Ham Test Paroxysmal Nocturnal Hemoglobinuria PNH Screening Test
Understanding Paroxysmal Nocturnal Hemoglobinuria (PNH)
Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare, acquired hematopoietic stem cell disorder characterized by the abnormal breakdown of red blood cells (hemolysis), blood clot formation (thrombosis), and bone marrow failure. The Ham Test serves as a crucial diagnostic tool in identifying this condition, which affects approximately 1-2 people per million worldwide. Early detection through specialized screening like the Ham Test can significantly improve patient outcomes and quality of life.
What Does the Ham Test Detect?
The Ham Test specifically measures the susceptibility of red blood cells to complement-mediated hemolysis. In PNH, blood cells lack specific protective proteins (CD55 and CD59) due to a genetic mutation in the PIG-A gene. This deficiency makes the cells vulnerable to destruction by the body’s complement system. The test evaluates:
- Complement-mediated red blood cell lysis
- Presence of PNH clone cells in circulation
- Degree of hemolytic activity in acidified serum
- Confirmation of PNH diagnosis through specific cellular responses
Advanced Gel Technique Methodology
Our Ham Test utilizes the sophisticated Gel Technique, which provides superior sensitivity and specificity compared to traditional methods. This advanced approach ensures accurate detection of even small PNH clones, enabling early diagnosis and intervention.
Who Should Consider the Ham Test?
This screening test is recommended for individuals experiencing symptoms suggestive of PNH or related hematological conditions:
- Unexplained hemolytic anemia with negative direct antiglobulin test
- Recurrent episodes of dark-colored urine, especially in the morning
- Unexplained thrombosis in unusual locations
- Bone marrow failure syndromes
- Patients with aplastic anemia
- Individuals with unexplained fatigue and weakness
- Those with abdominal pain and difficulty swallowing
- Patients with elevated lactate dehydrogenase (LDH) levels
Benefits of Early PNH Detection
Timely diagnosis through the Ham Test offers numerous advantages:
- Early Intervention: Enables prompt treatment to prevent complications
- Disease Monitoring: Helps track disease progression and treatment response
- Risk Assessment: Identifies patients at high risk for thrombosis
- Treatment Planning: Guides appropriate therapeutic decisions
- Improved Outcomes: Reduces morbidity and mortality through timely management
- Quality of Life: Helps manage symptoms and improve daily functioning
Understanding Your Test Results
Interpreting Ham Test results requires professional medical expertise, but here’s general guidance:
Positive Result
A positive Ham Test indicates the presence of PNH cells and confirms the diagnosis of Paroxysmal Nocturnal Hemoglobinuria. Your hematologist will discuss:
- Treatment options including complement inhibitors
- Monitoring strategies for disease progression
- Management of associated complications
- Long-term follow-up requirements
Negative Result
A negative result typically rules out PNH as the cause of your symptoms. However, your physician may recommend:
- Further testing for other hematological conditions
- Continued monitoring if symptoms persist
- Evaluation for alternative diagnoses
Borderline or Equivocal Results
In some cases, results may be inconclusive, requiring:
- Repeat testing
- Additional specialized testing
- Flow cytometry for confirmation
- Close clinical correlation
Test Details and Pricing
| Test Component | Price (USD) |
|---|---|
| Ham Test PNH Screening – Discount Price | $36 |
| Ham Test PNH Screening – Regular Price | $40 |
Test Specifications
- Turnaround Time: Sample collected daily by 9 AM; Report available same day
- Sample Type: 3 mL (2 mL minimum) whole blood from 1 Lavender Top (EDTA) tube
- Shipping Instructions: Ship refrigerated. DO NOT FREEZE
- Preparation: No special preparation required
- Methodology: Gel Technique
- Specialty: Hematology/Immunopathology
Nationwide Accessibility
We proudly serve patients across the United States with convenient locations in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our extensive network ensures that quality hematological testing is accessible to everyone, regardless of location.
Take Control of Your Health Today
Don’t let unexplained symptoms compromise your quality of life. The Ham Test provides definitive answers about potential PNH, enabling you and your healthcare provider to make informed decisions about your care. Our experienced hematology specialists and state-of-the-art laboratory facilities ensure accurate, reliable results you can trust.
Ready to schedule your Ham Test? Contact us today at +1(267) 388-9828 to book your appointment or speak with our knowledgeable staff. We’re here to answer your questions and help you take the next step toward better health.
Early detection saves lives. Book your PNH screening test now and gain peace of mind about your hematological health.
