HLA ABC Class 1 Typing Test
Comprehensive Introduction to HLA ABC Class 1 Typing
The HLA ABC Class 1 Typing Test represents a cornerstone in modern transplantation medicine, providing critical genetic information necessary for successful organ and tissue transplantation. Human Leukocyte Antigens (HLA) are protein markers found on the surface of most cells in your body, serving as the immune system’s identification system. The Class 1 HLA antigens (HLA-A, HLA-B, and HLA-C) play a vital role in immune recognition and are essential for determining compatibility between donors and recipients in transplantation procedures.
This sophisticated genetic analysis is particularly crucial because mismatched HLA antigens can trigger severe immune responses, leading to organ rejection and transplant failure. By precisely identifying these genetic markers, healthcare providers can select the most compatible donor-recipient pairs, significantly improving transplantation outcomes and patient survival rates.
What the HLA ABC Class 1 Typing Test Measures
The HLA ABC Class 1 Typing Test specifically detects and identifies:
- HLA-A Antigens: Critical for immune system recognition and viral defense mechanisms
- HLA-B Antigens: Essential for transplantation compatibility and autoimmune disease associations
- HLA-C Antigens: Important for natural killer cell regulation and immune response modulation
Using advanced Reverse Sequence Specific Oligonucleotide Probe (SSOP) technology with Luminex platform, this test provides high-resolution typing that ensures accurate antigen identification. The methodology offers superior sensitivity and specificity compared to traditional serological methods, enabling more precise matching and better clinical outcomes.
Who Should Consider HLA ABC Class 1 Typing
This test is essential for individuals in the following circumstances:
- Organ Transplant Candidates: Patients awaiting kidney, liver, heart, lung, or pancreas transplantation
- Bone Marrow Transplant Recipients: Individuals requiring hematopoietic stem cell transplantation
- Living Donor Evaluation: Potential donors being assessed for organ donation compatibility
- Family Members of Transplant Candidates: Relatives being evaluated as potential living donors
- Patients with Autoimmune Conditions: Individuals with HLA-associated autoimmune disorders requiring monitoring
- Pre-transplant Workup: Comprehensive evaluation before major transplantation procedures
Specialty Referrals
This test is commonly ordered by:
- Nephrologists for kidney transplantation
- Hematologists for bone marrow transplantation
- Gastroenterologists for liver transplantation
- Transplant Surgeons for various organ transplant procedures
Significant Benefits of HLA ABC Class 1 Typing
Undergoing HLA ABC Class 1 Typing provides numerous clinical advantages:
- Enhanced Transplant Success: Significantly reduces the risk of organ rejection through precise matching
- Improved Patient Survival: Better HLA matching correlates with longer graft survival and reduced complications
- Personalized Immunosuppression: Enables tailored immunosuppressive therapy based on specific HLA profiles
- Reduced Healthcare Costs: Minimizes expenses associated with rejection treatment and re-transplantation
- Comprehensive Donor Evaluation: Facilitates optimal donor selection from available pools
- Future Medical Planning: Provides valuable genetic information for potential future medical needs
Understanding Your HLA Typing Results
Your HLA ABC Class 1 Typing results will provide detailed information about your specific antigen profile:
Interpretation Guidelines
- Complete Match: Ideal scenario where donor and recipient share identical HLA antigens
- Partial Match: Some antigens match while others differ, requiring careful clinical management
- Mismatch: Significant antigen differences that may increase rejection risk
- Rare Antigens: Identification of uncommon HLA types that may affect donor availability
Your healthcare provider will explain the clinical significance of your specific HLA profile and how it impacts your transplantation options. The results become part of your permanent medical record and are used for national donor registry matching when applicable.
Test Information and Pricing
| Test Parameter | Details |
|---|---|
| Test Name | HLA ABC Class 1 Typing Test |
| Discount Price | $302 USD |
| Regular Price | $334 USD |
| Turnaround Time | 10-12 Days |
| Sample Type | 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube |
| Shipping Requirements | Ship refrigerated. DO NOT FREEZE |
| Required Documentation | Doctor’s prescription on letterhead with 1 photograph each of recipient and donor duly stamped AND Consent form for HLA Typing for Solid organ transplant (Form 33) |
Nationwide Accessibility
We maintain comprehensive testing facilities across the United States, ensuring convenient access to HLA ABC Class 1 Typing services in all major metropolitan areas including:
- New York City and surrounding regions
- Los Angeles and Southern California
- Chicago and Midwest locations
- Houston and Texas facilities
- Phoenix and Southwest centers
- Philadelphia and Northeast locations
- Miami and Florida centers
Our network of certified laboratories maintains consistent quality standards and follows rigorous accreditation protocols to ensure reliable, accurate results for every patient.
Take the Next Step Toward Transplantation Success
Don’t leave your transplantation outcomes to chance. The HLA ABC Class 1 Typing Test provides the critical genetic information needed to maximize your transplant success and minimize complications. Our experienced genetic counselors and transplantation specialists are available to answer your questions and guide you through the testing process.
Ready to schedule your HLA ABC Class 1 Typing Test? Contact our transplantation coordination team today to book your appointment and take the first step toward successful transplantation matching.
Call or WhatsApp: +1(267) 388-9828
Our dedicated transplantation specialists are available to discuss your specific needs, explain the testing process in detail, and help coordinate all necessary documentation. Don’t delay this critical step in your transplantation journey – secure your HLA typing today and move forward with confidence in your medical care.
