FISH NTRK3 Gene Rearrangement Assay Test
Comprehensive Introduction to NTRK3 Gene Testing
The FISH NTRK3 Gene Rearrangement Assay represents a groundbreaking advancement in precision oncology, offering patients and healthcare providers critical insights into cancer genetics. This sophisticated diagnostic tool specifically targets the neurotrophic tyrosine receptor kinase 3 (NTRK3) gene, which plays a pivotal role in cellular growth, differentiation, and survival pathways. When NTRK3 undergoes rearrangement, it can lead to the formation of fusion proteins that drive uncontrolled cancer cell proliferation across multiple tumor types.
Understanding NTRK3 gene status has become increasingly important in modern cancer care, as it directly influences treatment decisions and therapeutic outcomes. The identification of NTRK fusions has revolutionized oncology practice, enabling clinicians to deploy highly effective targeted therapies that specifically inhibit abnormal TRK signaling pathways.
What the FISH NTRK3 Test Detects
This specialized assay utilizes Fluorescence In Situ Hybridization (FISH) technology to detect specific chromosomal rearrangements involving the NTRK3 gene located at chromosome 15q25.3. The test precisely identifies:
- Gene fusions involving NTRK3 with various partner genes
- Chromosomal translocations affecting the NTRK3 locus
- Structural rearrangements that create oncogenic fusion proteins
- Specific breakpoints within the NTRK3 gene region
The FISH methodology provides exceptional sensitivity and specificity, allowing for direct visualization of gene rearrangements at the single-cell level within tumor tissue samples.
Who Should Consider NTRK3 Testing
This genetic assay is particularly recommended for patients presenting with:
Specific Cancer Types
- Pediatric solid tumors with uncertain histology
- Secretory breast carcinomas
- Infantile fibrosarcomas
- Congenital mesoblastic nephromas
- Papillary thyroid cancers
- Various sarcomas and soft tissue tumors
Clinical Scenarios
- Patients with advanced or metastatic cancers seeking targeted therapy options
- Individuals with rare tumor types where NTRK fusions are known to occur
- Cases where conventional treatments have shown limited effectiveness
- Patients being considered for TRK inhibitor therapy
Significant Benefits of NTRK3 Gene Testing
Undergoing FISH NTRK3 testing provides multiple clinical advantages:
- Precision Treatment Guidance: Identifies patients who may respond exceptionally well to TRK inhibitor therapies
- Personalized Oncology: Enables tailored treatment strategies based on individual genetic profiles
- Improved Outcomes: Patients with NTRK fusions often experience remarkable responses to targeted therapies
- Comprehensive Molecular Profiling: Complements other genetic testing for complete tumor characterization
- Therapeutic Optimization: Helps avoid ineffective treatments and potential side effects
Understanding Your Test Results
Interpreting FISH NTRK3 results requires careful consideration by qualified oncology specialists:
Positive Result
A positive finding indicates the presence of NTRK3 gene rearrangement, suggesting eligibility for TRK inhibitor therapy. This result typically leads to discussions about targeted treatment options with potentially high response rates.
Negative Result
A negative result means no NTRK3 rearrangement was detected in the tested sample. While this excludes one specific targeted therapy option, it guides clinicians toward alternative treatment strategies and additional molecular testing.
Inconclusive Result
Occasionally, technical factors or sample quality may lead to inconclusive findings. In such cases, repeat testing or alternative methodologies may be recommended.
Test Pricing and Availability
| Test Description | Regular Price | Discount Price |
|---|---|---|
| FISH NTRK3 Gene Rearrangement Assay | $196 USD | $176 USD |
Nationwide Testing Accessibility
GGC DNA maintains comprehensive diagnostic facilities across major metropolitan areas throughout the United States, including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network ensures convenient access to advanced genetic testing regardless of your location.
Take Action for Precision Cancer Care
Don’t leave your cancer treatment to chance. The FISH NTRK3 Gene Rearrangement Assay provides critical genetic information that could significantly impact your therapeutic journey. Our experienced oncology genetics team is ready to assist you with comprehensive testing and expert interpretation.
Schedule your FISH NTRK3 testing today by calling our dedicated genetics hotline at +1(267) 388-9828 or visit your nearest GGC DNA facility. With sample collection daily until 6 PM and results available within 4 working days, we provide timely, accurate genetic insights to support your cancer treatment decisions.
Remember: Early genetic profiling can open doors to targeted therapies that may offer improved outcomes and quality of life. Trust GGC DNA for reliable, advanced molecular diagnostics in oncology genetics.