IGLL1 Gene Agammaglobulinemia Type 2 Autosomal Recessive NGS Genetic DNA Test
Comprehensive Genetic Analysis for Immune System Disorders
The IGLL1 Gene Agammaglobulinemia Type 2 Autosomal Recessive NGS Genetic DNA Test represents a breakthrough in molecular diagnostics for primary immunodeficiency disorders. This advanced genetic screening utilizes state-of-the-art Next-Generation Sequencing technology to identify mutations in the IGLL1 gene, which plays a critical role in B-cell development and antibody production. Agammaglobulinemia type 2 is a rare autosomal recessive condition characterized by the near absence of B cells and immunoglobulins, leaving affected individuals highly susceptible to recurrent bacterial infections.
What This Test Measures and Detects
Our comprehensive NGS-based analysis specifically targets the IGLL1 gene to identify pathogenic variants responsible for agammaglobulinemia type 2. The test examines:
- Point mutations, insertions, and deletions in the IGLL1 gene coding regions
- Autosomal recessive inheritance patterns requiring mutations in both gene copies
- Variants affecting the immunoglobulin lambda-like polypeptide 1 protein function
- Genetic alterations disrupting pre-B cell receptor signaling and B-cell maturation
- Pathogenic variants that impair antibody production and immune response
Who Should Consider This Genetic Test
This specialized genetic analysis is recommended for individuals presenting with:
- Recurrent bacterial infections beginning in infancy or early childhood
- Severely reduced or absent serum immunoglobulins (IgG, IgA, IgM)
- Family history of primary immunodeficiency disorders
- Unexplained failure to thrive or developmental delays
- Persistent respiratory infections, sinusitis, or otitis media
- Autoimmune manifestations or chronic gastrointestinal issues
- Consanguineous parentage increasing autosomal recessive disorder risk
Clinical Benefits of Genetic Testing
Undergoing the IGLL1 gene analysis provides numerous clinical advantages:
- Accurate Diagnosis: Confirms agammaglobulinemia type 2 with molecular precision
- Personalized Treatment: Guides immunoglobulin replacement therapy decisions
- Family Planning: Enables informed reproductive choices and genetic counseling
- Early Intervention: Facilitates prompt treatment initiation to prevent complications
- Prognostic Information: Helps predict disease course and management requirements
- Differential Diagnosis: Distinguishes from other immunodeficiency disorders
Understanding Your Test Results
Our comprehensive genetic report provides clear interpretation of your results:
- Positive Result: Identifies pathogenic mutations in both IGLL1 gene copies, confirming agammaglobulinemia type 2 diagnosis
- Carrier Status: Detects single mutation carriers who may pass the condition to offspring
- Negative Result: No pathogenic variants found, suggesting alternative diagnoses
- Variant of Uncertain Significance: Identifies genetic changes requiring further clinical correlation
All results include detailed explanations and recommendations for follow-up care with hematologists and immunology specialists.
Test Specifications and Pricing
| Test Component | Details |
|---|---|
| Test Name | IGLL1 Gene Agammaglobulinemia Type 2 Autosomal Recessive NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
| Specialty | Hematology and Genetics |
Pre-Test Requirements
Before scheduling your genetic test, we recommend:
- Complete clinical history documentation of the patient
- Genetic counseling session to create detailed family pedigree
- Discussion of testing implications and potential outcomes
- Review of insurance coverage and financial considerations
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, San Francisco, and many more. Our network of certified collection centers ensures accessible genetic testing services nationwide.
Take Control of Your Genetic Health
Don’t let uncertainty about immune system disorders affect your quality of life. Our IGLL1 Gene Agammaglobulinemia Type 2 NGS Genetic DNA Test provides the definitive answers you need for proper diagnosis and treatment planning. With our discounted price of $500 USD (regularly $700 USD), advanced genetic testing is more accessible than ever.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic consultation and testing appointment. Our genetic specialists are ready to guide you through the testing process and help you understand your results.
Early genetic diagnosis can significantly improve treatment outcomes and quality of life for individuals with agammaglobulinemia type 2. Take the first step toward comprehensive immune system evaluation and personalized care management.
