FISH t(12;21) or LSI TEL/AML1 Test – Advanced Genetic Leukemia Detection
Understanding the FISH t(12;21) or LSI TEL/AML1 Test
The FISH t(12;21) or LSI TEL/AML1 Test represents a cutting-edge molecular diagnostic approach for detecting specific chromosomal abnormalities associated with pediatric acute lymphoblastic leukemia (ALL). This sophisticated test utilizes Fluorescence In Situ Hybridization (FISH) technology to identify the t(12;21) chromosomal translocation, which results in the formation of the TEL/AML1 fusion gene. This genetic alteration is particularly significant as it represents the most common chromosomal translocation found in childhood ALL, affecting approximately 25% of cases.
The clinical importance of this test cannot be overstated. By accurately identifying the presence of the TEL/AML1 fusion gene, healthcare providers can make more informed decisions regarding treatment protocols, prognosis assessment, and long-term management strategies. The test provides critical information that helps distinguish between different subtypes of leukemia, enabling personalized medicine approaches that can significantly improve patient outcomes and quality of life.
What the Test Measures and Detects
The FISH t(12;21) or LSI TEL/AML1 Test specifically targets and identifies:
- The t(12;21)(p13;q22) chromosomal translocation
- Formation of the TEL/AML1 fusion gene
- Presence of abnormal genetic material in bone marrow or blood cells
- Specific molecular markers associated with pediatric ALL
- Genetic abnormalities that influence treatment response
This test employs specialized DNA probes that bind to specific regions on chromosomes 12 and 21. When the translocation occurs, these probes detect the abnormal fusion pattern, providing visual confirmation of the genetic rearrangement under fluorescence microscopy. The high sensitivity and specificity of FISH technology make it an invaluable tool for detecting minimal residual disease and monitoring treatment response.
Who Should Consider This Test
This specialized genetic test is recommended for individuals presenting with:
- Children and adolescents with suspected or newly diagnosed acute lymphoblastic leukemia
- Patients exhibiting symptoms such as persistent fatigue, unexplained bruising, or recurrent infections
- Individuals with abnormal blood counts suggesting bone marrow dysfunction
- Patients requiring precise leukemia subtype classification for treatment planning
- Cases where conventional cytogenetic analysis requires additional molecular confirmation
- Patients being evaluated for minimal residual disease monitoring
Oncologists and hematologists typically recommend this test when standard diagnostic methods indicate potential ALL or when specific clinical presentations suggest the presence of the TEL/AML1 fusion gene. Early testing can provide crucial information that guides initial treatment decisions and long-term management strategies.
Benefits of Taking the FISH t(12;21) Test
Undergoing the FISH t(12;21) or LSI TEL/AML1 Test offers numerous advantages:
- Accurate Diagnosis: Provides definitive identification of the TEL/AML1 fusion gene, ensuring precise leukemia classification
- Treatment Guidance: Helps oncologists select the most appropriate chemotherapy regimens and treatment intensities
- Prognostic Information: Patients with TEL/AML1-positive ALL generally have better treatment outcomes and survival rates
- Minimal Residual Disease Monitoring: Enables sensitive detection of remaining leukemia cells after treatment
- Personalized Care: Facilitates tailored treatment approaches based on specific genetic abnormalities
- Family Planning: Provides valuable information for genetic counseling in certain familial cases
Understanding Your Test Results
Interpreting FISH t(12;21) test results requires professional medical expertise, but general guidance includes:
Positive Result
A positive result indicates the presence of the t(12;21) translocation and TEL/AML1 fusion gene. This typically confirms the diagnosis of TEL/AML1-positive acute lymphoblastic leukemia. Patients with this genetic profile often respond well to standard chemotherapy protocols and generally have favorable long-term outcomes. However, treatment decisions should always be made in consultation with your hematologist or oncologist.
Negative Result
A negative result means the t(12;21) translocation was not detected. This suggests that the patient’s leukemia may belong to a different genetic subtype, requiring alternative diagnostic approaches and potentially different treatment strategies. Additional genetic testing may be recommended to identify other chromosomal abnormalities.
Inconclusive Result
In rare cases, technical factors or sample quality issues may lead to inconclusive results. Your healthcare provider will discuss the need for repeat testing or alternative diagnostic methods.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $150 |
| Regular Price | $188 |
Turnaround Time: Sample accepted daily by 4 pm; Report delivered within 4 working days
Sample Requirements: 5 mL (3 mL minimum) whole blood OR 4 mL (2 mL minimum) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22°C. DO NOT FREEZE.
Important Note: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory for all test requests.
Nationwide Availability
GGC DNA maintains testing facilities and collection centers across major metropolitan areas throughout the United States. Our network includes locations in:
- New York City and surrounding areas
- Los Angeles and Southern California
- Chicago and the Midwest region
- Houston and Texas metropolitan areas
- Miami and Florida locations
- Philadelphia and Northeast centers
- Phoenix and Southwest facilities
- San Antonio and additional Texas sites
- San Diego and California coastal areas
- Dallas and North Texas regions
Our extensive network ensures that patients nationwide have access to this critical genetic testing service with consistent quality standards and reliable turnaround times.
Take Action Today
Don’t delay in obtaining the crucial genetic information needed for accurate leukemia diagnosis and treatment planning. The FISH t(12;21) or LSI TEL/AML1 Test provides essential insights that can significantly impact treatment decisions and patient outcomes.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your test appointment or to speak with our genetic counseling specialists. Our team is available to answer your questions, provide guidance on sample collection, and help coordinate testing through your healthcare provider.
Early and accurate genetic testing can make a substantial difference in leukemia management. Trust GGC DNA for reliable, precise, and timely genetic diagnostics that support better health outcomes for you and your family.
