FOXO1 Break Apart FISH Alveolar Rhabdomyosarcoma Diagnostic
Comprehensive Introduction to FOXO1 Break Apart FISH Testing
The FOXO1 Break Apart FISH Alveolar Rhabdomyosarcoma Diagnostic represents a cutting-edge molecular diagnostic approach specifically designed to detect chromosomal rearrangements involving the FOXO1 gene, which are hallmark genetic alterations in alveolar rhabdomyosarcoma. This sophisticated testing methodology provides clinicians with definitive diagnostic information that is essential for accurate tumor classification and personalized treatment planning. As one of the most specific diagnostic tools available for soft tissue sarcoma characterization, this test plays a critical role in modern oncology practice by enabling precise genetic profiling of tumor samples.
What the FOXO1 Break Apart FISH Test Measures and Detects
This specialized diagnostic test utilizes Fluorescence In Situ Hybridization (FISH) technology to identify specific chromosomal rearrangements involving the FOXO1 gene on chromosome 13. The test specifically detects:
- PAX3-FOXO1 fusion genes resulting from t(2;13) chromosomal translocations
- PAX7-FOXO1 fusion genes resulting from t(1;13) chromosomal translocations
- Other FOXO1 gene rearrangements that characterize alveolar rhabdomyosarcoma
- Chromosomal breakpoints within the FOXO1 gene region
These genetic abnormalities are pathognomonic for alveolar rhabdomyosarcoma and provide definitive diagnostic evidence that distinguishes this aggressive tumor type from other soft tissue sarcomas.
Who Should Consider FOXO1 Break Apart FISH Testing
Clinical Indications and Symptoms
This diagnostic test is recommended for patients presenting with:
- Suspected rhabdomyosarcoma based on clinical presentation and imaging findings
- Soft tissue masses with histological features suggestive of alveolar rhabdomyosarcoma
- Pediatric or adolescent patients with rapidly growing soft tissue tumors
- Patients requiring definitive classification of rhabdomyosarcoma subtypes
- Cases where treatment planning depends on accurate genetic characterization
- Patients with recurrent or metastatic soft tissue tumors requiring precise diagnosis
Significant Benefits of FOXO1 Break Apart FISH Testing
Choosing the FOXO1 Break Apart FISH Diagnostic offers multiple advantages for patients and clinicians:
- Definitive Diagnosis: Provides conclusive evidence for alveolar rhabdomyosarcoma classification
- Treatment Guidance: Informs targeted therapy selection and treatment intensity decisions
- Prognostic Information: Helps predict disease behavior and potential treatment response
- Therapeutic Implications: Identifies patients who may benefit from specific treatment protocols
- Differential Diagnosis: Distinguishes alveolar rhabdomyosarcoma from other soft tissue tumors
- Clinical Trial Eligibility: May qualify patients for targeted therapy clinical trials
Understanding Your FOXO1 Break Apart FISH Test Results
Interpretation Guidelines
Your test results will be carefully interpreted by our expert molecular pathologists:
- Positive Result: Detection of FOXO1 gene rearrangement confirms alveolar rhabdomyosarcoma diagnosis
- Negative Result: Absence of FOXO1 rearrangement suggests alternative diagnoses should be considered
- Technical Considerations: Results may be affected by sample quality and tumor cellularity
- Clinical Correlation: Results should always be interpreted in conjunction with histological findings
- Follow-up Recommendations: Your healthcare provider will discuss appropriate next steps based on results
FOXO1 Break Apart FISH Test Pricing Information
| Test Name | Discount Price | Regular Price |
|---|---|---|
| FOXO1 Break Apart FISH Alveolar Rhabdomyosarcoma Diagnostic | $226 USD | $300 USD |
Nationwide Testing Availability
GGC DNA provides comprehensive FOXO1 Break Apart FISH testing services across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, San Francisco, Charlotte, Seattle, Denver, Washington DC, Boston, and many more. Our network of certified laboratories ensures consistent, high-quality testing standards nationwide.
Take Action for Accurate Diagnosis
Don’t leave your diagnosis to chance. The FOXO1 Break Apart FISH Alveolar Rhabdomyosarcoma Diagnostic provides the genetic clarity needed for optimal treatment decisions. Our experienced oncology genetics team is ready to assist you with this critical diagnostic testing.
Book your FOXO1 Break Apart FISH test today by calling our dedicated genetics specialists at +1(267) 388-9828 or schedule your appointment online. Take the first step toward precise diagnosis and personalized treatment planning with GGC DNA’s advanced molecular testing services.
