FISH NTRK2 Gene Rearrangement Assay Test
Comprehensive Introduction to NTRK2 Gene Testing
The FISH NTRK2 Gene Rearrangement Assay represents a breakthrough in precision oncology, offering targeted detection of genetic abnormalities that drive cancer progression. This advanced diagnostic tool utilizes fluorescence in situ hybridization (FISH) technology to identify specific rearrangements in the NTRK2 gene located on chromosome 9q21.3. These genetic alterations create fusion proteins that continuously activate cell growth pathways, leading to uncontrolled tumor development across multiple cancer types.
Understanding NTRK2 rearrangements is crucial because they occur in various malignancies regardless of tissue origin, making this test valuable for patients with diverse cancer diagnoses. The detection of these fusions opens the door to highly effective targeted therapies that specifically inhibit the abnormal proteins produced by rearranged genes.
What the Test Measures and Detects
The FISH NTRK2 Gene Rearrangement Assay specifically identifies:
- Chromosomal rearrangements involving the NTRK2 gene
- TRK fusion proteins that drive oncogenic signaling
- Genetic abnormalities that make tumors susceptible to targeted therapy
- Specific breakpoints in the 9q21.3 chromosomal region
This test employs dual-color break-apart FISH probes that flank the NTRK2 gene region. When a rearrangement occurs, the normally adjacent probes separate, indicating a genetic alteration that may respond to TRK inhibitor medications.
Who Should Consider This Test
Clinical Indications and Symptoms
This genetic assay is particularly important for patients with:
- Solid tumors lacking other driver mutations
- Pediatric cancers with unusual presentations
- Rare malignancies with limited treatment options
- Advanced cancers requiring targeted therapy options
- Tumors with histology suggesting NTRK fusion potential
- Patients seeking comprehensive genomic profiling
Specific Cancer Types Benefiting from Testing
- Infantile fibrosarcoma
- Secretory breast carcinoma
- Mammary analog secretory carcinoma
- Congenital mesoblastic nephroma
- Various sarcomas and brain tumors
Significant Benefits of NTRK2 Testing
Undergoing the FISH NTRK2 Gene Rearrangement Assay provides multiple advantages:
- Precision Treatment Selection: Identifies patients who may benefit from FDA-approved TRK inhibitors
- Improved Outcomes: Targeted therapies often show higher response rates with fewer side effects
- Comprehensive Cancer Profiling: Complements other genetic tests for complete molecular characterization
- Early Intervention: Enables timely initiation of appropriate targeted treatments
- Personalized Medicine: Tailors cancer therapy to individual genetic profiles
Understanding Your Test Results
Interpretation Guidelines
Your FISH NTRK2 test results will fall into one of these categories:
- Positive for Rearrangement: Indicates presence of NTRK2 gene fusion, making you a candidate for TRK inhibitor therapy
- Negative for Rearrangement: No NTRK2 fusion detected; alternative treatment strategies should be considered
- Inconclusive: May require additional testing or sample collection
It’s essential to discuss your results with your oncologist, who will interpret them in the context of your specific cancer type, stage, and overall health status. Positive results typically indicate eligibility for targeted therapies that can significantly improve treatment response.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $176 |
| Regular Price | $196 |
Test Specifications
- Turnaround Time: Sample accepted daily by 6 PM; Results in 4 working days
- Sample Requirements: Formalin-fixed paraffin-embedded tissue block or three 4-micron sections on Poly-L-Lysine coated slides
- Shipping: Room temperature transport
- Mandatory Documentation: Completed Genomics Clinical Information Requisition Form (Form 20)
Nationwide Testing Availability
We provide comprehensive genetic testing services across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network ensures accessible, high-quality genetic testing regardless of your location.
Take Action for Your Health
Don’t leave your cancer treatment to chance. The FISH NTRK2 Gene Rearrangement Assay could be the key to unlocking targeted therapy options that may significantly improve your treatment outcomes. Our experienced genetic counselors and oncology specialists are ready to guide you through the testing process and help interpret your results.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your FISH NTRK2 Gene Rearrangement Assay and take the first step toward personalized cancer care.
Early detection of NTRK2 rearrangements can transform your cancer treatment journey, providing access to cutting-edge targeted therapies that offer new hope and improved quality of life. Book your test now and empower yourself with the genetic information needed to fight cancer effectively.
