Immunohistochemistry Epidermal Growth Factor Receptor EGFR Test
Understanding EGFR Testing for Cancer Treatment
The Immunohistochemistry Epidermal Growth Factor Receptor (EGFR) Test represents a breakthrough in personalized cancer medicine, providing critical insights into tumor biology that directly influence treatment decisions. This advanced diagnostic procedure examines cancer tissue samples to detect the presence and expression levels of EGFR proteins, which play a pivotal role in cancer cell growth and proliferation.
What is EGFR and Why Does It Matter?
Epidermal Growth Factor Receptor (EGFR) is a protein found on the surface of cells that helps them grow and divide. In many cancers, EGFR becomes overactive or mutated, driving uncontrolled tumor growth. The Immunohistochemistry EGFR Test uses specialized antibodies to visualize and quantify EGFR expression in tumor tissue, providing oncologists with essential information about the cancer’s molecular characteristics.
What the EGFR Test Measures and Detects
This sophisticated diagnostic test specifically evaluates:
- EGFR protein expression levels in cancer cells
- Patterns of EGFR distribution within tumor tissue
- Intensity of EGFR staining, indicating protein concentration
- Cellular localization of EGFR receptors
- Potential for response to EGFR-targeted therapies
Technical Methodology
The test employs immunohistochemistry (IHC) techniques, where thin sections of tumor tissue are treated with specific antibodies that bind to EGFR proteins. These antibody complexes are then visualized using chromogenic detection systems, allowing pathologists to assess EGFR expression patterns under microscopic examination.
Who Should Consider EGFR Testing
This test is particularly important for patients with:
- Newly diagnosed non-small cell lung cancer (NSCLC)
- Squamous cell carcinoma of the head and neck
- Glioblastoma multiforme (brain tumors)
- Colorectal cancer being evaluated for treatment options
- Pancreatic cancer requiring comprehensive biomarker profiling
- Any solid tumor where EGFR-targeted therapy is being considered
Clinical Indications and Symptoms
Patients experiencing persistent cough, unexplained weight loss, breathing difficulties, neurological symptoms, or those with confirmed cancer diagnoses should discuss EGFR testing with their oncologist. Early biomarker testing can significantly impact treatment planning and outcomes.
Benefits of EGFR Immunohistochemistry Testing
- Personalized Treatment Planning: Identifies patients who may benefit from EGFR inhibitor therapies
- Improved Survival Outcomes: Targeted therapies based on EGFR status show superior results compared to conventional chemotherapy
- Reduced Treatment Side Effects: More specific targeting of cancer cells minimizes damage to healthy tissues
- Cost-Effective Care: Avoids unnecessary treatments for patients unlikely to respond
- Comprehensive Cancer Profiling: Provides valuable information about tumor biology and behavior
- Treatment Monitoring: Can be used to assess response to therapy over time
Understanding Your EGFR Test Results
Your EGFR test results will typically include:
Interpretation Guidelines
- Positive EGFR Expression: Indicates the presence of EGFR proteins in tumor cells, suggesting potential responsiveness to EGFR-targeted therapies
- Negative EGFR Expression: Suggests limited benefit from EGFR inhibitors, guiding consideration of alternative treatment approaches
- Staining Intensity Scores: Pathologists grade EGFR expression as 0, 1+, 2+, or 3+ based on staining intensity and distribution
- Clinical Correlation: Results must be interpreted in context with other clinical and pathological findings
Next Steps After Testing
Your oncologist will discuss the implications of your EGFR test results and develop a personalized treatment plan. Positive results may lead to consideration of EGFR inhibitor medications, while negative results help avoid ineffective treatments and associated side effects.
Test Pricing and Availability
| Test Name | Regular Price | Discount Price |
|---|---|---|
| Immunohistochemistry Epidermal Growth Factor Receptor EGFR Test | $112 USD | $88 USD |
Turnaround Time and Sample Requirements
- Sample Collection: Daily by 6 PM
- Report Timing: Block samples: 5 days | Tissue biopsy: 5 days | Complex tissue: 7 days
- Sample Type: Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block
- Shipping: Ship at room temperature with required documentation
Nationwide Testing Availability
GGC DNA maintains testing facilities across the United States, with convenient locations in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network ensures accessible, high-quality EGFR testing for patients nationwide.
Required Documentation
For accurate testing and interpretation, please provide:
- Complete Histopathology report
- Detailed site of biopsy information
- Comprehensive clinical history
- Relevant imaging studies when available
Take Control of Your Cancer Treatment Today
Don’t leave your treatment decisions to chance. The Immunohistochemistry EGFR Test provides the critical biomarker information needed to develop the most effective, personalized cancer treatment strategy. Our experienced team of oncologists and pathologists are ready to help you navigate your cancer journey with confidence.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your EGFR test and take the first step toward targeted, effective cancer treatment.
Early biomarker testing can make a significant difference in treatment outcomes. Contact us now to discuss how EGFR testing can benefit your specific situation and help guide your oncologist in developing the most appropriate treatment plan for your unique cancer profile.
