FLT4 Gene Lymphedema Hereditary Type 1A NGS Genetic DNA Test
Understanding Hereditary Lymphedema Type 1A
Hereditary lymphedema type 1A is a genetic condition characterized by chronic swelling in various body parts, primarily affecting the limbs. This condition results from mutations in the FLT4 gene, which plays a crucial role in the development and maintenance of the lymphatic system. The lymphatic system is essential for immune function and fluid balance throughout the body.
When the FLT4 gene contains mutations, it disrupts normal lymphatic vessel formation and function, leading to inadequate drainage of lymphatic fluid. This accumulation causes the characteristic swelling associated with lymphedema. Early detection through genetic testing can significantly improve management strategies and quality of life for affected individuals.
What Does the FLT4 Gene Test Detect?
Our advanced NGS (Next-Generation Sequencing) genetic test specifically targets the FLT4 gene to identify pathogenic variants associated with hereditary lymphedema type 1A. The test examines:
- Point mutations in the FLT4 gene coding regions
- Small insertions and deletions affecting gene function
- Copy number variations that may impact gene expression
- Regulatory region mutations affecting gene regulation
The FLT4 gene encodes vascular endothelial growth factor receptor 3 (VEGFR-3), a critical protein for lymphatic vessel development. Mutations in this gene impair the normal signaling pathways necessary for proper lymphatic system formation and maintenance.
Who Should Consider This Genetic Test?
Clinical Indications and Symptoms
This test is recommended for individuals experiencing:
- Persistent swelling in arms, legs, or other body parts
- Family history of lymphedema or similar swelling disorders
- Recurrent skin infections in swollen areas
- Skin thickening or hardening in affected limbs
- Early-onset swelling (typically appearing before age 35)
- Unexplained fluid accumulation despite normal cardiac and renal function
Additionally, individuals with a confirmed family history of FLT4 mutations should consider testing for early intervention and preventive care strategies.
Benefits of FLT4 Genetic Testing
Undergoing FLT4 genetic testing provides numerous advantages for patients and healthcare providers:
- Accurate Diagnosis: Confirms hereditary lymphedema type 1A, distinguishing it from other forms of lymphedema
- Personalized Treatment: Enables targeted management strategies based on genetic findings
- Family Planning: Provides crucial information for genetic counseling and family planning decisions
- Early Intervention: Allows for proactive management before severe complications develop
- Comprehensive Care: Facilitates multidisciplinary approach involving dermatologists, geneticists, and lymphedema specialists
- Peace of Mind: Reduces uncertainty and provides clear answers about genetic predisposition
Understanding Your Test Results
Possible Outcomes and Their Meanings
Your FLT4 genetic test results will fall into one of several categories:
- Positive Result: A pathogenic mutation was identified in the FLT4 gene, confirming hereditary lymphedema type 1A diagnosis. This result enables targeted treatment planning and family member testing.
- Negative Result: No pathogenic FLT4 mutations were detected. This may indicate that symptoms are due to other causes, though rare mutations or other genetic factors cannot be completely excluded.
- Variant of Uncertain Significance (VUS): A genetic change was found, but its clinical significance is currently unknown. Additional family testing may help clarify the variant’s importance.
- Carrier Status: Identifies individuals who carry one copy of a mutated gene but may not show symptoms, important for family planning considerations.
All results are accompanied by comprehensive genetic counseling to ensure proper understanding and appropriate next steps.
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | FLT4 Gene Lymphedema Hereditary Type 1A NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
| Specialty | Dermatology, Genetics |
Pre-Test Requirements and Genetic Counseling
Before undergoing the FLT4 genetic test, patients must complete:
- Comprehensive clinical history documentation
- Genetic counseling session with certified genetic counselor
- Development of detailed pedigree chart documenting family members affected by lymphedema symptoms
- Informed consent process explaining test implications and potential outcomes
Our genetic counseling services ensure patients fully understand the test’s purpose, potential results, and implications for themselves and family members.
Nationwide Testing Availability
We have testing facilities and collection centers across all major US cities, including:
- New York, NY
- Los Angeles, CA
- Chicago, IL
- Houston, TX
- Phoenix, AZ
- Philadelphia, PA
- San Antonio, TX
- San Diego, CA
- Dallas, TX
- San Jose, CA
Additional locations available throughout the United States to ensure convenient access for all patients.
Take Control of Your Genetic Health Today
Don’t let uncertainty about hereditary lymphedema affect your quality of life. Our FLT4 genetic test provides the answers you need for informed healthcare decisions. With our discounted price of $500 and comprehensive genetic counseling support, you can take the first step toward understanding your genetic predisposition and developing an effective management plan.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your FLT4 Gene Lymphedema Hereditary Type 1A NGS Genetic DNA Test.
Our team of genetic specialists is ready to guide you through the testing process and help you understand your results. Take advantage of our limited-time discount and secure your genetic health assessment today.
