HLA AB Class 1 Typing Test – Comprehensive Tissue Compatibility Analysis
Understanding HLA AB Class 1 Typing
The HLA AB Class 1 Typing Test represents a cornerstone in modern transplantation medicine, providing essential genetic information for successful organ and tissue transplantation. Human Leukocyte Antigens (HLA) are proteins found on the surface of most cells in your body that play a critical role in immune system recognition. The Class 1 HLA antigens, specifically HLA-A and HLA-B, are fundamental markers that determine tissue compatibility between donors and recipients.
Scientific Foundation and Clinical Importance
HLA typing has revolutionized transplantation medicine by enabling precise matching between donors and recipients. The HLA AB Class 1 antigens are inherited from both parents and create a unique “genetic fingerprint” that the immune system uses to distinguish between self and non-self tissues. When these markers don’t match adequately between donor and recipient, the recipient’s immune system may recognize the transplanted organ as foreign and mount an attack, leading to transplant rejection.
What the HLA AB Class 1 Typing Test Measures
This sophisticated genetic analysis specifically detects and identifies:
- HLA-A Antigens: Critical markers present on virtually all nucleated cells
- HLA-B Antigens: Essential surface proteins that trigger immune responses
- Tissue Compatibility: Degree of matching between donor and recipient HLA profiles
- Immunological Risk Assessment: Potential for graft rejection or graft-versus-host disease
Advanced Testing Methodology
Our laboratory utilizes the cutting-edge Reverse Sequence Specific Oligonucleotide Probe (Reverse SSOP) methodology with Luminex technology. This highly sensitive and specific approach allows for comprehensive HLA typing with exceptional accuracy, providing transplant teams with reliable data for critical medical decisions.
Who Should Consider HLA AB Class 1 Typing
This test is essential for individuals in the following circumstances:
- Organ Transplant Candidates: Patients awaiting kidney, liver, heart, lung, or pancreas transplantation
- Bone Marrow Transplant Recipients: Individuals requiring hematopoietic stem cell transplantation
- Living Donor Evaluation: Potential donors being assessed for organ donation
- Family Member Screening: Relatives being evaluated as potential living donors
- Transplant Follow-up: Patients requiring post-transplant monitoring
Medical Specialties Involved
This test is commonly ordered by:
- Nephrologists for kidney transplantation
- Hematologists for bone marrow transplants
- Gastroenterologists for liver transplantation
- Transplant Surgeons for various organ transplants
Benefits of HLA AB Class 1 Typing
Undergoing HLA AB Class 1 Typing provides numerous critical advantages:
- Improved Transplant Success: Better matching leads to higher graft survival rates
- Reduced Rejection Risk: Minimizes the likelihood of acute and chronic rejection
- Personalized Immunosuppression: Enables tailored medication regimens
- Enhanced Donor Selection: Facilitates optimal donor-recipient matching
- Comprehensive Risk Assessment: Provides valuable prognostic information
- Long-term Health Outcomes: Contributes to better post-transplant quality of life
Understanding Your Test Results
Your HLA AB Class 1 Typing results will provide detailed information about your specific HLA antigens. Here’s what to understand:
Interpretation Guidelines
- High Match Percentage: Indicates strong compatibility with potential donors
- Partial Match: Some antigens match while others differ
- Mismatch Identified: Significant differences that may require specialized management
- Haplotype Analysis: Inherited patterns that help identify suitable family donors
Clinical Implications
Your transplant team will use these results to:
- Determine the best possible donor match
- Calculate the likelihood of successful transplantation
- Develop personalized immunosuppression strategies
- Assess long-term prognosis and monitoring needs
Test Pricing and Requirements
| Test Component | Price (USD) |
|---|---|
| Discount Price | $216 |
| Regular Price | $240 |
Essential Requirements
- Turnaround Time: 10-12 days
- Sample Type: 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube
- Shipping Instructions: Ship refrigerated. DO NOT FREEZE
- Mandatory Documentation: Doctor’s prescription on letterhead with 1 photograph each of recipient and donor duly stamped AND Consent form for HLA Typing for Solid organ transplant (Form 33)
Nationwide Accessibility
We have diagnostic centers conveniently located throughout the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures that quality HLA typing services are accessible to patients nationwide.
Take the Next Step Toward Transplantation Success
Don’t leave your transplant success to chance. The HLA AB Class 1 Typing Test provides the critical genetic information needed for optimal donor matching and improved transplantation outcomes. Our experienced team and state-of-the-art laboratory facilities ensure accurate, reliable results that transplant specialists trust.
Ready to schedule your HLA AB Class 1 Typing Test? Contact us today at +1(267) 388-9828 to book your appointment or speak with our genetic counseling specialists. We’re here to support you through every step of your transplantation journey with precision, care, and expertise.
