HOXB13 Gene Prostate Cancer Familial Association NGS Genetic DNA Test
Understanding Hereditary Prostate Cancer Risk
The HOXB13 Gene Prostate Cancer Familial Association NGS Genetic DNA Test represents a breakthrough in personalized cancer risk assessment. This advanced genetic screening specifically targets the HOXB13 gene, which plays a critical role in prostate development and has been strongly linked to hereditary prostate cancer susceptibility. By identifying individuals with inherited HOXB13 mutations, this test enables proactive healthcare decisions and personalized screening strategies that can significantly impact prostate cancer outcomes.
What Does the HOXB13 Test Measure?
This comprehensive genetic analysis utilizes Next-Generation Sequencing (NGS) technology to examine the HOXB13 gene for specific mutations known to increase prostate cancer risk. The test detects:
- G84E mutation and other pathogenic variants in the HOXB13 gene
- Inherited genetic alterations associated with familial prostate cancer
- Specific nucleotide changes that disrupt normal prostate cell function
- Genetic markers indicating increased lifetime prostate cancer risk
Who Should Consider HOXB13 Genetic Testing?
This test is particularly valuable for individuals with specific risk factors for hereditary prostate cancer:
- Men with a strong family history of prostate cancer
- Individuals with multiple first-degree relatives diagnosed with prostate cancer
- Those with early-onset prostate cancer (diagnosed before age 55)
- Men of African descent with family history of prostate cancer
- Individuals with family members carrying known HOXB13 mutations
- Those with aggressive or metastatic prostate cancer in family history
Clinical Benefits of HOXB13 Testing
Understanding your HOXB13 genetic status provides numerous clinical advantages:
- Personalized Screening Protocols: Tailor prostate cancer screening frequency and methods based on genetic risk
- Early Detection Strategies: Implement enhanced monitoring for high-risk individuals
- Family Risk Assessment: Identify at-risk relatives who may benefit from genetic counseling
- Informed Treatment Decisions: Guide prostate cancer management approaches when diagnosed
- Proactive Health Planning: Develop comprehensive prevention and monitoring strategies
Understanding Your Test Results
Your HOXB13 genetic test results will fall into one of several categories, each with specific implications:
Positive Result
A positive result indicates the presence of a pathogenic HOXB13 mutation. This suggests an increased lifetime risk of developing prostate cancer, typically estimated at 20-60% higher than the general population. Individuals with positive results should:
- Begin prostate cancer screening at age 40 or earlier
- Consider more frequent PSA testing and digital rectal exams
- Discuss enhanced screening options with their healthcare provider
- Inform at-risk family members about genetic counseling options
Negative Result
A negative result means no known pathogenic HOXB13 mutations were detected. However, this does not eliminate prostate cancer risk entirely, as other genetic and environmental factors contribute to overall risk. Standard screening recommendations should still be followed.
Variant of Uncertain Significance (VUS)
Some results may identify genetic changes with unknown clinical significance. These variants require ongoing research and should be interpreted with caution in consultation with a genetic counselor.
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | HOXB13 Gene Prostate Cancer Familial Association NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) |
Pre-Test Requirements
Before undergoing HOXB13 genetic testing, we recommend:
- Complete clinical history documentation
- Genetic counseling session to discuss implications
- Development of family pedigree chart
- Understanding of potential psychological impacts
- Discussion of insurance and privacy considerations
Nationwide Accessibility
GGC DNA maintains testing facilities across the United States, ensuring convenient access to advanced genetic testing services. Our network includes locations in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Each facility maintains the highest standards of laboratory excellence and patient care.
Take Control of Your Prostate Health
Understanding your genetic predisposition to prostate cancer empowers you to make informed healthcare decisions. The HOXB13 Gene Prostate Cancer Familial Association NGS Genetic DNA Test provides valuable insights that can guide personalized screening and prevention strategies. With results available in just 3-4 weeks and multiple sample collection options, accessing this important genetic information has never been more convenient.
Book Your Genetic Cancer Risk Assessment Today
Ready to take the next step in understanding your prostate cancer risk? Our genetic specialists are available to discuss the HOXB13 test and help you determine if genetic testing is right for you. Contact us today to schedule your appointment or learn more about our comprehensive genetic testing services.
Call or WhatsApp: +1(267) 388-9828
Our team is standing by to answer your questions, provide detailed information about the testing process, and help you schedule your HOXB13 genetic test at one of our convenient nationwide locations.
