Immunohistochemistry DOG1 Test: Advanced GIST Detection
Understanding the DOG1 Test for Gastrointestinal Stromal Tumors
The Immunohistochemistry DOG1 Test represents a breakthrough in cancer diagnostics, specifically designed to identify gastrointestinal stromal tumors (GIST) with exceptional accuracy. This sophisticated laboratory technique detects the presence of DOG1 (Discovered on GIST-1) protein, a highly specific biomarker that distinguishes GIST from other gastrointestinal tumors. As a leading diagnostic tool in modern oncology, the DOG1 test has revolutionized how pathologists and oncologists approach tumor classification and treatment planning.
What Does the DOG1 Test Measure?
The Immunohistochemistry DOG1 Test precisely measures the expression of DOG1 protein in tumor tissue samples. This transmembrane protein is expressed in approximately 95% of GIST cases, making it one of the most reliable markers for this specific cancer type. The test works by applying specialized antibodies that bind specifically to DOG1 proteins, creating visible staining patterns that pathologists can analyze under a microscope. This process provides definitive evidence of GIST presence, even in cases where other diagnostic methods yield ambiguous results.
- Detects DOG1 protein expression in tumor tissue
- Identifies gastrointestinal stromal tumors with high specificity
- Differentiates GIST from other spindle cell tumors
- Provides critical information for targeted therapy selection
Who Should Consider the DOG1 Test?
The Immunohistochemistry DOG1 Test is recommended for patients presenting with specific clinical scenarios that suggest possible gastrointestinal stromal tumors. Early and accurate diagnosis is crucial for effective treatment and improved outcomes.
Clinical Indications and Symptoms
- Patients with unexplained abdominal pain or discomfort
- Individuals with gastrointestinal bleeding of unknown origin
- Those with abdominal masses detected during physical examination
- Patients with suspicious findings on CT scans, MRI, or endoscopy
- Individuals with family history of GIST or related syndromes
- Patients requiring confirmation of GIST diagnosis for treatment planning
Benefits of the DOG1 Immunohistochemistry Test
Choosing the Immunohistochemistry DOG1 Test provides numerous advantages for both patients and healthcare providers, ensuring comprehensive diagnostic accuracy and informed treatment decisions.
Key Advantages
- High Diagnostic Accuracy: DOG1 demonstrates superior sensitivity and specificity compared to traditional markers
- Targeted Treatment Guidance: Confirmed GIST diagnosis enables appropriate tyrosine kinase inhibitor therapy
- Prognostic Information: Test results help assess tumor behavior and potential aggressiveness
- Minimized Misdiagnosis: Reduces the risk of confusing GIST with other gastrointestinal tumors
- Personalized Care: Facilitates customized treatment plans based on precise tumor characterization
Understanding Your DOG1 Test Results
Interpreting Immunohistochemistry DOG1 Test results requires professional medical expertise, but understanding the basic principles can help patients engage more effectively in their care.
Result Interpretation Guidelines
- Positive Result: Strong DOG1 staining indicates high probability of GIST, requiring immediate consultation with an oncologist
- Negative Result: Absence of DOG1 staining suggests alternative diagnoses, though rare DOG1-negative GIST cases exist
- Focal Staining: Patchy or weak staining may require additional testing or clinical correlation
- Combined Analysis: Results are typically interpreted alongside CD117 (c-KIT) testing for comprehensive assessment
Your healthcare provider will explain the specific implications of your test results and recommend appropriate next steps based on the findings and your overall clinical picture.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Immunohistochemistry DOG1 Test | $76 USD | $112 USD |
Turnaround Time and Sample Requirements
- Sample Collection: Daily by 6 PM
- Report Timeline: Tissue Block: 5 days | Tissue Biopsy: 5 days | Complex Tissue: 7 days
- Sample Type: Submit tumor tissue in 10% formal-saline OR formalin-fixed paraffin-embedded block
- Shipping: Ship at room temperature with proper documentation
Nationwide Availability and Booking
General Genetics Corporation provides comprehensive diagnostic services across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art laboratories ensure consistent, high-quality results regardless of your location.
Ready to Schedule Your Test?
Take control of your health with the precise diagnostic capabilities of the Immunohistochemistry DOG1 Test. Our experienced team is ready to assist you with scheduling, sample collection guidance, and result interpretation. Contact us today to book your test and take the first step toward accurate diagnosis and effective treatment.
Call or WhatsApp: +1(267) 388-9828
Don’t delay critical diagnostic testing. Early and accurate detection of gastrointestinal stromal tumors can significantly impact treatment success and long-term outcomes. Trust General Genetics Corporation for reliable, advanced cancer diagnostics backed by scientific excellence and patient-centered care.
