FISH NTRK1 Gene Rearrangement Assay Test
Comprehensive Introduction to NTRK1 Gene Testing
The FISH NTRK1 Gene Rearrangement Assay represents a cutting-edge advancement in molecular oncology diagnostics. This sophisticated test utilizes Fluorescence In Situ Hybridization (FISH) technology to detect specific genetic rearrangements in the NTRK1 gene, which encodes the tropomyosin receptor kinase A (TRKA) protein. These rearrangements create fusion proteins that drive uncontrolled cell growth and proliferation in various cancer types.
The clinical importance of NTRK1 testing cannot be overstated, as it directly impacts treatment decisions and patient outcomes. NTRK gene fusions are considered oncogenic drivers across multiple tumor types, and their identification opens the door to highly effective targeted therapies that specifically inhibit the abnormal TRK proteins produced by these genetic alterations.
What the Test Measures and Detects
The FISH NTRK1 Gene Rearrangement Assay specifically identifies:
- Chromosomal rearrangements involving the NTRK1 gene located at 1q21.3
- Gene fusion events that create novel oncogenic proteins
- Specific breakpoints that result in constitutive TRK kinase activation
- Genetic alterations that make tumors susceptible to TRK inhibitor therapies
This test employs dual-color break-apart FISH probes that flank the NTRK1 gene region. When a rearrangement occurs, the normally adjacent probes separate, indicating a genetic alteration that may create a fusion oncogene. The assay provides both qualitative and semi-quantitative data about NTRK1 status in tumor cells.
Who Should Consider This Test
Clinical Indications and Patient Populations
This test is particularly valuable for patients with:
- Advanced or metastatic solid tumors without other known driver mutations
- Rare cancer types where NTRK fusions are more common
- Pediatric cancers, especially infantile fibrosarcoma and congenital mesoblastic nephroma
- Salivary gland tumors, particularly secretory carcinoma
- Thyroid cancer, especially papillary thyroid carcinoma
- Soft tissue sarcomas and gastrointestinal stromal tumors
- Patients who have exhausted standard treatment options
Symptoms and Clinical Scenarios
Consider NTRK1 testing when patients present with:
- Treatment-resistant cancers progressing despite conventional therapies
- Metastatic disease with unknown primary origin
- Rare tumor histologies associated with NTRK fusions
- Family history suggestive of genetic cancer predisposition
- Younger patients with aggressive cancer presentations
Benefits of Taking the NTRK1 Test
Undergoing NTRK1 gene rearrangement testing offers multiple significant advantages:
Personalized Treatment Planning
Identification of NTRK1 rearrangements enables precision medicine approaches, allowing oncologists to select targeted therapies specifically designed to inhibit TRK fusion proteins. This personalized approach often leads to improved treatment responses and reduced side effects compared to conventional chemotherapy.
Expanded Therapeutic Options
Positive test results open access to FDA-approved TRK inhibitors such as larotrectinib and entrectinib, which have demonstrated remarkable efficacy in NTRK fusion-positive cancers across multiple tumor types.
Improved Prognostic Information
Understanding the molecular drivers of a patient’s cancer provides valuable prognostic information and helps guide expectations about treatment response and disease course.
Clinical Trial Eligibility
NTRK1 testing results may qualify patients for clinical trials investigating novel TRK-targeted therapies and combination treatments.
Understanding Your Test Results
Interpretation Guidelines
Your FISH NTRK1 Gene Rearrangement Assay results will fall into one of several categories:
Positive Result
A positive result indicates the presence of NTRK1 gene rearrangement, suggesting the tumor may respond to TRK inhibitor therapy. This finding should be discussed with your oncology team to determine the most appropriate targeted treatment approach.
Negative Result
A negative result means no NTRK1 rearrangement was detected in the tested sample. This suggests that TRK inhibitor therapy may not be effective, and alternative treatment strategies should be considered.
Inconclusive Result
Occasionally, technical factors or sample quality may lead to inconclusive results. In such cases, repeat testing or alternative testing methods may be recommended.
Clinical Correlation
It’s essential to interpret NTRK1 test results in the context of your complete clinical picture, including tumor type, stage, previous treatments, and overall health status. Your oncologist will integrate this genetic information with other diagnostic findings to develop a comprehensive treatment plan.
Test Pricing and Availability
| Price Type | Amount (USD) | Details |
|---|---|---|
| Discount Price | $176 | Special promotional rate |
| Regular Price | $196 | Standard pricing |
Service Details
- Turnaround Time: Sample accepted daily by 6 PM; Reports delivered in 4 working days
- Sample Type: Formalin-fixed paraffin-embedded tissue block or three 4-micron sections on Poly L Lysine coated slides
- Shipping: Room temperature shipment required
- Required Documentation: Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory
Nationwide Availability
We have diagnostic centers conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures accessible, high-quality genetic testing services for patients nationwide.
Take Action Today
Don’t leave your cancer treatment to chance. The FISH NTRK1 Gene Rearrangement Assay provides critical information that could transform your treatment approach and potentially improve your outcomes. Our experienced team is ready to guide you through the testing process and ensure you receive the comprehensive genetic information needed for informed decision-making.
Ready to schedule your test? Contact us today at +1(267) 388-9828 or book your appointment online. Our genetic counseling team is available to answer your questions and help you understand how NTRK1 testing could benefit your specific situation.
Take the first step toward personalized cancer care with the FISH NTRK1 Gene Rearrangement Assay – your pathway to targeted treatment options and potentially improved cancer outcomes.
