Hereditary Persistence of Fetal Hemoglobin (HPFH) Test
Understanding Hereditary Persistence of Fetal Hemoglobin
Hereditary Persistence of Fetal Hemoglobin (HPFH) represents a unique genetic condition where fetal hemoglobin production continues into adulthood rather than switching to adult hemoglobin after birth. This remarkable genetic trait occurs due to specific mutations in the beta-globin gene cluster that prevent the normal developmental switch from fetal to adult hemoglobin. While typically asymptomatic, HPFH holds significant clinical importance as it can provide natural protection against severe hemoglobin disorders like sickle cell disease and beta-thalassemia when inherited alongside these conditions.
What the HPFH Test Measures and Detects
Our advanced HPFH screening utilizes cutting-edge End Point PCR technology to identify specific genetic mutations responsible for continued fetal hemoglobin production. The test comprehensively analyzes:
- Genetic mutations in the beta-globin gene cluster
- Deletional and non-deletional HPFH variants
- Specific promoter region abnormalities
- Hemoglobin switching regulatory elements
- Associated genetic markers for hemoglobin disorders
Sample Requirements and Processing
The test requires specific sample types for accurate analysis:
- Amniotic fluid for prenatal diagnosis
- Chorionic villi sampling for early pregnancy screening
- Cord blood for newborn assessment
- Standard blood samples for adult testing
Who Should Consider HPFH Testing
Several groups benefit significantly from HPFH genetic screening:
- Individuals with family history of hemoglobin disorders
- Couples planning pregnancy with known sickle cell or thalassemia risk
- Patients with unexplained elevated fetal hemoglobin levels
- Those with mild anemia without clear diagnosis
- Individuals from ethnic backgrounds with high hemoglobinopathy prevalence
- Genetic counseling candidates for family planning
Clinical Indications and Symptoms
While HPFH itself is typically asymptomatic, testing is recommended when:
- Routine blood tests show elevated hemoglobin F levels
- Family members have diagnosed hemoglobin disorders
- Planning pregnancy in high-risk populations
- Unexplained hematological abnormalities present
- Genetic counseling for inherited blood disorders needed
Benefits of HPFH Genetic Testing
Comprehensive HPFH screening offers numerous advantages:
- Early Risk Assessment: Identify genetic predisposition to hemoglobin disorders
- Reproductive Planning: Make informed decisions about family planning
- Therapeutic Insights: Understand potential protective effects against sickle cell disease
- Personalized Care: Develop targeted healthcare strategies based on genetic profile
- Family Screening: Identify at-risk relatives for preventive care
- Research Contribution: Advance understanding of hemoglobin genetics
Understanding Your HPFH Test Results
Our comprehensive results interpretation includes:
- Positive HPFH Detection: Indicates presence of genetic mutations causing continued fetal hemoglobin production
- Negative Result: Normal hemoglobin switching pattern without HPFH mutations
- Variant Classification: Detailed analysis of specific HPFH type and genetic implications
- Clinical Correlation: How results relate to potential hemoglobin disorder protection
- Genetic Counseling Recommendations: Guidance for family planning and management
Result Interpretation Framework
Our expert geneticists provide clear, actionable insights:
- Detailed explanation of genetic findings
- Potential health implications and benefits
- Reproductive risk assessment
- Follow-up testing recommendations if needed
- Lifestyle and healthcare management suggestions
HPFH Test Pricing and Details
| Test Component | Details | Price (USD) |
|---|---|---|
| Test Name | Hereditary Persistence of Fetal Hemoglobin (HPFH) | – |
| Discount Price | Special promotional rate | $150 |
| Regular Price | Standard testing fee | $200 |
| Turnaround Time | Comprehensive analysis period | 7-8 days |
| Testing Method | Advanced genetic analysis | End Point PCR |
Important Pre-Test Information
Please note the following requirements:
- HPFH testing requires a Doctor’s prescription for standard cases
- Prescription not applicable for surgical, pregnancy, or international travel cases
- Consult with our genetic counselors for specific testing indications
- Insurance coverage verification recommended before testing
Nationwide Testing Availability
We proudly serve patients across the United States with comprehensive genetic testing services. Our state-of-the-art facilities are conveniently located in all major metropolitan areas including:
- New York City and surrounding regions
- Los Angeles and Southern California
- Chicago and Midwest locations
- Houston and Texas medical centers
- Phoenix and Southwest facilities
- All other major US cities and regions
Schedule Your HPFH Test Today
Take the first step toward understanding your genetic health. Our expert team is ready to provide comprehensive HPFH testing with professional interpretation and personalized guidance.
Call or WhatsApp us now to book your appointment:
Phone: +1(267) 388-9828
Our genetic specialists are available to answer your questions, discuss testing options, and help you understand how HPFH screening can benefit your health management strategy. Don’t wait to gain valuable insights into your genetic profile – contact us today for professional, confidential genetic testing services.
