team of experienced pathologists and oncologists stands ready to assist you with comprehensive neuro-oncological evaluation.
Book your GFAP test today by calling +1(267) 388-9828 or via WhatsApp. Take the first step toward precise diagnosis and effective treatment planning.