HLA DNA High Resolution Typing DRB1 Locus Test
Comprehensive Introduction to HLA Typing
The HLA DNA High Resolution Typing DRB1 Locus Test represents a cutting-edge genetic analysis that plays a pivotal role in modern transplantation medicine. This sophisticated diagnostic tool examines the DRB1 gene within the Human Leukocyte Antigen (HLA) system, which serves as the body’s primary mechanism for distinguishing between self and non-self cells. The HLA system’s critical function in immune recognition makes this test indispensable for ensuring successful organ and tissue transplantation outcomes.
High-resolution typing provides unprecedented genetic detail, allowing healthcare providers to identify the most compatible donor-recipient matches with remarkable precision. This level of genetic characterization has revolutionized transplant medicine by significantly reducing complications and improving long-term success rates for patients undergoing life-saving procedures.
What the Test Measures and Detects
The HLA DNA High Resolution Typing DRB1 Locus Test specifically analyzes the DRB1 gene, which encodes a crucial component of the HLA class II molecules. These molecules are primarily expressed on antigen-presenting cells and play a fundamental role in initiating immune responses. The test provides detailed information about:
- Specific DRB1 allele variations at the DNA level
- Genetic compatibility between potential donors and recipients
- Risk assessment for transplant rejection
- Susceptibility to certain autoimmune conditions
- Genetic markers associated with graft-versus-host disease
Using advanced Polymerase Chain Reaction (PCR) and sequencing technologies, this test achieves resolution down to the allele level, providing the most accurate genetic matching information available in clinical practice.
Who Should Consider This Test
This specialized genetic test is recommended for individuals in specific medical situations:
Transplant Candidates and Donors
- Patients awaiting organ transplantation (kidney, liver, heart, lung)
- Bone marrow or stem cell transplant recipients
- Potential living donors for family members
- Unrelated donor registry participants
Autoimmune and Inflammatory Conditions
- Patients with suspected HLA-associated autoimmune diseases
- Individuals with family history of specific autoimmune disorders
- Cases where HLA typing may aid in differential diagnosis
Reproductive Medicine
- Couples with recurrent pregnancy loss
- Families with known HLA-associated genetic conditions
Significant Benefits of HLA DRB1 Testing
Undergoing HLA DNA High Resolution Typing provides numerous advantages for patients and healthcare providers:
- Enhanced Transplant Success: Identifies optimal donor matches to minimize rejection risks
- Reduced Complications: Lowers incidence of graft-versus-host disease in bone marrow transplants
- Personalized Medicine: Enables tailored immunosuppression regimens based on genetic compatibility
- Early Risk Assessment: Identifies potential autoimmune disease susceptibility
- Family Planning Guidance: Provides valuable information for genetic counseling
- Improved Long-term Outcomes: Contributes to better organ survival and patient quality of life
Understanding Your Test Results
Your HLA DNA High Resolution Typing results will provide detailed genetic information that requires professional interpretation:
Result Interpretation
- DRB1 Allele Designations: Results are reported as specific DRB1 alleles (e.g., DRB1*01:01, DRB1*15:01)
- Match Quality: For transplantation, results indicate the degree of compatibility between donor and recipient
- Risk Assessment: Certain alleles may indicate increased susceptibility to specific autoimmune conditions
Clinical Implications
- Transplant Planning: High-resolution matches significantly improve transplant success rates
- Treatment Decisions: Results may influence immunosuppression strategies
- Genetic Counseling: Provides basis for family genetic risk discussions
It’s essential to discuss your results with a qualified hematologist or transplant specialist who can provide personalized interpretation and recommendations based on your specific medical situation.
Test Information and Pricing
| Test Parameter | Details |
|---|---|
| Test Name | HLA DNA High Resolution Typing DRB1 Locus Test |
| Discount Price | $200 USD |
| Regular Price | $300 USD |
| Turnaround Time | 10-12 days |
| Sample Type | 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube OR Buccal swab collected in a sterile container |
| Shipping Instructions | Ship refrigerated. DO NOT FREEZE |
| Preparation | No special preparation required |
| Testing Method | PCR, Sequencing |
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas. Our network includes specialized collection centers in:
- New York City and surrounding areas
- Los Angeles and Southern California
- Chicago and the Midwest region
- Houston and Texas medical centers
- Phoenix and Southwest locations
- All other major US cities and regions
Our comprehensive national presence ensures that patients can access this critical genetic testing regardless of their location, with consistent quality standards and professional service at every facility.
Take the Next Step Toward Better Health
Don’t leave your transplant success or genetic health assessment to chance. The HLA DNA High Resolution Typing DRB1 Locus Test provides the precise genetic information needed for informed medical decisions and optimal treatment outcomes.
Ready to schedule your test? Contact our dedicated patient services team today to book your appointment or discuss any questions you may have about this important genetic analysis.
Call or WhatsApp: +1(267) 388-9828
Our knowledgeable staff is available to assist with scheduling, insurance inquiries, and providing additional information about the testing process. Take control of your health journey with the most advanced HLA typing technology available.
